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This article reviews information regarding the clinical significance of antibodies to antigens in the blood group collections, the 700 series of low-incidence antigens, and the 901 series of high-incidence antigens. Antibodies to many of the antigens in these groups are rarely encountered, meaning that available information is limited. For a few, the clinical significance— the potential to cause reduced survival of transfused antigen-positive red blood cells, a hemolytic transfusion reaction (e.g., anti-AnWj, anti-Emm), or hemolytic disease of the fetus and newborn (e.g., anti-Kg, anti-HJK)—has been documented. Many other specificities have so far been benign (e.g., anti-Csa, anti-M1). <italic><bold>Immunohematology</bold></italic> <bold>2018;34:39–45.</bold>
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This article reviews information regarding the clinical significance of antibodies to antigens in the blood group collections, the 700 series of low-incidence antigens, and the 901 series of high-incidence antigens. Antibodies to many of the antigens in these groups are rarely encountered, meaning that available information is limited. For a few, the clinical significance— the potential to cause reduced survival of transfused antigen-positive red blood cells, a hemolytic transfusion reaction (e.g., anti-AnWj, anti-Emm), or hemolytic disease of the fetus and newborn (e.g., anti-Kg, anti-HJK)—has been documented. Many other specificities have so far been benign (e.g., anti-Csa, anti-M1). Immunohematology 2018;34:39–45.

Clinical significance of antibodies to antigens in the International Society of Blood Transfusion collections, 700 series of low-incidence antigens, and 901 series of high-incidence antigens

Immunohematology

This article reviews information regarding the clinical significance of antibodies to antigens in the blood group collections, the 700 series of low-incidence...

Clinical significance of antibodies to antigens in the International Society of Blood Transfusion collections, 700 series of low-incidence antigens, and 901 series of high-incidence antigens

Article Category: Review

Pubblicato online: 16 ott 2019

Pagine: 39 - 45

DOI: https://doi.org/10.21307/immunohematology-2018-007

© 2018 C. Lomas-Francis, published by Sciendo