The effects of Curcuma longa and curcumin on reproductive systems

Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 23, 363-398, 2003.Search in Google Scholar

Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S, Aggarwal BB. Curcumin (diferuloylmethane) downregulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IκBα kinase and Akt activation. Mol Pharmacol 69, 195-206, 2006.10.1124/mol.105.01740016219905Search in Google Scholar

Agga rwal BB, Harikumar KB. Potential therapeutic eff ects of curcumin, the anti-infl ammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 41, 40-59, 2009.10.1016/j.biocel.2008.06.010263780818662800Open DOISearch in Google Scholar

Akram M, Uddin S, Ahmed A, Usmanghani K, Hannan A, Mohiuddin E, Asif M. Curcuma longa and curcumin: a review article. Rom J Biol Plant Biol 55, 65-70, 2010.Search in Google Scholar

Akta s C, Kanter M, Erboga M, Ozturk S. Anti-apoptotic eff ects of curcumin on cadmium-induced apoptosis in rat testes. Toxicol Indust Health 28, 122-130, 2012.10.1177/074823371140724221632575Search in Google Scholar

Ammo n HP, Wahl MA. Pharmacology of Curcuma longa. Plant Med 57, 1-7, 1991.10.1055/s-2006-9600042062949Search in Google Scholar

Arau jo CAC, Leon LL. Biological activities of Curcuma longa L. Memorias do Instituto Oswaldo Cruz 96, 723-728, 2001.10.1590/S0074-0276200100050002611500779Search in Google Scholar

Asho k P, Meenakshi B. Contraceptive eff ect of Curcuma longa (L.) in male albino rat. Asia J Androl 6, 71-74, 2004.Search in Google Scholar

Azza M, El-Wakf ME-S, Elhabiby MW, El-kholy E-GEA. Use of tumeric and curcumin to alleviate adverse reproductive outcomes of water: Nitrate pollution in male rats. Nat Sci 9, 229-239, 2011.Search in Google Scholar

Chai nani-Wu N. Safety and anti-infl ammatory activity of curcumin: a component of tumeric (Curcuma longa). J Alter Compl Med 9, 161-168, 2003.10.1089/10755530332122303512676044Search in Google Scholar

Cohe n GM. Caspases: the executioners of apoptosis. Biochem J 326, 1-16, 1997.10.1042/bj326000112186309337844Search in Google Scholar

Cort A, Timur M, Ozdemir E, Kucuksayan E, Ozben T. Synergistic anticancer activity of curcumin and bleomycin: an in vitro study using human malignant testicular germ cells. Mol Med Rep 5, 1481-1146, 2012.Search in Google Scholar

Cort A, Timur M, Ozdemir E, Ozben T. Eff ects of curcumin on bleomycin-induced apoptosis in human malignant testicular germ cells. J Physiol Biochem 69, 289-296, 2013.10.1007/s13105-012-0211-x23001851Search in Google Scholar

Cragg GM, Newman DJ. Plants as a source of anti-cancer agents. J Ethnopharmacol 100, 72-79, 2005.10.1016/j.jep.2005.05.01116009521Open DOISearch in Google Scholar

Desh pande UR, Gadre SG, Raste AS, Pillai D, Bhide SV, Samuel AM. Protective eff ect of turmeric (Curcuma long L.) extract on carbon tetrachloride-induced liver damage in rats. India J Exp Biol 36, 573-577, 1998.Search in Google Scholar

Dobrovolskaia MA, Kozlov SV. Infl ammation and cancer: when NF-κB amalgamates the perilous partnership. Curr Cancer Drug Targets 5, 325-344, 2005.10.2174/156800905462964516101381Open DOISearch in Google Scholar

Dorai T, Cao YC, Dorai B, Buttyan R, Katz AE. Th erapeutic potential of curcumin in human prostate cancer. III.Search in Google Scholar

Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Prostate 47, 293-303, 2001.1139817710.1002/pros.1074Search in Google Scholar

Eigner D, Scholz D. Ferula asa-foetida and Curcuma longa in traditional medical treatment and diet in Nepal. J Ethnopharmacol 67, 1-6, 1999.10.1016/S0378-8741(98)00234-7Search in Google Scholar

Farombi EO, Abarikwu SO, Adedara IA, Oyeyemi MO. Curcumin and kolaviron ameliorate di‐n‐butylphthalate‐induced testicular damage in rats. Basic Clin Pharmacol Toxicol 100, 43-48, 2007.10.1111/j.1742-7843.2007.00005.xOpen DOISearch in Google Scholar

Giannessi F, Giambelluca MA, Grasso L, Scavuzzo MC, Ruff oli R. Curcumin protects Leydig cells of mice from damage induced by chronic alcohol administration. Med Sci Monitor 14, BR237-BR242, 2008.Search in Google Scholar

