1. bookVolume 23 (2015): Edizione 3 (August 2015)
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eISSN
2284-5623
Prima pubblicazione
08 Aug 2013
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4 volte all'anno
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Inglese
access type Accesso libero

Usefulness of Presepsin (sCD14-ST) in diagnosis of Infective Endocarditis - preliminary results of an observational study / Utilitatea presepsinului (sCD14-ST) în Endocardita Infecțioasă –rezultate preliminare ale unui studiu observațional

Pubblicato online: 30 Sep 2015
Volume & Edizione: Volume 23 (2015) - Edizione 3 (August 2015)
Pagine: 303 - 311
Ricevuto: 12 Mar 2015
Accettato: 26 Jun 2015
Dettagli della rivista
License
Formato
Rivista
eISSN
2284-5623
Prima pubblicazione
08 Aug 2013
Frequenza di pubblicazione
4 volte all'anno
Lingue
Inglese
Abstract

Background: Soluble CD14 subtype (sCD14-ST), also named presepsin, has been proposed as a novel biomarker for the diagnosis of sepsis. We hypothesized that presepsin value might be helpful in the diagnosis of infective endocarditis (IE).

Material and methods: In this prospective study a total of 29 patients with clinical suspicion of IE were enrolled. The plasma presepsin samples were collected at the admittance in the same time with blood cultures, CRP (C-reactive protein) and routine blood tests. Data about the antibiotic treatment prior to admittance were recorded. The diagnosis of IE was made using the Duke modified criteria. Receiver operating characteristic (ROC) curves analysis and binary logistic regression were performed using SPSS software, version 18. A p value less than 0.05 is considered statistically significant.

Results: Patients were divided in two subgroups: 14 patients with definite IE and 8 with IE - rejected according to the modified Duke criteria. 7 patients with final diagnosis of sepsis were excluded. Presepsin levels in patient with definite IE were significantly higher than in those with rejected IE (p<0.03). The area under the receiver operating characteristic curve (AUC) was 0.781 (95 % confidence interval (CI) 0.590 - 0.973). The threshold value of presepsin in predicting IE was determined to be 345 pg/ml, of which the clinical sensitivity and specificity were 64% and respectively, 88%. The AUC for CRP was 0.656 (95% CI 0.37-0.88).

Conclusion: Presepsin might be a useful additional diagnostic marker in patients with suspected IE. These preliminary results needs confirmation by future studies.

Keywords

Cuvinte cheie

1. Prendergast B. The changing face of infective endocarditis. Heart. 2006 Jul;92(7):879-85. DOI: 10.1136/ hrt.2005.06725610.1136/hrt.2005.067256186069816216860Search in Google Scholar

2. Li SJ, Sexton DJ, Mick N, Nettles R, Fowler VG, Ryan T, et al. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis. 2000 Apr;30(4):633-38. DOI: 10.1086/31375310.1086/31375310770721Search in Google Scholar

3. Lamas CC, Eykyn SJ. Blood culture negative endocarditis : analysis of 63 cases presenting over 25 years. Heart. 2003 Mar;89(3):258-62. DOI: 10.1136/ heart.89.3.25810.1136/heart.89.3.258176757912591823Search in Google Scholar

4. Heiro M, Helenius H, Sundell J, Koskinen P, Engblom E, Nikoskelainen J, et al. Utility of serum C-reactive protein in assessing the outcome of infective endocarditis. Eur Heart J. 2005 Sep;26(18):1873-81. DOI: 10.1093/eurheartj/ehi27710.1093/eurheartj/ehi27715855194Search in Google Scholar

5. Gouriet F, Bothelo-Nevers E, Coulibaly B, Raoult D. Evaluation of sedimentation rate, rheumatoid factor, C-reactive protein and tumor necrosis factor for the diagnosis of infective endocarditis. Clin Vaccine Immunol. 2006 Feb;13(2):301. DOI: 10.1128/ CVI.13.2.301.200610.1128/CVI.13.2.301.2006139193816467342Search in Google Scholar

