[Benotti, M.J., Trenholm, R.A., Vanderford, B.J., Holady, J.C., Stanford, B.D. and Snyder, S.A. 2009. Pharmaceuticals and endocrine disrupting compounds in U.S. drinking water. Environmental Science & Technology, 43: 597-603.]Search in Google Scholar
[Bioanalytical-Validation, Guidance for Industry: Bioanalytical Method Validation. http://www.fda.gov/downloads/Drugs/Guidances/ucm070107.pdf, accessed at 25-05-2015.]Search in Google Scholar
[Bosch-Ojeda, C. and Sanchez-Rojas, F. 2009. Separation and Preconcentration by Dispersive Liquid- Liquid Microextraction Procedure: A Review. Chromatographia, 69: 1-11.10.1365/s10337-009-1104-1]Search in Google Scholar
[Bouchard, M.F., Chevrier, J., Harley, K.G., Kogut, K., Vedar, M., Calderon, N., Trujillo, C., Johnson, C., Bradman, A., Barr, D.B. and Eskenazi, B. 2011. Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children. Environmental Health Perspectives, 119: 1189-1195.]Search in Google Scholar
[Chen, S.C. and Liao, C.M. 2006. Health risk assessment on human exposed to environmental polycyclic aromatic hydrocarbons pollution sources. Science of the Total Environment, 366: 112-123.]Search in Google Scholar
[David, D., George, I.A. and Peter, J.V. 2007. Toxicology of the newer neonicotinoid insecticides: imidacloprid poisoning in a human. Clinical Toxicology, 45: 485-486.]Search in Google Scholar
[Dawson, A.H., Eddleston, M., Senarathna, L., Mohamed, F., Gawarammana, I., Bowe, S.J., Manuweera, G. and Buckley, N.A. 2010. Acute human lethal toxicity of agricultural pesticides: a prospective cohort study. PLoS Medicine, 7: e1000357.10.1371/journal.pmed.1000357296434021048990]Search in Google Scholar
[Decourtye, A., Armengaud, C., Renou, M., Devillers, J., Cluzeau, S., Gauthier, M. and Pham-Delegue, M-H. 2003. Imidacloprid impairs memory and brain metabolism in the honeybee (Apis mellifera L.). Pesticide Biochemistry and Physiology, 78: 83-92. ]Search in Google Scholar
[de Pinho, G.P., Neves, A.A., de Queiroz, M.E.L.R. and Silverio, F.O. 2010. Optimization of the liquid- liquid extraction method and low temperature purifi cation (LLE-LTP) for pesticide residue analysis in honey samples by gas chromatography. Food Control, 21: 1307-1311.]Search in Google Scholar
[Dockery, D.W. and Pope, C.A. 3rd. 1994. Acute respiratory eff ects of particulate air pollution. Annual Review of Public Health, 15: 107-132.]Search in Google Scholar
[Domingo, J.L., Marti-Cid, R., Castell, V. and Llobet, J.M.. 2008. Human exposure to PBDEs through the diet in Catalonia, Spain: temporal trend. A review of recent literature on dietary PBDE intake. Toxicology, 248: 25-32.]Search in Google Scholar
[ECOPEST, http://www.ecopest.gr/index.php?lang=en.accessed at 25-05-2015.]Search in Google Scholar
[Engel, S.M., Berkowitz, G.S., Barr, D.B., Teitelbaum, S.L., Siskind, J., Meisel, S.J., Wetmur, J.G. and Wolff , M.S., 2007. Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort. American Journal of Epidemiology, 165: 1397-1404.10.1093/aje/kwm02917406008]Search in Google Scholar
[Forrester, M. 2014. Neonicotinoid insecticide exposures reported to six poison centers in Texas. Human & Experimental Toxicology, 33: 568-573.]Search in Google Scholar
