Antihypertensive Effect Of Magnesium Sulfate (Cormagnesin^®) And Its Combination With Furosemide On Conscious Spontaneously Hypertensive Rats

1. Laurant P, Touyz RM. Physiological and pathophysiological role of magnesium in the cardiovascular system: implications in hypertension. J Hypertens. 2000;18(9):1177-91.10.1097/00004872-200018090-00003Search in Google Scholar

2. Cunha AR, Umbelino B, Correia ML, Neves MF. Magnesium and vascular changes in hypertension. Int J Hypertens. 2012;2012:754250.10.1155/2012/754250Search in Google Scholar

3. Laurant P, Dalle M, Berthelot A, Rayssiguier Y. Time-course of the change in blood pressure level in magnesium-deficient Wistar rats. Br J Nutr. 1999;82(3):243-51.10.1017/S0007114599001427Search in Google Scholar

4. Touyz RM. Role of magnesium in the pathogenesis of hypertension. Mol Aspects Med. 2003;24 (1-3):107-36.10.1016/S0098-2997(02)00094-8Search in Google Scholar

5. Adrian M, Chanut E, Laurant P, Gaume V, Berthelot A. A long-term moderate magnesium-deficient diet aggravates cardiovascular risks associated with aging and increases mortality in rats. J Hypertens. 2008;26(1):44-52.10.1097/HJH.0b013e3282f09f6818090539Search in Google Scholar

6. Okamoto K, Aoki K. Development of a strain of spontaneously hypertensive rats. Jpn Circ J. 1963;27:282-93.10.1253/jcj.27.28213939773Search in Google Scholar

7. Bollman, LJ, Cain C, Grindley JH. Techniques for the collection of lymph from the liens, small intestine, or thoracic duct of the rat. J Lab Clin Med. 1948;33(10):1349-52.Search in Google Scholar

8. Higashino H, Simeonova K, Lambev I, Markov M, Suzuki A. Proper measurement of blood pressure and heart rate in SHRSP and WKY by an indirect volume-oscillometric method. Clin Exp Pharmacol Physiol. 1995;22(Suppl 1):S292-3.10.1111/j.1440-1681.1995.tb02923.x9072397Search in Google Scholar

9. Mochizuki M, Akagi K, Inoue K, Shimamura K. [A single dose toxicity of Magnesium sulfate in rats and dogs]. J Toxicol Sci. 1998;23(Suppl 1):31-5. Japanese.10.2131/jts.23.SupplementI_31Search in Google Scholar

10. Hazard R, Wurmser L. Actions des sels de magnesium sur les vasoconstricteux renaux. C.R. Seances Soc Biol. 1932;110:525-7.Search in Google Scholar

11. Touyz RM, Pu Q, He G, Chen X, Yao G, Neves MF, et al. Effects of low dietary magnesium intake on development of hypertension in stroke-prone spontaneously hypertensive rats: role of reactive oxygen species. J Hypertens. 2002;20(11):2221-32.10.1097/00004872-200211000-0002212409961Search in Google Scholar

12. Laurant P, Robin S, Berthelot A. Magnesium deficiency increases vasoconstrictor activity without affecting blood pressure of aged spontaneously hypertensive rats. Magnes Res. 1997;10(2):107-17.Search in Google Scholar

13. Altura BM, Altura BT, Gebrewold A, Ising H, Günther T. Noise-induced hypertension and magnesium in rats: relationship to microcirculation and calcium. J Appl Physiol. 1992;72(1):194-202.10.1152/jappl.1992.72.1.1941537714Search in Google Scholar

14. Altura BM, Altura BT. Magnesium and cardiovascular biology: an important link between cardiovascular risk factors and atherogenesis. Cell Mol Biol Res. 1995;41(5):347-59.Search in Google Scholar

15. Laurant P, Hayoz D, Brunner HR, Berthelot A. Effect of magnesium deficiency on blood pressure and mechanical properties of rat carotid artery. Hypertension. 1999;33(5):1105-10.10.1161/01.HYP.33.5.1105Search in Google Scholar

16. Berthon N, Laurant P, Hayoz D, Fellmann D, Brunner HR, Berthelot A. Magnesium supplementation and deoxycorticosterone acetate-salt hypertension: effect on arterial mechanical properties and on activity of endothelin-1. Can J Physiol Pharmacol. 2002;80(6):553-61.10.1139/y02-082Search in Google Scholar

17. Weglicki WB, Phillips TM, Freedman AM, Cassidy MM, Dickens BF. Magnesium-deficiency elevates circulating levels of inflammatory cytokines and endothelin. Mol Cell Biochem. 1992;110(2):169-73.10.1007/BF02454195Search in Google Scholar

18. Laurant P, Berthelot A. Influence of endothelium on Mg(2+)-induced relaxation in noradrenaline-contracted aorta from DOCA-salt hypertensive rat. Eur J Pharmacol. 1994;258:167-72.10.1016/0014-2999(94)90477-4Search in Google Scholar

