<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Platelets express a variety of polymorphic glycoproteins (GPs), such as GPIIb/IIIa, GPIb/IX, GPIa/IIa, GPIV, and class I human leukocyte antigen. In the platelet transfusion setting, alloimmunization involves the production of antibodies against these glycoproteins. Patients transfused with multiple units of platelet concentrates for longer periods are the main individuals with platelet alloimmunization. This study was performed to detect the development of platelet antibodies in patients who are transfused with multiple units of leukodepleted platelet concentrates, such as those with hemato-oncologic diseases and bone marrow failure syndromes. The method used was solid-phase modified antigen capture enzyme-linked immunosorbent assay. Platelet refractoriness was assessed by measuring the corrected count increment at 1 and 24 hours after transfusion. <italic><bold>Immunohematology</bold></italic><bold>2014;30:123–125.</bold></p></abstract>

Platelets express a variety of polymorphic glycoproteins (GPs), such as GPIIb/IIIa, GPIb/IX, GPIa/IIa, GPIV, and class I human leukocyte antigen. In the platelet transfusion setting, alloimmunization involves the production of antibodies against these glycoproteins. Patients transfused with multiple units of platelet concentrates for longer periods are the main individuals with platelet alloimmunization. This study was performed to detect the development of platelet antibodies in patients who are transfused with multiple units of leukodepleted platelet concentrates, such as those with hemato-oncologic diseases and bone marrow failure syndromes. The method used was solid-phase modified antigen capture enzyme-linked immunosorbent assay. Platelet refractoriness was assessed by measuring the corrected count increment at 1 and 24 hours after transfusion. Immunohematology2014;30:123–125.

Detection and identification of platelet-associated alloantibodies by a solid-phase modified antigen capture enzyme-linked immunosorbent assay method and its correlation to platelet refractoriness in multiplatelet concentrate–transfused patients

Immunohematology

Platelets express a variety of polymorphic glycoproteins (GPs), such as GPIIb/IIIa, GPIb/IX, GPIa/IIa, GPIV, and class I human leukocyte antigen. In the...

Detection and identification of platelet-associated alloantibodies by a solid-phase modified antigen capture enzyme-linked immunosorbent assay method and its correlation to platelet refractoriness in multiplatelet concentrate–transfused patients

Article Category: Original Report

Pubblicato online: 01 dic 2019

Pagine: 123 - 125

DOI: https://doi.org/10.21307/immunohematology-2019-107

Parole chiave
HLA, platelet glycoproteins, platelet alloimmunization, MACE

© 2014 N. Jain et al., published by Sciendo

Detection and identification of platelet-associated alloantibodies by a solid-phase modified antigen capture enzyme-linked immunosorbent assay method and its correlation to platelet refractoriness in multiplatelet concentrate–transfused patients

Article Category: Original Report

Pubblicato online: 01 dic 2019

Pagine: 123 - 125

DOI: https://doi.org/10.21307/immunohematology-2019-107

Parole chiaveHLA, platelet glycoproteins, platelet alloimmunization, MACE

© 2014 N. Jain et al., published by Sciendo

Parole chiave
HLA, platelet glycoproteins, platelet alloimmunization, MACE