The Paradox of Human Equivalent Dose Formula: A Canonical Case Study of Abrus Precatorius Aqueous Leaf Extract in Monogastric Animals

1. Ad Hoc Working Group (AHWG) (1992). Federal Coordinating Council for science, engineering and technology (FCCSET) Draft Report: A cross-section scaling factor for carcinogen risk assessment based on equivalence of mg/kg3/day. Federal Register 57: 24152 – 24173.Search in Google Scholar

2. Adedapo, A.A. (2002). Toxicological effects of some plants in the family euphorbiaceae in rats. PhD Thesis, University of Ibadan, Nigeria.Search in Google Scholar

3. Adedapo, A.A., Omoloye, O.A., Ohore, O.G. (2007). Studies on the toxicity of an aqueous extract of the leaves of Abrus precatorius in rats. Onderstepport J Vet Res. 74, 31 36. http://dx.doi.org/10.4102/ojvr.v74i1.13710.4102/ojvr.v74i1.137Search in Google Scholar

4. Adelowotan, O., Aibinu, I., Adenipekun, E., Odugbemi, T. (2008). The in vitro antimicrobial activity of Abrus precatorius (L) Fabaceae extract on some clinical pathogens. Niger Postgrad Med. J. 15 (1): 32-37. PMid:18408781Search in Google Scholar

5. Anam, E.M. (2011). Anti-inflammatory activity of compounds isolated from the aerial parts of Abrus precatorius (Fabaceae). Phytomedicine 8(1): 24-27. http://dx.doi.org/10.1078/0944-7113-00001 PMid:1129223510.1078/0944-7113-00001Search in Google Scholar

6. Anand, R.S., Kishire, V.O., Rajkumar, V. (2010). Abrus prectorius. A phytopharmacological review. J. Pharm. Res. 3(11): 2585-2587.Search in Google Scholar

7. Budavari, S. (1989). The Merak Index: An Encyclopedia of Chemicals, Drugs and Biologicals, 10th ed., Rahway, New Jersey, Merck and Co. Inc PMid:2666071Search in Google Scholar

8. Burkill, H.M. (1997). The useful plant of West Tropical Africa, Vol 11, Royal Botanical Gardens, Kew.Search in Google Scholar

9. Cheecke, P.R. (1998). Natural toxicants in feed, forage and poisonous plants. Interstate Publishers, Denville.Search in Google Scholar

10. Cheecke, P.R., Shull, L.R. (1985). Natural toxicants in feeds and poisonous plants. The Connecticut: AVI Publishing Company.Search in Google Scholar

11. Choudhari, A.B., Sayyed, N., Khairnar, A.S. (2011). Evaluation of antiserotonergic activity of ethyl acetate extract of Abrus precatorius leaves. J. Plant Res. 4(3): 570-572.Search in Google Scholar

12. Davis, J.H. (1978). Abrus precatorius (Rosary pea). The most common lethal plant poison. J. Florida Med Assoc. 65, 189-191.Search in Google Scholar

13. Dhawan, B.N., Patnaik, G.K., Singh, K.K., Tandon, J.S., Rastogi RP. (1977). Screening of Indian plants for biological activity. Indian J Exp Biol. 15, 208-219. PMid:914326Search in Google Scholar

14. Dreisbach, R.H., Robinson, W.O. (1987). Handbook of poisoning: prevention, diagnosis and treatment. Los Altos, Appleton and Lange, California 497.Search in Google Scholar

15. Faustman, E.M., Allen, B.C., Karlock, R.J., Kimmel, C.A. (1994). Dose-response assessment for developmental toxicity. 1. Characterization of database and determination of no observed adverse effect levels. Fundamental Appl. Toxicol. 23, 478-486. http://dx.doi.org/10.1006/faat.1994.113210.1006/faat.1994.1132Search in Google Scholar

16. Fernando, C. (2011). Poisoning due to Abrus precatorius (Jequirity bean). Anaesthesia 56 (12): 1178-1180.Search in Google Scholar

17. Freireich, E.J., Gehan, E.A., Rall, D. (1966). Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey and man. Cancer Chemother. Rep. 50, 219-244. PMid:4957125Search in Google Scholar

18. Frohne, D., Pfander, H.J. (1983). A colour atlas of poisonous plants. Germany Wolfe Publishing Ltd., 291. PMid:6683299Search in Google Scholar

19. Galey, F.D. (1996). Plants and other natural toxicants. In: (Smith BP. Ed), Large Animals Internal Medicine, 2nd ed., Boston: Mushby Publishers.Search in Google Scholar

20. Garg, S.K. (2005). Veterinary toxicology. New Delhi CBS publishers and Distributors, p321.Search in Google Scholar

21. Ghosal, S., Dutta, S.K. (1971). Alkaloids of Abrus precatorius. Phytochemistry 10(1): 195-198. http://dx.doi.org/10.1016/S0031-9422(00)90270-X10.1016/S0031-9422(00)90270-XSearch in Google Scholar

22. Hart, M. (1963). Jecquirity bean poisoning. N. Engl. J. Med. 268, 885-886. http://dx.doi.org/10.1056/NEJM19630418268160810.1056/NEJM196304182681608Search in Google Scholar