[Fuke, C., Nagai, T., Ninomiya, K., Fukasawa, M., Ihama, Y. and Miyazaki, T. 2014. Detection of imidacloprid in biological fl uids in a case of fatal insecticide intoxication. Legal Medicine, 16: 40-43.]Search in Google Scholar
[Gagliardi, B. and Pettigrove, V. 2013. Removal of Intensive Agriculture from the Landscape Improves Aquatic Ecosystem Health. Agriculture, Ecosystems and Environment, 176: 1-8.]Search in Google Scholar
[Goulson, D., Nicholls, E., Botias, C. and Rotheray, E.L. 2015. Bee declines driven by combined stress from parasites, pesticides, and lack of fl owers. Science 347: no. 622910.1126/science.125595725721506]Search in Google Scholar
[Gunnell, D. and Eddleston, M. 2003. Suicide by intentional ingestion of pesticides: a continuing tragedy in developing countries. International Journal of Epidemiology, 32: 902-909.]Search in Google Scholar
[Hatjina, F., Papaefthimiou, C., Charistos, L., Dogaroglu, T., Bouga, M., Emmanouil, C. and Arnold, G. 2013. Sublethal doses of imidacloprid decreased size of hypopharyngeal glands and respiratory rhythm of honeybees in vivo. Apidologie, 44: 467-480.]Search in Google Scholar
[Hernandez, F., Sancho, J.V. and Pozo, O.J., 2005. Critical review of the application of liquid chromatography/ mass spectrometry to the determination of pesticide residues in biological samples. Analytical and Bioanalytical Chemistry, 382: 934-946.10.1007/s00216-005-3185-515915347]Search in Google Scholar
[ICH, 2005. Validation of Analytical Procedures: Text and Methodology Q2(R1) http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Quality/Q2_R1/Step4/Q2_R1__Guideline.pdf.]Search in Google Scholar
[Inoue, S., Saito, T., Mase, H., Suzuki, Y., Takazawa, K., Yamamoto, I. and Inokuchi, S. 2007. Rapid simultaneous determination for organophosphorus pesticides in human serum by LC-MS. Journal of Pharmaceutical and Biomedical Analysis, 44: 258-264.]Search in Google Scholar
[Iyyadurai, R., George, I.A. and Peter, J.V. 2010. Imidacloprid poisoning--newer insecticide and fatal toxicity. Journal of Medical Toxicology, 6: 77-78.]Search in Google Scholar
[Jamin, E.L., Bonvallot, N., Tremblay-Franco, M., Cravedi, J.P., Chevrier, C., Cordier, S. and Debrauwer, L. 2014. Untargeted profi ling of pesticide metabolites by LC-HRMS: an exposomics tool for human exposure evaluation. Analytical and Bioanalytical Chemistry, 406: 1149-1161.]Search in Google Scholar
[Jia, G., Lv, C., Zhu, W., Qiu, J., Wang, X. and Zhou, Z. 2008. Applicability of cloud point extraction coupled with microwave-assisted back-extraction to the determination of organophosphorous pesticides in human urine by gas chromatography with fl ame photometry detection. Journal of Hazardous Materials, 159: 300-305.]Search in Google Scholar
[Jones, A.K. and Sattelle, D.B. 2010. Diversity of Insect Nicotinic Acetylcholine Receptor Subunits. Pp. 25-43. In: Insect Nicotinic Acetylcholine Receptors, Advances in Experimental Medicine and Biology series, Vol 683 (Thany, S.H., ed.) Springer Science & Business Media, LLC, Landes Bioscience, New York, USA.10.1007/978-1-4419-6445-8_320737786]Search in Google Scholar
[Kasiotis, K.M., Kyriakopoulou, K., Emmanouil, C., Tsantila, N., Liesivuori, J., Souki, H., Manakis, S. and Machera, K. 2012. Monitoring of systemic exposure to plant protection products and DNA damage in orchard workers. Toxicology Letters, 210: 182-188.]Search in Google Scholar