Gururaj A, Belakavadi M, Venkatesh DA, Marme D, Salimath BP. Molecular mechanisms of antiangiogenic eff ect of curcumin. Biochem Biophys Res Commun 297, 934-942, 2002.10.1016/S0006-291X(02)02306-9Search in Google Scholar

Hardie DG, C arling D. Th e AMP‐activated protein kinase. Eur J Biochem 246, 259-273, 1997.10.1111/j.1432-1033.1997.00259.x9208914Search in Google Scholar

Harris SL, Le vine AJ. Th e p53 pathway: positive and negative feedback loops. Oncogene 24, 2899-2908, 2005.10.1038/sj.onc.120861515838523Open DOISearch in Google Scholar

Holt PR, Katz S, Kirshoff R. Curcumin therapy in infl ammatory bowel disease: a pilot study. Dig Dis Sci 50, 2191-2193, 2005.10.1007/s10620-005-3032-816240238Open DOISearch in Google Scholar

Hu M, Du Q, V ancurova I, Lin X, Miller EJ, Simms HH, Wang P. Proapoptotic eff ect of curcumin on human neutrophils: activation of the p38 mitogen-activated protein kinase pathway. Crit Care Med 33, 2571-2578, 2005.10.1097/01.CCM.0000186760.20502.C7Open DOISearch in Google Scholar

Hu J, Verkman A. Increased migration and metastatic potential of tumor cells expressing aquaporin water channels. FASEB J 20, 1892-1894, 2006.10.1096/fj.06-5930fje16818469Open DOISearch in Google Scholar

Ilbey YO, Ozb ek E, Cekmen M, Simsek A, Otunctemur A, Somay A. Protective eff ect of curcumin in cisplatininduced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways. Hum Reprod 24, 1717-1725, 2009.10.1093/humrep/dep05819279034Open DOISearch in Google Scholar

Ji C, Cao C, Lu S, Kivlin R, Amaral A, Kouttab N, Yang H, Chu W, Bi Z, Di W, Wan Y. Curcumin attenuates EGFinduced AQP3 up-regulation and cell migration in human ovarian cancer cells. Cancer Chemother Pharmacol 62, 857-865, 2008.10.1007/s00280-007-0674-6Search in Google Scholar

Jurenka JS. A nti-infl ammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev 14, 141-153, 2009.Search in Google Scholar

Khazdair MR, Mohebbati R, Karimi S, Abbasnezhad A, Haghshenas M. Th e protective eff ects of Curcuma longa extract on oxidative stress markers in the liver induced by Adriamycin in rat. Physiol Pharmacol 20, 31-37, 2016.Search in Google Scholar

Kowluru RA, K anwar M. Eff ects of curcumin on retinal oxidative stress and infl ammation in diabetes. Nutr Metab (Lond) 4, 8, 2007.10.1186/1743-7075-4-8Search in Google Scholar

Kunchandy E, Rao MNA. Oxygen radical scavenging activity of curcumin. Int J Pharm 58, 237-240, 1990.10.1016/0378-5173(90)90201-EOpen DOISearch in Google Scholar

Kuttan R, Bha numathy P, Nirmala K, George MC. Potential anticancer activity of turmeric (Curcuma longa). Cancer Lett 29, 197-202, 1985.10.1016/0304-3835(85)90159-4Open DOISearch in Google Scholar

Lantz RC, Che n G, Solyom A, Jolad S, Timmermann B. Th e eff ect of turmeric extracts on infl ammatory mediator production. Phytomedicine 12, 445-452, 2005.10.1016/j.phymed.2003.12.01116008121Open DOISearch in Google Scholar

Lin YG, Kunnu makkara AB, Nair A, Merritt WM, Han LY, Armaiz-Pena GN, Kamat AA, Spannuth WA, Gershenson DM, Lutgendorf SK, Aggarwal BB, Sood AK. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-κB pathway. Clin Cancer Res 13, 3423-3430, 2007.10.1158/1078-0432.CCR-06-307217545551Open DOISearch in Google Scholar

Martelli AM, Z weyer M, Ochs RL, Tazzari PL, Tabellini G, Narducci P, Bortul R. Nuclear apoptotic changes: an overview.J Cell Biochem 82, 634-646, 2001. 10.1002/jcb.118611500941Open DOISearch in Google Scholar

Mishra RK, Sin gh SK. Reversible antifertility eff ect of aqueous rhizome extract of Curcuma longa L. in male laboratory mice. Contraception 79, 479-487, 2009.10.1016/j.contraception.2009.01.00119442785Open DOISearch in Google Scholar

Mohanty I, Sin gh Arya D, Dinda A, Joshi S, Talwar KK, Gupta SK. Protective eff ects of Curcuma longa on ischemiareperfusion induced myocardial injuries and their mechanisms. Life Sci 75, 1701-1711, 2004.10.1016/j.lfs.2004.02.03215268970Open DOISearch in Google Scholar

