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Haemostatic action of a topical foam-based patch (VELSEAL-T) in haemophiliac patients with external bleeding

Anupam Dutta
Anupam Dutta
, 
Taniya Sarkar Dutta
Taniya Sarkar Dutta
, 
Anup Kumar Das
Anup Kumar Das
 e 
Pranoy Dey
Pranoy Dey
   | 17 giu 2020
The Journal of Haemophilia Practice's Cover Image
INFORMAZIONI SU QUESTO ARTICOLO
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Article Category: Clinical Research
Pubblicato online: 17 giu 2020
Pagine: 78 - 84
DOI: https://doi.org/10.17225/jhp00160
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© 2020 Anupam Dutta et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The use of a haemostatic patch to treat external injuries in people with haemophilia presenting at a hospital in Northeast India suggests that it may be a beneficial first aid dressing, particularly in low resource settings where access to factor concentrates is limited.© Shutterstock
The use of a haemostatic patch to treat external injuries in people with haemophilia presenting at a hospital in Northeast India suggests that it may be a beneficial first aid dressing, particularly in low resource settings where access to factor concentrates is limited.© Shutterstock

Figure 1

Mean time (minutes) to achieve haemostasis in different wound types
Mean time (minutes) to achieve haemostasis in different wound types

Figure 2

Electron microscope image of VELSEAL-T showing the porous spaces within the foam (reproduced with permission of Datt Mediproducts Pvt. Ltd)
Electron microscope image of VELSEAL-T showing the porous spaces within the foam (reproduced with permission of Datt Mediproducts Pvt. Ltd)

Bleeding in each wound type (total number of wounds = 59)

ABRASION(N=9)CUT OR LACERATION(N=24)TOOTH OR GUM BLEEDING(N=21)PUNCTURE(N=5)P-VALUE
Age of patient*18.78 (±6.6)21.67 (±9.7)8.0 (±5.8)23.8 (±18.2)<0.001
Size of injury(cm)#2.2 (±1.2)2.0 (±1.0)1.0 (±0.2)1.0 (±0.0)0.003
Time to achieve haemostasis (minutes)#7.3 (±4.4)8.5 (±2.9)12.7 (±5.6)9.0 (±3.1)0.011
Ease of handling (1 to 5)#1 (±0)1.1 (±0.3)2.3 (±1.2)1.6 (±0.5)<0.001
Ease of application to the site (1 to 5)#1.6 (±0.9)1.4 (v0.6)3.0 (±1.6)1.6 (±0.9)0.001
Conformance to tissue surface (1 to 5)#1.0 (±0)1.3 (v0.5)2.4 (±1.4)1.6 (±0.9)0.003
Overall performance of the device (1 to 5)#1.2 (±0.4)1.3 (±0.4)2.3 (±1.1)1.4 (±0.5)<0.001

Demographics of the study group (n=48)

NUMBER (N)PERCENTAGE (%)
Haemophilia A4287.5%
  Mild (factor level 5–50%)510.4%
  Moderate (factor level 1–5%)714.6%
  Severe (factor level <1%)3062.5%
Haemophilia B510.4%
  Mild (factor level 5–50%)0–
  Moderate (factor level 1–5%)12.1%
  Severe (factor level <1%)48.3%
Other bleeding disorders (factor X deficiency)12.1%
Children (under 18 years)2858.3%
Adults (18 years and above)2041.7%
Total number of external injuries59
PwH presenting with a single episode of external injury3879.2%
PwH presenting with two episodes of external injury918.7%
PwH presenting with three episodes of external injury12.1%
eISSN:
2055-3390
Lingua:
Inglese
Frequenza di pubblicazione:
Volume Open
Argomenti della rivista:
Medicine, Basic Medical Science, other, Clinical Medicine, Pharmacy, Pharmacology
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