[Kasiotis, K.M., Souki, H., Carageorgiou, H. and Machera, K. 2011. Determination of dimethoate and omethoate in human serum samples. Risk assessment for the operator. International Journal of Environmental Analytical Chemistry, 91: 876-883.]Search in Google Scholar
[Kasiotis, K.M., Souki, H., Tsakirakis, A.N., Carageorgiou, H., Theotokatos, S.A., Haroutounian, S.A., Machera, K. 2008. Headspace solid phase micro extraction gas chromatographic determination of fenthion in human serum. International Journal of Molecular Sciences, 9: 906-913.]Search in Google Scholar
[Kataoka, H. 2003. New trends in sample preparation for clinical and pharmaceutical analysis. Trends in Analytical Chemistry, 22: 232-244.]Search in Google Scholar
[Kole, P.L., Venkatesh, G., Kotecha, J. and Sheshala, R. 2011. Recent advances in sample preparation techniques for eff ective bioanalytical methods. Biomedical Chromatography: BMC, 25: 199-217.]Search in Google Scholar
[Kong, Y. and Zhang, J. 2010. Access to farming pesticides and risk for suicide in Chinese rural young people. Psychiatry Research, 179: 217-221.]Search in Google Scholar
[Kumar, A., Verma, A. and Kumar, A. 2013. Accidental human poisoning with a neonicotinoid insecticide, imidacloprid: A rare case report from rural India with a brief review of literature. Egyptian Journal of Forensic Sciences, 3: 123-126. ]Search in Google Scholar
[La Farre, M., Perez, S., Kantiani, L. and Barcelo, D. 2008. Fate and toxicity of emerging pollutants, their metabolites and transformation products in the aquatic environment. Trends in Analytical Chemistry, 27: 991-1007.]Search in Google Scholar
[Li, M. 2013. Automation in the bioanalytical laboratory: what is the future? Bioanalysis, 5: 2859-2861.]Search in Google Scholar
[Li, M., Chou, J., King, K.W. and Yang, L. 2013. ASPECTS: an automation-assisted SPE method development system. Bioanalysis, 5: 1661-1676.10.4155/bio.13.13623822129]Search in Google Scholar
[Lin, P.C., Lin, H.J., Liao, Y.Y., Guo, H.R. and Chen, K.T. 2013. Acute poisoning with neonicotinoid insecticides: a case report and literature review. Basic & Clinical Pharmacology & Toxicology, 112: 282-286.]Search in Google Scholar
[Lu, C., Barr, D.B., Pearson, M.A. and Waller, L.A. 2008. Dietary intake and its contribution to longitudinal organophosphorus pesticide exposure in urban/suburban children. Environmental Health Perspectives, 116: 537-542.]Search in Google Scholar
[Lu, C., Warchol, K.M. and Callahan, R.A. 2014. Sub-lethal exposure to neonicotinoids impaired honey bees winterization before proceeding to colony collapse disorder. Bulletin of Insectology, 67: 125-130.]Search in Google Scholar
[Marti-Cid, R., Llobet, J.M., Castell, V. and Domingo, J.L. 2008a. Evolution of the dietary exposure to polycyclic aromatic hydrocarbons in Catalonia, Spain. Food and Chemical Toxicology, 46: 3163-3171.]Search in Google Scholar
[Marti-Cid, R., Llobet, J.M., Castell, V. and Domin go, J.L. 2008b. Human dietary exposure to hexachlorobenzene in Catalonia, Spain. Journal of Food Protection, 71: 2148-2152.]Search in Google Scholar
[Marti-Cid, R., Llobet, J.M., Castell, V. and Domingo, J.L. 2008c. Human exposure to polychlorinated naphthalenes and polychlorinated diphenyl ethers from foods in Catalonia, Spain: temporal trend. Environmental Science & Technology, 42: 4195-4201.]Search in Google Scholar
