Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | |
---|---|---|---|---|---|
6 million IU 3 × weekly (s.c.) | 3 million IU 3 × weekly (s.c.) | 35 milion IU 20 × (i.v.) in 8 weeks/15 million IU 3× weekly (s.c.) for 13 weeks/ 10 milion IU 3 × weekly (s.c.) for 13 weeks prematurelly terminated treatment due to ineffective treatment; | 30 milion IU 20 × (i.v.) in 4 weeks followed by 15 million IU 3× weekly (s.c.) for 35 weeks followd by 10 milion IU 3 × weekly (s.c.) for 12 weeks | 30 milion IU 9 × (i.v.) in 2 weeks followed by 20 milion IU 11× (i.v.) in 3 weeks followed by 15 million IU 3× weekly (s.c.) for 13 weeks intravenous dose (i.v. dose) was decreased to 20 million IU due to pathological liver tests - prematurelly terminated treatment due to side effects | |
2 years 9 months | 7 months | 8 months | 12 months | 4 months | |
March 2004 | August 1998 | July 2012 | January 2012 | June 2011 | |
4 months | 5 years 6 months | 6 months | 3 months | 2 months | |
details on localization and number of excised metastates in paragraph Pacients’ caracteristics. | Yes | Yes | No | Yes | Yes |
4 years 8 months | 12 years 11 months | 7 months | 6 months | 7 months | |
November 2008 | July 2011 | February 2013 | July 2013 | January 2012 | |
Cisplatin | Cisplatin | Bleomycin | Bleomycin | Bleomycin | |
2 | 1 | 80 | 23 | 5 | |
1.0 × 1.5 cm 1.5 × 1.5 cm | 3 × 3 cm | 0.3–1 cm | 0.1–0.8 cm | 0.7–1.5 cm | |
CR | CR | > 85% CR | All CR | 100% PR | |
after last record date at the Institute of Oncology Ljubljana patients were given only paliative care at their regional centers | April 2010 (LRD) | December 2014 (LRD) | April 2014 (LRD) | December 2013 (D) | March 2013 (D) |
Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | |
---|---|---|---|---|---|
Male | Male | Female | Female | Female | |
1958 | 1935 | 1937 | 1953 | 1941 | |
according to AJCC TNM Cancer Staging Manual 7th edition (2010) | T3aNOMO | T2aNOMO | T4bN1aMO | T3aN1aMO | T4bN1aMO |
according to AJCC TNM Cancer Staging Manual 7th edition (2010) | Stage IIa | Stage Ib | Stage IIIb | Stage IIIa | Stage IIIb |
4 mm | 1.5 mm | 10 mm | 2.8 mm | 9.5 mm | |
/ | / | 10 mm | / | 2.5 mm | |
Right lower leg | Left foot | Right foot | Right lower leg | Back | |
Right lower leg | Left foot (dorsum) | Left lower leg | Right lower leg | Breast, left side |