<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_fco-2015-0027_s_006_w2aab3b7b3b1b6b1aab1c16b1Aa"><h3>Aim</h3><p>This trial aimed to determine wether postoperative radioactive iodine(RAI) associated with a survival benefit among intermediate-risk Papillary Thyroid Cancer patients or not.</p></sec><sec id="j_fco-2015-0027_s_007_w2aab3b7b3b1b6b1aab1c16b2Aa"><h3>Methods</h3><p>this study is a retrospective study of intermediate-risk papillary thyroid cancer patients that were treated with or without post operative RAI from 1st January 2002 till 1st January 2012. Overall survival (OS) and multivariate regression analyses were measured for all patients.</p></sec><sec id="j_fco-2015-0027_s_008_w2aab3b7b3b1b6b1aab1c16b3Aa"><h3>Results</h3><p>100 patients were included in this trial : 70 patients received postoperative RAI and 30 patients did not. The mean follow-up time was 7.1 (4.8 -15.1 years), and a median survival time could not be estimated. Overall survival at 10 years was 96% in the RAI vs 93% in the group without RAI (P &lt; .001). RAI reduced risk of death by a 27% [hazard risk (HR) 0.73, confidence interval (CI) 0.64 - 0.84, P &lt; .001]. Older patient age, male gende, larger tumor size, multifocal tumors, lymph node metastases, aggressive histology, vascular invasion, positive surgical margin, minimal extrathyroidal extension and absence of postoperative RAI were accompanied by compromised OS (all P ≤ .001).</p></sec><sec id="j_fco-2015-0027_s_009_w2aab3b7b3b1b6b1aab1c16b4Aa"><h3>Conclusion</h3><p>This representative study addresses the survival advantage of RAI for with intermediate risk PTC patients but conducting of large prospective randomized controlled trial is still warranted.</p></sec></abstract>

AimThis trial aimed to determine wether postoperative radioactive iodine(RAI) associated with a survival benefit among intermediate-risk Papillary Thyroid Cancer patients or not.Methodsthis study is a retrospective study of intermediate-risk papillary thyroid cancer patients that were treated with or without post operative RAI from 1st January 2002 till 1st January 2012. Overall survival (OS) and multivariate regression analyses were measured for all patients.Results100 patients were included in this trial : 70 patients received postoperative RAI and 30 patients did not. The mean follow-up time was 7.1 (4.8 -15.1 years), and a median survival time could not be estimated. Overall survival at 10 years was 96% in the RAI vs 93% in the group without RAI (P < .001). RAI reduced risk of death by a 27% [hazard risk (HR) 0.73, confidence interval (CI) 0.64 - 0.84, P < .001]. Older patient age, male gende, larger tumor size, multifocal tumors, lymph node metastases, aggressive histology, vascular invasion, positive surgical margin, minimal extrathyroidal extension and absence of postoperative RAI were accompanied by compromised OS (all P ≤ .001).ConclusionThis representative study addresses the survival advantage of RAI for with intermediate risk PTC patients but conducting of large prospective randomized controlled trial is still warranted.

Is postoperative radioactive iodine associated with a survival advantage among…

Forum of Clinical Oncology

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

AimThis trial aimed to determine wether postoperative radioactive iodine(RAI) associated with a survival benefit among intermediate-risk Papillary Thyroid...

Is postoperative radioactive iodine associated with a survival advantage among…

Pubblicato online: 30 giu 2017

Pagine: 23 - 27

Ricevuto: 11 apr 2017

Accettato: 24 ago 2017

DOI: https://doi.org/10.1515/fco-2015-0027

Parole chiave
Postoperative radioactive iodine, intermediate-risk Papillary Thyroid Cancer

© 2017 Rasha Hamdy Hamed

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Is postoperative radioactive iodine associated with a survival advantage among…

Pubblicato online: 30 giu 2017

Pagine: 23 - 27

Ricevuto: 11 apr 2017

Accettato: 24 ago 2017

DOI: https://doi.org/10.1515/fco-2015-0027

Parole chiavePostoperative radioactive iodine, intermediate-risk Papillary Thyroid Cancer

© 2017 Rasha Hamdy Hamed

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Parole chiave
Postoperative radioactive iodine, intermediate-risk Papillary Thyroid Cancer