[Matsuda, K., Shimomura, M., Ihara, M., Akamatsu, M. and Sattelle, D.B. 2005. Neonicotinoids show selective and diverse actions on their nicotinic receptor targets: electrophysiology, molecular biology, and receptor modeling studies. Bioscience, Biotechnology, and Biochemistry, 69: 1442-1452.]Search in Google Scholar
[Mohamed, F., Gawarammana, I., Robertson, T.A., Roberts, M.S., Palangasinghe, C., Zawahir, S., Jayamanne, S., Kandasamy, J., Eddleston, M., Buckley, N.A., Dawson, A.H. and Roberts, D.M. 2009. Acute human self-poisoning with imidacloprid compound: a neonicotinoid insecticide. PloS one, 4: e5127.10.1371/journal.pone.0005127266242419352499]Search in Google Scholar
[Nauen, R., Ebbinghaus-Kintscher, U. and Schmuck, R. 2001. Toxicity and nicotinic acetylcholine receptor interaction of imidacloprid and its metabolites in Apis mellifera (Hymenoptera: Apidae). Pest Management Science, 57: 577-586.]Search in Google Scholar
[Nomura, H., Ueyama, J., Kondo, T., Saito, I., Murata, K., Iwata, T., Wakusawa, S. and Kamijima, M. 2013. Quantitation of neonicotinoid metabolites in human urine using GC-MS. Journal of Chromatography, B 941: 109-115.]Search in Google Scholar
[Parron, T., Hernandez, A.F. and Villanueva, E. 1996. Increased risk of suicide with exposure to pesticides in an intensive agricultural area. A 12- year retrospective study. Forensic Science International, 79: 53-63.]Search in Google Scholar
[Pollack, P. 2011. Fine chemicals: the industry and the business, 2nd edition ed. John Wiley & Sons, New Jersey.]Search in Google Scholar
[Proenca, P., Teixeira, H., Castanheira, F., Pinheiro, J., Monsanto, P.V., Marques, E.P. and Vieira, D.N. 2005. Two fatal intoxication cases with imidacloprid: LC/MS analysis. Forensic Science International, 153: 75-80.]Search in Google Scholar
[Ramanathan, R., Jemal, M., Ramagiri, S., Xia, Y.Q., Humpreys, W.G., Olah, T., Korfmacher, W.A., 2011. It is time for a paradigm shift in drug discovery bioanalysis: from SRM to HRMS. Journal of Mass Spectrometry, 46: 595-601.10.1002/jms.192121630388]Search in Google Scholar
[Simon-Delso, N., Amaral-Rogers, V., Belzunces, L.P., Bonmatin, J.M., Chagnon, M., Downs, C., Furlan, L., Gibbons, D.W., Giorio, C., Girolami, V., Goulson, D., Kreutzweiser, D.P., Krupke, C.H., Liess, M., Long, E., McField, M., Mineau, P., Mitchell, E.A., Morrissey, C.A., Noome, D.A., Pisa, L., Settele, J., Stark, J.D., Tapparo, A., Van Dyck, H., Van Praagh, J., Van der Sluijs, J.P., Whitehorn, P.R. and Wiemers, M. 2015. Systemic insecticides (neonicotinoids and fi pronil): trends, uses, mode of action and metabolites. Environmental Science and Pollution Research, 22: 5-34.]Search in Google Scholar
[Taira, K. 2014. Human neonicotinoids exposure in Japan. Japanese Journal of Clinical Ecology, 23: 14-24.]Search in Google Scholar
[Taira, K., Aoyama, Y., Kawakami, T., Kamata, M. and Aoi, T. 2011. Detection of chrolopyridinyl neonicotinoid insecticide metbolite 6-chloronicotinic aicd in the urine: Six cases with subacute nicotinic symptoms. Japan Journal of Clinical Toxicology, 24: 222-230.]Search in Google Scholar
