SER (20% survival) / 2 Gy | ||
---|---|---|
Cell line | LN18 | LN229 |
50 µM TMZ | 1.11 | 2.15 |
1mM Metformin | 0.67 | 0.74 |
20 mM Metformin | 3.13 | 0.61 |
50 µM TMZ + 20mM Metformin | 2.57 | 2.69 |
Ln18 24h | 72h | G1 (%) ± sth.dev. | S (%) ± sth.dev. | G2/M (%) ± sth.dev. |
---|---|---|---|---|
Ctrl | 74.5 ± 8 | 5.6 ± 0 | 19.9 ± 1 | |
50µM TMZ | 66.0 ± 8 | 9.5 ± 1 | 24.6 ± 3 | |
1mM Metformin | 71.0 ± 5 | 6.3 ± 1 | 22.7 ± 0 | |
20mM Metformin | 46.9 ± 3 | 9.3 ± 2 | ||
50µM TMZ + 1mM Metformin | 64.5 ± 0 | 8.6 ± 4 | 26.9 ± 4 | |
50µM TMZ + 20mM Metformin | 41.2 ± 0 | 19.4 ± 7 | 39.4 ± 2 | |
2Gy | 71.7 ± 1 | 7.5 ± 1 | 20.8 ± 4 | |
6Gy | 56.2 ± 5 | 8.0 ± 1 | 35.7 ± 1 | |
2Gy + 50µM TMZ | 62.0 ± 5 | 6.6 ± 5 | 31.4 ± 4 | |
2Gy + 1mM Metformin | 68.2 ± 7 | 10.3 ± 1 | 21.5 ± 2 | |
2 Gy + 20mM Metformin | 41.3 ± 0 | 16.1 ± 1 | ||
2Gy + 50µM TMZ + 1mM Metformin | 60.1 ± 7 | 8.6 ± 1 | 31.3 ± 0 | |
2Gy + 50µM TMZ + 20mM Metformin | 33.5 ± 2 | 20.0 ± 3 | ||
6Gy + 50µM TMZ | 47.1 ± 7 | 11.6 ± 3 | ||
6Gy + 1mM Metformin | 51.3 ± 2 | 10.4 ± 0 | 38.2 ± 3 | |
6Gy + 20mM Metformin | 36.1 ± 3 | 14.2 ± 0 | ||
6Gy + 50µM TMZ + 1mM Metformin | 46.3 ± 4 | 10.7 ± 1 | ||
6Gy + 50µM TMZ + 20mM Metformin | 27.9 ± 1 | 14.1 ± 3 | ||
Ctrl | 86.0 ± 2 | 3.6 ± 2 | 10.4 ± 2 | |
50µM TMZ | 37.4 ± 3 | 8.1 ± 2 | ||
1mM Metformin | 87.4 ± 3 | 3.3 ± 1 | 9.3 ± 0 | |
20mM Metformin | 63.9 ± 10 | 14.9 ± 1 | 21.2 ± 9 | |
50µM TMZ + 1mM Metformin | 38.9 ± 0 | 6.1 ± 2 | ||
50µM TMZ + 20mM Metformin | 25.2 ± 1 | 25.4 ± 2 | ||
2Gy | 83.5 ± 5 | 3.3 ± 2 | 13.2 ± 5 | |
6Gy | 67.1 ± 2 | 6.2 ± 1 | 26.7 ± 1 | |
2Gy + 50µM TMZ | 44.4 ± 1 | 6.9 ± 1 | ||
2Gy + 1mM Metformin | 82.3 ± 1 | 3.5 ± 1 | 14.2 ± 2 | |
2 Gy + 20mM Metformin | 55.6 ± 2 | 11.8 ± 2 | ||
2Gy + 50µM TMZ + 1mM Metformin | 46.0 ± 1 | 7.9 ± 1 | ||
2Gy + 50µM TMZ + 20mM Metformin | 32.3 ± 3 | 28.9 ± 7 | ||
6Gy + 50µM TMZ | 41.6 ± 2 | 8.9 ± 3 | 49.5 ± 3 | |
6Gy + 1mM Metformin | 55.5 ± 11 | 8.8 ± 4 | 35.7 ± 23 | |
6Gy + 20mM Metformin | 56.5 ± 18 | 7.8 ± 6 | 35.7 ± 16 | |
6Gy + 50µM TMZ + 1mM Metformin | 41.9 ± 2 | 5.9 ± 2 | ||
6Gy + 50µM TMZ + 20mM Metformin | 18.4 ± 1 | 16.2 ± 3 |