23. Hatts, D.S., S. Goble, R. (2002). A straw-man proposal for a quantitative definition of the reference dose. DOD conference on Toxicology risk assessment, Dayton, Ohio, 25, 2001, p 1-48.Search in Google Scholar

24. Hemadari, K., Rao, S.S. (1983). Leucorrhoea and menorrhalgia, tribal medicine, Ancient Sci. Life 3, 40-41.Search in Google Scholar

25. Hodge, H.C., Sterner, J.H. (1949). Toxicity rating. Am. Ind. Hyg. Assoc. Q. 10(4): 93. PMid:24536943Search in Google Scholar

26. Iwu, M.M. (1993). Handbook of African medicinal plants. London: CRC Press Boca Raton Ann Arbot.Search in Google Scholar

27. Kim, N.C., Kim, D.S., Kinghorn, A.D. (2002). New triterpenoids from the leaves of Abrus precatorius. Nat. Prod.Let.16 (4): 261-266. http://dx.doi.org/10.1080/10575630290020596 PMid:1216876210.1080/1057563029002059612168762Search in Google Scholar

28. Kirtikar, K.R., Basu, B.D. (1980). Indian medicinal plants. Vol. 1, Dehra Dun: International Book Distributors.Search in Google Scholar

29. Klassen, C.D. (2011). Casarett and Doall’s. Toxicology: The basic science of poisoning. 6th ed., New York: Mc Graw-Hill.Search in Google Scholar

30. Limmatvapirat, C., Sirisopanapom, Kittakoop, P. (2004). Antitubercular and antiplasmodial constituents of Abrus precatorius. Planta Med. 70 (3): 276-278. http://dx.doi.org/10.1055/s-2004-818924 PMid:1511451110.1055/s-2004-81892415114511Search in Google Scholar

31. Liu, C.L., Tsai, C.C., Lin, S.C. Wang, L.I., Hsu, C.I., Hwang, M.J., Lin, J.Y. (2000). Primary structure and function analysis of Abrus precatorius agglutinin A by site-directed mutagenesis, Pro (199) and amphiphilic alpha-helix H impairs protein synthesis inhibitory activity. J. Biol. Chem. 275 (3): 1897-1901. http://dx.doi.org/10.1074/jbc.275.3.1897 PMid:1063689010.1074/jbc.275.3.189710636890Search in Google Scholar

32. Mann, A., Gbate, M., Nda, Umar, A. (2003). Medicinal and economic plants of Nupeland. Bida: Jube Evans Books and Publications, p.191.Search in Google Scholar

33. Mordent, J. (1986). Man versus beast: pharmacokinetic scaling in mammals. J. pharmaceut. Sci.75, 1028 – 1040. http://dx.doi.org/10.1002/jps.260075110410.1002/jps.26007511043820096Search in Google Scholar

34. Premanand, R., Ganesh, T. (2010). Neuroprotective effects of Abrus precatorius Linn. Aerial extract on hypoxic neurotoxicity induced rats. Intern. J. Chem. Pharmaceut. Sci. 1(1).Search in Google Scholar

35. Rajaram, N., Janardhanan, K. (1992). The chemical composition and nutritional potential of the tribal pulse, Abrus precatorius L. plant. Foods Human Nutr. 42(94): 285-290. http://dx.doi.org/10.1007/BF0219408810.1007/BF021940881438071Search in Google Scholar

36. Reagan-Shaw, S., Nihal, M., Amhad, N. (2007). Dose translation from animal to human studies revisited. The FASEBJ 22, 659-661. http://dx.doi.org/10.1096/fj.07-9574LSF PMid:1794282610.1096/fj.07-9574LSFSearch in Google Scholar

37. Saganuwan, S.A., Onyeyili, P.A. (2012). Haematonic and plasma expander effects of aqueous leaf extract of Abrus precatorius in Mus musculus. Campar Clinical Pathol. 21(6): 1249-1255. http://dx.doi.org/10.1007/s00580-011-1274-810.1007/s00580-011-1274-8Search in Google Scholar

38. Saganuwan, S.A. (2011). A modified arithmetical method of Reed and Muench for determination of a relatively ideal median lethal dose (LD50). Afr. J. Pharm. Pharmacol. 5(12): 1543-1546. http://dx.doi.org/10.5897/AJPP11.39310.5897/AJPP11.393Search in Google Scholar

39. Saganuwan, S.A. (2012). Toxicological and antimalarial effect of aqueous leaf extract of Abrus precatorius (Jacqurity bean) in Swiss albino mice. PhD Thesis, Usmanu Danfodiyo University, Sokoto Nigeria.Search in Google Scholar

40. Saganuwan, S.A. (2012b). Principles of pharmacological calculations. 1st ed., Zaira: Ahmadu Bello University Press Ltd.Search in Google Scholar

41. Saganuwan, S.A., Gulumbe, M.L. (2005a). In vitro antimicrobial activities testing of Abrus precatorius cold water leaf extract on Salmonella typhimurium, Escherichia coli and Klebesiella pneumoniae. J. Sci. Technol. Res. 4(3): 70-73.Search in Google Scholar

