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Rediscovering Don Swanson:The Past, Present and Future of Literature-based Discovery

Neil R. Smalheiser

Neil R. Smalheiser

Department of Psychiatry, University of Illinois at ChicagoChicago, USA
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Smalheiser, Neil R.
  
29 dic 2017
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Categoria dell'articolo: Expert Review
Pubblicato online: 29 dic 2017
Pagine: 43 - 64
Ricevuto: 09 ago 2017
Accettato: 13 set 2017
DOI: https://doi.org/10.1515/jdis-2017-0019
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© 2017 Walter de Gruyter GmbH, Berlin/Boston
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.
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Figure 1

Don R. Swanson.
Don R. Swanson.

Figure 2

Screenshot of UCSC Genome Browser showing the sequence for human mir-95 juxtaposed to tracks for genomic repeats. The genomic region of the mir-95 sequence corresponds to two LINE2 elements in opposite orientations. This provides evidence that, when transcribed into RNA, these LINE2 elements bind each other, creating the hairpin secondary structure that permits the processing of this sequence by enzymes (Drosha & Dicer) to form a microRNA (Smalheiser & Torvik, 2005).
Screenshot of UCSC Genome Browser showing the sequence for human mir-95 juxtaposed to tracks for genomic repeats. The genomic region of the mir-95 sequence corresponds to two LINE2 elements in opposite orientations. This provides evidence that, when transcribed into RNA, these LINE2 elements bind each other, creating the hairpin secondary structure that permits the processing of this sequence by enzymes (Drosha & Dicer) to form a microRNA (Smalheiser & Torvik, 2005).

Figure 3

Schematic diagram illustrating the one-node search. Reprinted from Swanson & Smalheiser (1997) with permission.
Schematic diagram illustrating the one-node search. Reprinted from Swanson & Smalheiser (1997) with permission.

Eight features used to characterize each B-term_

No.Feature
1Does the B-term occur in more than one paper within literatures A and C?
2Do the AB and BC sub-literatures share any MeSH terms?
3Does the B-term map to at least one UMLS semantic category?
4Does the B-term have a high literature cohesion score?
5Is the B-term moderately frequent within MEDLINE as a whole?
6Did the B-term first appear recently within MEDLINE as a whole?
7Is the B-term highly characteristic within literature A or C?
8Do the words within the B-term all occur on the customized 1,400-word stoplist?
Lingua:
Inglese
Frequenza di pubblicazione:
4 volte all'anno
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Informatica, Tecnologia informatica, Project Management, Base dati e data mining
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