6. Simon L, Gauvin F, Amre DV, Saint-Louis P, Lacroix J. Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin Infect Dis. 2004 Jul 15;39(2):206-17. DOI: 10.1086/42199710.1086/42199715307030Search in Google Scholar

7. Yu CW, Juan LI, Hsu SC, Chen CK, Wu CW, Lee CC, et al. Role of the procalcitonin in the diagnosis of infective endocarditis: a meta-analysis. Am J Emerg Med. 2013 Jun;31(6):935-41. DOI: 10.1016/j.ajem.2013.03.00810.1016/j.ajem.2013.03.00823601504Search in Google Scholar

8. Shozushima T, Takahashi G, Matsumoto N, Kojika M, Okamura Y, Endo S. Usefulness of presepsin (sCD14- ST) measurements as a marker for the diagnosis and severity of sepsis that satisfied diagnostic criteria of systemic inflammatory response syndrome. J Infect Chemoter. 2011 Dec;17(6):764-69. DOI: 10.1007/s10156-011-0254-x10.1007/s10156-011-0254-x21560033Search in Google Scholar

9. Mallet-Coste T, Chenevier-Gobeaux C, Fissore-Magdelein C, Magdelein X, Brod F, Claessens YE. La présepsine (sCD14-ST), nouveau biomarquer de la réponse anti-infectieuse. Ann Fr Med Urgence. 2013 Sept;3(5):305-9. DOI: 10.1007/s13341-013-0347-510.1007/s13341-013-0347-5Search in Google Scholar

10. Okamura Y, Yokoi H. Development of a point-of-care assay system for measurement of presepsin (sCD14- ST). Clin Chim Acta. 2011 Nov;412(23-24):2157-61. DOI: 10.1016/j.cca.2011.07.02410.1016/j.cca.2011.07.02421839732Search in Google Scholar

11. Yaeghashi Y, Shirakawa K, Sato N, Suzuki Y, Kojika M, Imai S, et al. Evaluation of a newly identified soluble CD14 subtype as a marker for sepsis. J Infect Chemoter. 2005;11(5):234-38. DOI: 10.1007/s10156-005-0400-410.1007/s10156-005-0400-416258819Search in Google Scholar

12. Romualdo LG, Torrella PE, González MV, Sánchez RJ, Hodalgo AH, Freire AO, et al. Diagnostic accuracy of presepsin (soluble CD14 subtype) for prediction of bacteremia in patients with systemic inflammatory response syndrome in the Emergency Departament. Clin Biochem. 2014 May;47(7):505-8. DOI: 10.1016/j.clinbiochem.2014.02.01110.1016/j.clinbiochem.2014.02.01124560955Search in Google Scholar

13. Endo S, Suzuki Y, Takahashi G, Shozushima T, Ishikura H, Murai A, et al. Usefulness of presepsin in the diagnosis of sepsis in a multicenter prospective study. J Infect Chemoter. 2012 Dec;18(6):891-97. DOI: 10.1007/ s10156-012-0435-210.1007/s10156-012-0435-222692596Search in Google Scholar

14. Werdan K, Dietz S, Löffler B, Niemann S, Bushnaq H, Silber RE, et al. Mechanisms of infective endocarditis: pathogen-host interaction and risk states. Nat Rev Cardiol. 2014;11(1):35-50. DOI: 10.1038/nrcardio.2013.17410.1038/nrcardio.2013.17424247105Search in Google Scholar

15. Christiansen JG, Jensen HE, Jensen LK, Koch J, Aalbaek B, Nielsen OL, et al. Systemic inflammatory response and local cytokine expression in porcine models of endocarditis. Acta Pathol Microbiol Immunol Scand. 2014 Apr;122(4):292-300. DOI: 10.1111/apm.1214510.1111/apm.1214523879680Search in Google Scholar