[Taira, K., Fujioka, K. and Aoyama, Y. 2013. Qualitative profi ling and quantifi cation of neonicotinoid metabolites in human urine by liquid chromatography coupled with mass spectrometry. PloS one, 8: e80332.]Search in Google Scholar
[Togola, A., Baran, N. and Coureau, C. 2014. Advantages of online SPE coupled with UPLC/MS/MS for determining the fate of pesticides and pharmaceutical compounds. Analytical and Bioanalytical Chemistry, 406: 1181-1191.]Search in Google Scholar
[Tomizawa, M., Maltby, D., Medzihradszky, K.F., Zhang, N., Durkin, K.A., Presley, J., Talley, T.T., Taylor, P., Burlingame, A.L. and Casida, J.E. 2007a. Defi ning nicotinic agonist binding surfaces through photoaffi nity labeling. Biochemistry, 46: 8798-8806.]Search in Google Scholar
[Tomizawa, M., Talley, T.T., Maltby, D., Durkin, K.A., Medzihradszky, K.F., Burlingame, A.L., Taylor, P. and Casida, J.E. 2007b. Mapping the elusive neonicotinoid binding site. Proceedings of the National Academy of Sciences of the United States of America, 104: 9075-9080.]Search in Google Scholar
[Ueyama, J., Nomura, H., Kondo, T., Saito, I., Ito, Y., Osaka, A. and Kamijima, M. 2014. Biological monitoring method for urinary neonicotinoid insecticides using LC-MS/MS and its application to Japanese adults. Journal of Occupational Health, 56: 461-468.]Search in Google Scholar
[Uroz, F.J., Arrebola, F.J., Egea-Gonzalez, F.J. and Martinez- Vidal, J.L. 2001. Monitoring of 6-chloronicotinic acid in human urine by gas chromatography- tandem mass spectrometry as indicator of exposure to the pesticide imidacloprid. Analyst, 126: 1355-1358.10.1039/b101167g11534604]Search in Google Scholar
[Van Eeckhaut, A., Lanckmans, K., Sarre, S., Smolders, I. and Michotte, Y. 2009. Validation of bioanalytical LC-MS/MS assays: evaluation of matrix eff ects. Journal of Chromatography B, 877: 2198-2207.]Search in Google Scholar
[Vanengelsdorp, D., Evans, J.D., Saegerman, C., Mullin, C., Haubruge, E., Nguyen, B.K., Frazier, M., Frazier, J., Cox-Foster, D., Chen, Y., Underwood, R., Tarpy, D.R. and Pettis, J.S. 2009. Colony collapse disorder: a descriptive study. PloS one, 4: e6481.]Search in Google Scholar
[Wu, I.W., Lin, J.L., Cheng, E.T., 2001. Acute poisoning with the neonicotinoid insecticide imidacloprid in N-methyl pyrrolidone. Clinical Toxicology, 39: 617-621.10.1081/CLT-100108494]Search in Google Scholar
[Xiao, J.F., Zhou, B. and Ressom, H.W. 2012. Metabolite identifi cation and quantitation in LC-MS/ MS-based metabolomics. Trends in Analytical Chemistry, 32: 1-14.]Search in Google Scholar
[Yamamuro, T., Ohta, H., Aoyama, M. and Watanabe, D., 2014. Simultaneous determination of neonicotinoid insecticides in humanserum and urine using diatomaceous earth-assisted extraction andliquid chromatography-tandem mass spectrometry. Journal of Chromatography, B 969: 85-94.10.1016/j.jchromb.2014.06.00825168791]Search in Google Scholar
[Yeh, I.J., Lin, T.J., Hwang, D.Y., 2010. Acute multiple organ failure with imidacloprid and alcohol ingestion. The American Journal of Emergency Medicine, 28, 255 e251-253.10.1016/j.ajem.2009.05.00620159407]Search in Google Scholar
[Yeter, O., Aydin, A., 2014. Determination of acetamiprid and IM-1-2 in postmortem human blood, liver, stomach contents by HPLC-DAD. Journal of Forensic Sciences, 59: 287-292. 10.1111/1556-4029.1236824329162]Search in Google Scholar