Effects of strontium ranelate on sutural bone formation: a histological and immunohistochemical study
Pubblicato online: 15 ago 2021
Pagine: 139 - 147
Ricevuto: 01 mag 2016
Accettato: 01 lug 2016
DOI: https://doi.org/10.21307/aoj-2020-121
© 2016 Orhan H. Karataş et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Aim
Rapid maxillary expansion is performed to correct a skeletal transverse deficiency of the maxilla, which is a frequently- encountered orthodontic anomaly. Strontium ranelate (SrR) is a novel agent that has a dual action, involving anti-resorptive and bone-forming effects. The aim of this study was to evaluate the effects of systemically applied SrR on osteoblastic bone formation after maxillary expansion on the mid-palatal suture of rats using histological and immunohistochemical tests.
Materials and methods
A total of 24 Wistar rats were randomly divided into two equal groups. In all animals, five-day inter- premaxillary expansion was applied and maintained for a seven-day retention period, during which 625mg/kg/day SrR diluted with saline solution was administered orally to the experimental group. The rats were sacrificed and the tissues prepared for histological and immunohistochemical examinations after the retention period.
Results
Osteoblastic activity and the width of the blood vessels in the suture area were significantly increased in the SrR group compared with the control group (
Conclusion
It may be concluded that SrR contributed to stimulatory osteogenesis in the expansion region. Therefore, a retention period may be shortened and relapse possibly reduced, following the application of SrR after the expansion.