16. Habib G, Hoen B, Thornos P, Thuny F, Prendergast, Vilacosta I, et al. Guidelines of the prevention, diagnosis and treatment of infective endocarditis (new version 2009). The task force on the prevention, diagnosis and treatement of infective endocarditis of the European Society of Cardiology. Eur Heart J. 2009;30(19):2369-2413. DOI: 10.1093/eurheartj/ehp28510.1093/eurheartj/ehp28519713420Search in Google Scholar

17. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach O, Opal SM, et al. Surviving Sepsis Campaign Guidelines Committee including the Pediatric subgroup. Surviving Sepsis Campaign: International guidelines for the management of severe sepsis and septic shock:2012. Crit Care Med. 2013 Feb;41(2):580-637. DOI: 10.1097/CCM.0b013e31827e83af10.1097/CCM.0b013e31827e83af23353941Search in Google Scholar

18. Giavarina D, Carta M. Determination of reference interval for presepsin, an early marker for sepsis. Biochem Med. 2015;25(1):64-68. DOI: 10.11613/BM.2015.00710.11613/BM.2015.007440131025672468Search in Google Scholar

19. Ulla M, Pizzolato E, Lucchiari M, Loiacano M, Soardo F, Forno D, et al. Diagnostic and prognostic value of presepsin in the management of sepsis in the emergency department: a multicenter prospective study. Crit Care. 2013 Jul 20;17(4):R168. DOI: 10.1186/cc1284710.1186/cc12847405676223899120Search in Google Scholar

20. Chenevier-Gobeaux C, Trabattoni E, Roelens M, Borderie D, Claessens YE. Presepsin (sCD14-ST) in emergency department: the need for adapted threshold values? Clin Chim Acta. 2014 Jan 1;427:34-36. DOI: 10.1016/j.cca.2013.09.01910.1016/j.cca.2013.09.01924076253Search in Google Scholar

21. Behnes M, Bertsch T, Lepiorz D, Lang S, Trinkmann F, Brueckmann M, et al. Diagnostic and prognostic utility of soluble CD14 subtype (presepsin) for severe sepsis and septic shock during the first week of intensive care treatment. Crit Care. 2014;18(5):507. DOI: 10.1186/ s13054-014-0507-z10.1186/s13054-014-0507-z417428325190134Search in Google Scholar

22. Liu B, Yin Q, Chen YX, Zhao YZ, Li CS. Role of Presepsin (sCD14-ST) and the CURB65 scoring system in predicting severity and outcome of community- acquired pneumonia in an emergency department. Resp Med. 2014 Aug;108(8):1204-13. DOI: 10.1016/j. rmed.2014.05.005Search in Google Scholar

23. Zou Q, Wen W, Zhang X. Presepsin as a novel sepsis biomarker. World J Emerg Med. 2014;5(1):16-19. DOI: 10.5847/wjem.j.issn.1920-8642.2014.01.00210.5847/wjem.j.issn.1920-8642.2014.01.002412985725215141Search in Google Scholar

24. Murdoch DR, Corey GR, Hoen B, Miro J, Fowler VG, Bayer AS, et al. Clinical presentation, etiology and outcome of infective endocarditis in the 21st Century. Arch Intern Med. 2009 Mar 9; 169(5):463-473. DOI: 10.1001/archinternmed.2008.60310.1001/archinternmed.2008.603362565119273776Search in Google Scholar

25. Tariq M, Alam M, Munir G, Khan MA, Smego RA Jr. Infective endocarditis: a five - year experience at a tertiary care hospital in Pakistan. Int J Infect Dis. 2004 May;8(3):163-70. DOI: 10.1016/j.ijid.2004.02.00110.1016/j.ijid.2004.02.00115109591Search in Google Scholar

26. Kapla JM, Wrong HR. Biomarker discovery and the development in pediatric critical care medicine. Pediatr Crit Care Med. 2011;12(2):165-73. DOI: 10.1097/PCC.0b013e3181e28876 10.1097/PCC.0b013e3181e28876292446220473243Search in Google Scholar

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