<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Background</bold>: Known also as Osler’s triad, Austrian syndrome is a complex pathology which consists of pneumonia, meningitis and endocarditis, all caused by the haematogenous dissemination of Streptococcus pneumoniae. The multivalvular lesions are responsible for a severe and potential lethal outcome.<bold>Case report</bold>: The case of a 51-year-old female patient, with a past medical history of splenectomy, is presented. She developed bronchopneumonia, acute meningitis and infective endocarditis as a result of Streptococcus pneumoniae infection and subsequently developed multiple organ dysfunction syndromes which led to a fatal outcome. Bacteriological tests did not reveal the etiological agent. The histopathological examination showed a severe multivalvular endocarditis, while a PCR based molecular analysis from formalin fixed valvular tissue identified Streptococcus pneumoniae as the etiologic agent.<bold>Conclusions</bold>: The presented case shows a rare syndrome with a high risk of morbidity and mortality. Following the broad-spectrum treatment and intensive therapeutic support, the patient made unfavourable progress which raised differential diagnosis problems. In this case, the post-mortem diagnosis demonstrated multiple valvular lesions occurred as a result of endocarditis.</abstract>

Background: Known also as Osler’s triad, Austrian syndrome is a complex pathology which consists of pneumonia, meningitis and endocarditis, all caused by the haematogenous dissemination of Streptococcus pneumoniae. The multivalvular lesions are responsible for a severe and potential lethal outcome.Case report: The case of a 51-year-old female patient, with a past medical history of splenectomy, is presented. She developed bronchopneumonia, acute meningitis and infective endocarditis as a result of Streptococcus pneumoniae infection and subsequently developed multiple organ dysfunction syndromes which led to a fatal outcome. Bacteriological tests did not reveal the etiological agent. The histopathological examination showed a severe multivalvular endocarditis, while a PCR based molecular analysis from formalin fixed valvular tissue identified Streptococcus pneumoniae as the etiologic agent.Conclusions: The presented case shows a rare syndrome with a high risk of morbidity and mortality. Following the broad-spectrum treatment and intensive therapeutic support, the patient made unfavourable progress which raised differential diagnosis problems. In this case, the post-mortem diagnosis demonstrated multiple valvular lesions occurred as a result of endocarditis.

Severe Austrian Syndrome in an Immunocompromised Adult Patient – A Case Report

University of Medicine and Pharmacy of Tirgu Mures

National Institute of Infectious Diseases “Prof. Dr Matei Bals”, Laboratory of Molecular Biology

Mures County Hospital, Infectious Diseases Clinic I

Medicine University of Washington Medical Center

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Background: Known also as Osler’s triad, Austrian syndrome is a complex pathology which consists of pneumonia, meningitis and endocarditis, all caused by the...

Severe Austrian Syndrome in an Immunocompromised Adult Patient – A Case Report

Pubblicato online: 09 feb 2018

Pagine: 17 - 22

Ricevuto: 16 ago 2017

Accettato: 12 set 2017

DOI: https://doi.org/10.1515/jccm-2017-0025

Parole chiave
Austrian syndrome, multivalvular endocarditis, splenectomy

© 2017 Ioana Raluca Chirteș et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Severe Austrian Syndrome in an Immunocompromised Adult Patient – A Case Report

Pubblicato online: 09 feb 2018

Pagine: 17 - 22

Ricevuto: 16 ago 2017

Accettato: 12 set 2017

DOI: https://doi.org/10.1515/jccm-2017-0025

Parole chiaveAustrian syndrome, multivalvular endocarditis, splenectomy

© 2017 Ioana Raluca Chirteș et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Parole chiave
Austrian syndrome, multivalvular endocarditis, splenectomy