<abstract xmlns="http://www.w3.org/1999/xhtml"><p> We report a male infant diagnosed at the age of 10 months with hyper-IgM syndrome (HIGM) in context of severe infections caused by Streptococcus pneumoniae, Staphylococcus aureus and Candida albicans. In patient’s outcome, in spite of immunoglobulin therapy, he continues presenting bilateral suppurative otitis media due to both Candida and penicillin-resistant pneumococcus and forearm abscess caused by Staphylococcus aureus. The infant developed bilateral cataracts, chronic hepatitis and comminuted fracture secondary to bone demineralization. The patient didn’t develop opportunistic infections as compare to CD40 Ligand deficiency patients. In contrast with the majority of HIGM cases, the infant necessity for immunoglobulin substitution was very limited. As a particularity of immunological phenotype, the patient IgM value progressively increased at a high level.</p></abstract>

We report a male infant diagnosed at the age of 10 months with hyper-IgM syndrome (HIGM) in context of severe infections caused by Streptococcus pneumoniae, Staphylococcus aureus and Candida albicans. In patient’s outcome, in spite of immunoglobulin therapy, he continues presenting bilateral suppurative otitis media due to both Candida and penicillin-resistant pneumococcus and forearm abscess caused by Staphylococcus aureus. The infant developed bilateral cataracts, chronic hepatitis and comminuted fracture secondary to bone demineralization. The patient didn’t develop opportunistic infections as compare to CD40 Ligand deficiency patients. In contrast with the majority of HIGM cases, the infant necessity for immunoglobulin substitution was very limited. As a particularity of immunological phenotype, the patient IgM value progressively increased at a high level.

Peculiar hyper-IgM syndrome. Case report / Sindrom hiper-IgM atipic. Prezentare de caz

Lucian Blaga University of Sibiu, Romania

Department of Infectious and Pediatric Immunology, Medical and Health Science Center, Debrecen; University of Debrecen, Hungary

Study center for Immunodeficiencies, Necker-Enfants Malades Hospital, Paris, France; Paris Descartes Sorbonne Paris Cité University, Imagine Institute, Paris, France

Revista Romana de Medicina de Laborator

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

We report a male infant diagnosed at the age of 10 months with hyper-IgM syndrome (HIGM) in context of severe infections caused by Streptococcus pneumoniae,...

Peculiar hyper-IgM syndrome. Case report / Sindrom hiper-IgM atipic. Prezentare de caz

Pubblicato online: 30 set 2015

Pagine: 341 - 345

Ricevuto: 26 lug 2015

Accettato: 26 lug 2015

DOI: https://doi.org/10.1515/rrlm-2015-0027

Parole chiave
hyper-IgM syndrome, severe infections, recurrent infections, bone disease

© by Sorin Ioan Iurian

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Peculiar hyper-IgM syndrome. Case report / Sindrom hiper-IgM atipic. Prezentare de caz

Pubblicato online: 30 set 2015

Pagine: 341 - 345

Ricevuto: 26 lug 2015

Accettato: 26 lug 2015

DOI: https://doi.org/10.1515/rrlm-2015-0027

Parole chiavehyper-IgM syndrome, severe infections, recurrent infections, bone disease

© by Sorin Ioan Iurian

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Parole chiave
hyper-IgM syndrome, severe infections, recurrent infections, bone disease