42. Saganuwan, S.A., Gulumbe, M.L. (2005b). In vitro antimicrobial activities testing of Abrus precatorius cold water leaf extract on Streptococcus pyogenes and Streptococcuspneumoniae. Proc 2nd Annu Conf Nigerian Soc. Indigen Knowl Dev., 9th-12th Nov., Cross River State Univ. Technol Obubra, 93-97.Search in Google Scholar

43. Saganuwan, S.A., Onyeyili, P.A., Etuk, U.E. (2009). Acute toxicity and haematological studies of aqueous extract of Abrus precatorius leaf in Mus Musculus, African Education Initiative Conf. p65.Search in Google Scholar

44. Saganuwan, S.A., Onyeyili, P.A., Suleiman, A.O. (2011). Comparative toxicological effects of orally and intraperitoneally administered aqueous extracts of Abrus precatoriusleaf in Mus musculis. Herba Polonica 57(3): 32-44.Search in Google Scholar

45. Saganuwan, S.A., Onyeyili, P.A. (2010). Biochemical effects of aqueous leaf extract of Abrus precatorius (Jecurity bean) in Swiss albino mice. Herba Polonica 56(3): 63-80.Search in Google Scholar

46. Saganuwan, S.A., Onyeyili, P.A., Ameh, I.G., Etuk, E.U. (2011). In vivo antiplasmodial activity by aqueous extract of Abrus precatorius in mice. Rev. Latinoamer. Quin. 39(1-2): 32-34.Search in Google Scholar

47. Sawyer, N., Ratain, M.J. (2001). Body surface area as a determinant of pharmacokinetics and drug dosing. Invest New Drugs 19, 171-177. http://dx.doi.org/10.1023/A:1010639201787 PMid:1139245110.1023/A:1010639201787Search in Google Scholar

48. Sofi, M.S., Sateesh, M.K., Bashir, M., Harish, G., Lakshmeesha, T.R., Vedashree, S., Vedamurthy, A.B. (2012). Cytotoxic and pro-apoptotic effects of Abrus precatorius L. on human metastatic breast cancer cell line, NDA-NB-231. CytotechnologySearch in Google Scholar

49. Stirpe, F., Barbieri, L. (1986). Symposium: Molecular mechanisms of toxicity, toxic lectins from plants. Human Toxicol. 5(2): 108-109. http://dx.doi.org/10.1177/09603271860050020810.1177/096032718600500208Search in Google Scholar

50. Sylva, M. (1998). Interspecies allometric scaling in pharmacokinetics of drugs. Acts Pharm Hung. 68 (6): 350-354.Search in Google Scholar

51. Taur, D.J., Patil, R.Y. (2011). Effect of Abrus precatorius Leaves on milk induced leukocytosis and eosinophilia in the management of asthma. Asian Pacific J. Tropical. 1(1): 40-42. http://dx.doi.org/10.1016/S2221-1691(11)60119-610.1016/S2221-1691(11)60119-6Search in Google Scholar

52. Travis, D.C., White, R.K., Ward, R.C. (1990). Interspecies extrapolation of pharmacokinetics. J. Theoretical Biol. 142, 285 - 304. http://dx.doi.org/10.1016/S0022-5193(05)80554-510.1016/S0022-5193(05)80554-5Search in Google Scholar

53. Tripathi, S., Maith, T.K. (2005). Immunomodulatory role of native and heat denatured agglutinin from Abrus precatorius. Int. J. Biochem. Cell Biol. 37(13): 451-462. http://dx.doi.org/10.1016/j.biocel.2004.07.015 PMid:1547498910.1016/j.biocel.2004.07.015Search in Google Scholar

54. US Environmental Protection Agency (USEPA) (1986). Guideline for carcinogen risk assessment. Fed Regist 51: 3392-4003.Search in Google Scholar

55. Wambebe, C., Amosun, S.L. (1984). Some neutromuscular effects of crude extracts of the leaves of Abrus precatorius. J. Ethnopharmacol. 11(1): 49-58. http://dx.doi.org/10.1016/0378-8741(84)90095-310.1016/0378-8741(84)90095-3Search in Google Scholar

56. Watt, J.M., Breyer-Brandiwijk, A. (1962). The medicinal poisoning plants of Southern and Eastern Africa, 2nd ed., London: Livingstone publishers. PMCid:PMC1957435Search in Google Scholar

57. Xiao, Z.H., Wang, F.Z., Sun, A.J. (2011). A new triterpenoid saponin from Abrus precatorius Linn. Molecules 17(1): 295-302. http://dx.doi.org/10.3390/molecules17010295 PMid:2221016810.3390/molecules17010295629055522210168Search in Google Scholar

58. Yamba, O., Innocent, P.G., Odille, G.N. (2007). Biological and toxicological study of aqueous root-extract from Mitragyna inermis (Wild Okt) Rubiacea. Int. J. Pharmacol. 3(1): 80-85. http://dx.doi.org/10.3923/ijp.2007.80.8510.3923/ijp.2007.80.85Search in Google Scholar