<abstract xmlns="http://www.w3.org/1999/xhtml">The JR blood group system (ISBT 032) consists of one antigen, Jra, which is of high prevalence in all populations. The rare Jr(a–) phenotype has been found mostly in Japanese and other Asian populations, but also in people of northern European ancestry, in Bedouin Arabs, and in one Mexican. Anti-Jrahas caused transfusion reactions and is involved in hemolytic disease of the fetus and newborn. The Jraantigen is located on ABCG2 transporter, a multipass membrane glycoprotein (also known as the breast cancer resistance protein, BCRP), which is encoded by the <italic>ABCG2</italic>gene on chromosome 4q22.1. The Jr(a–) phenotype mostly results from recessive inheritance of <italic>ABCG2</italic>null alleles caused by frameshift or nonsense changes. <italic><bold>Immunohematology</bold></italic><bold>2013;29:63–68.</bold></abstract>

The JR blood group system (ISBT 032) consists of one antigen, Jra, which is of high prevalence in all populations. The rare Jr(a–) phenotype has been found mostly in Japanese and other Asian populations, but also in people of northern European ancestry, in Bedouin Arabs, and in one Mexican. Anti-Jrahas caused transfusion reactions and is involved in hemolytic disease of the fetus and newborn. The Jraantigen is located on ABCG2 transporter, a multipass membrane glycoprotein (also known as the breast cancer resistance protein, BCRP), which is encoded by the ABCG2gene on chromosome 4q22.1. The Jr(a–) phenotype mostly results from recessive inheritance of ABCG2null alleles caused by frameshift or nonsense changes. Immunohematology2013;29:63–68.

A review of the JR blood group system

Immunohematology

{"article-title":"A review of the JR blood group system"}

The JR blood group system (ISBT 032) consists of one antigen, Jra, which is of high prevalence in all populations. The rare Jr(a–) phenotype has been found...

A review of the JR blood group system

Article Category: Review

Pubblicato online: 01 dic 2019

Pagine: 63 - 68

DOI: https://doi.org/10.21307/immunohematology-2019-126

© 2013 L. Castilho, et al., published by Sciendo