19. Rayssiguier Y, Gueux E, Nowacki W, Rock E, Mazur A. High fructose consumption combined with low dietary magnesium intake may increase the incidence of the metabolic syndrome by inducing inflammation. Magnes Res. 2006;19(4):237-43.Search in Google Scholar

20. Mazur A, Maier JA, Rock E, Gueux E, Nowacki W, Rayssiguier Y. Magnesium and the inflammatory response: potential physiopathological implications. Arch Biochem Biophys. 2007;458(1):48-56.10.1016/j.abb.2006.03.031Search in Google Scholar

21. Nishio A, Gebrewold A, Altura BT, Altura BM. Comparative effects of magnesium salts on reactivity of arterioles and venules to constrictor agents: an in situ study on microcirculation. J Pharmacol Exp Ther. 1988;246(3):859-65.Search in Google Scholar

22. Berthon N, Laurant P, Fellmann D, Berthelot A. Effect of magnesium on mRNA expression and production of endothelin-1 in DOCA-salt hypertensive rats. J Cardiovasc Pharmacol. 2003;42(1):24-31.10.1097/00005344-200307000-00004Search in Google Scholar

23. Dettmann ES, Lüscher TF, Flammer J, Haefliger IO. Modulation of endothelin-1-induced contractions by magnesium/calcium in porcine ciliary arteries. Graefes Arch Clin Exp Ophthalmol. 1998;236(1):47-51.10.1007/s004170050041Search in Google Scholar

24. Kemp PA, Gardiner SM, Bennett T, Rubin PC. Magnesium sulphate reverses carotid vasoconstriction caused by endothelin-1, angiotensin II and neuropeptide-Y, but not that caused by N^G-nitro-L-arginine methyl ester, in conscious rats. Clin Sci. 1993;85:175-81.10.1042/cs0850175Search in Google Scholar

25. Laurant P, Berthelot A. Influence of endothelium on Mg(2+)-induced relaxation in noradrenaline-contracted aorta from DOCA-salt hypertensive rat. Eur J Pharmacol. 1994;258(3):167-72.10.1016/0014-2999(94)90477-4Search in Google Scholar

26. Briel RC, Lippert TH, Zahradnik HP. [Changes in blood coagulation, thrombocyte function and vascular prostacyclin synthesis caused by magnesium sulfate]. Geburtshilfe Frauenheilkd. 1987;47(5):332-6. German.Search in Google Scholar

27. Resnick LM, Militianu D, Cunnings AJ, Pipe JG, Evelhoch JL, Soulen RL. Direct magnetic resonance determination of aortic distensibility in essential hypertension: relation to age, abdominal visceral fat, and in situ intracellular free magnesium. Hypertension. 1997;30(3 Pt 2):654-9.10.1161/01.HYP.30.3.654Search in Google Scholar

28. Yang ZW, Gebrewold A, Nowakowski M, Altura BT, Altura BM. Mg(2+)-induced endothelium-dependent relaxation of blood vessels and blood pressure lowering: role of NO. Am J Physiol Regul Integr Comp Physiol. 2000;278(3):R628-39.10.1152/ajpregu.2000.278.3.R62810712282Search in Google Scholar

29. Vilskersts R, Kuka J, Liepinsh E, Cirule H, Gulbe A, Kalvinsh I, Dambrova M. Magnesium nitrate attenuates blood pressure rise in SHR rats. Magnes Res. 2014;27(1):16-24.10.1684/mrh.2014.035824827813Search in Google Scholar

30. Touyz MR, Milne FJ, Reinach GS. Intracellular Mg2+, Ca2+, Na+ and K+ in platelets and erythrocytes of essential hypertension patients: relation to blood pressure. Clin Exp Hypertens A. 1992; 14(6):1189-209.Search in Google Scholar

31. Laurant P, Kantelip JP, Berthelot A. Dietary magnesium supplementation modifies blood pressure and cardiovascular function in mineralocorticoid-salt hypertensive rats but not in normotensive rats. J Nutr. 1995;125(4):830-41.Search in Google Scholar

32. Jin K, Kim TH, Kim YH, Kim YW. Additional antihypertensive effect of magnesium supplementation with an angiotensin II receptor blocker in hypomagnesemic rats. Corean J Intern Med. 2013;28(2):197-205.10.3904/kjim.2013.28.2.197360461023526071Search in Google Scholar

33. Makynen H, Kahonen M, Arvola P, Wuorela H, Vapaatalo H, Porsti I. Dietary calcium and magnesium supplements in spontaneously hypertensive rats and isolated arterial reactivity. Br J Pharmacol. 1995;115(8):1455-62.10.1111/j.1476-5381.1995.tb16637.x19088818564205Search in Google Scholar

34. Katz A, Rosenthal T, Maoz C, Peleg E, Zeidenstein R, Levi Y. Effect of a mineral salt diet on 24 hr blood pressure monitoring in elderly hypertensive patients. J Hum Hypertens. 1999;13(11):777-80.10.1038/sj.jhh.100083710578223Search in Google Scholar