Mohebbati R, S hafei MN, Soukhtanloo M, Mohammadian Roshan N, Khajavi Rad A, Anaeigoudari A, Hosseinian S, Karimi S, Beheshti F. Adriamycin-induced oxidative stress is prevented by mixed hydro-alcoholic extract of Nigella sativa and Curcuma longa in rat kidney. Avicenna J Phytomed 6, 86-94, 2016.Search in Google Scholar

Montopoli M, R agazzi E, Froldi G, Caparrotta L. Cell‐cycle inhibition and apoptosis induced by curcumin and cisplatin or oxaliplatin in human ovarian carcinoma cells. Cell Prolif 42, 195-206, 2009.10.1111/j.1365-2184.2009.00585.x649546219236381Search in Google Scholar

Moon C, Soria J- C, Jang SJ, Lee J, Obaidul Hoque M, Sibony M, Trink B, Chang YS, Sidransky D, Mao L. Involvement of aquaporins in colorectal carcinogenesis. Oncogene 22, 6699-6703, 2003.10.1038/sj.onc.120676214555983Open DOISearch in Google Scholar

Moussavi M, Assi K, Gomez-Munoz A, Salh B. Curcumin mediates ceramide generation via the de novo pathway in colon cancer cells. Carcinogenesis 27, 1636-1644, 2006.10.1093/carcin/bgi37116501251Open DOISearch in Google Scholar

Nagata D, Takeda R, Sata M, Satonaka H, Suzuki E, Nagano T, Hirata Y. AMP-activated protein kinase inhibits angiotensin II-stimulated vascular smooth muscle cell proliferation. Circulation 110, 444-451, 2004.10.1161/01.CIR.0000136025.96811.7615262850Search in Google Scholar

Naik RS, Mujumda r AM, Ghaskadbi S. Protection of liver cells from ethanol cytotoxicity by curcumin in liver slice culture in vitro. J Ethnopharmacol 95, 31-37, 2004.10.1016/j.jep.2004.06.03215374604Search in Google Scholar

Oguzturk H, Cift ci O, Aydin M, Timurkaan N, Beytur A, Yilmaz F. Ameliorative eff ects of curcumin against acute cadmium toxicity on male reproductive system in rats. Andrologia 44, 243-249, 2012.10.1111/j.1439-0272.2012.01273.x22257170Open DOISearch in Google Scholar

Pan W, Yang H, C ao C, Song X, Wallin B, Kivlin R, Lu S, Hu G, Di W, Wan Y. AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells. Oncol Rep 20, 1553-1559, 2008.Search in Google Scholar

Park MJ, Kim EH, Park IC, Lee HC, Woo SH, Lee JY, Hong YJ, Rhee CH, Choi SH, Shim BS, Lee SH, Hong SI. Curcumin inhibits cell cycle progression of immortalized human umbilical vein endothelial (ECV304) cells by up-regulating cyclin-dependent kinase inhibitor, p21WAF1/CIP1, p27KIP1 and p53. Int J Oncol 21, 379-384, 2002.10.3892/ijo.21.2.379Search in Google Scholar

Purohit A. Antif ertility effi cacy of Curcuma longa (50% E to H extract) with special referance to serum biochemistry and fertility test. Anc Sci Life 18, 192-194, 1999.Search in Google Scholar

Qureshi S, Shah A, Ageel A. Toxicity studies on Alpinia galanga and Curcuma longa. Planta Med 58, 124-127, 1992.10.1055/s-2006-9614121529022Open DOISearch in Google Scholar

Raj A, Singh A, Sharma A, Singh N, Kumar P, Bhatia V. Antifertility activity of medicinal plants on reproductive system of female rat. Int J Bio-Eng Sci Technol 2, 44-50, 2011.Search in Google Scholar

Sahoo DK, Roy A, Chainy GB. Protective eff ects of vitamin E and curcumin on L-thyroxine-induced rat testicular oxidative stress. Chem Biol Interac 176, 121-128, 2008.10.1016/j.cbi.2008.07.00918723006Search in Google Scholar

Sak ME, Soydinc HE, Sak S, Evsen MS, Alabalik U, Akdemir F, Gul T. Th e protective eff ect of curcumin on ischemiareperfusion injury in rat ovary. Int J Surg 11, 967-970, 2013.10.1016/j.ijsu.2013.06.00723796447Search in Google Scholar

Sharma RA, Gesch er AJ, Steward WP. Curcumin: the story so far. Eur J Cancer 41, 1955-1968, 2005. 10.1016/j.ejca.2005.05.00916081279Open DOISearch in Google Scholar

Sharma P, Singh R. Protective role of curcumin on lindane induced reproductive toxicity in male Wistar rats. Bull Environ Contam Toxicol 84, 378-384, 2010.10.1007/s00128-010-9942-y20182699Search in Google Scholar

Shi M, Cai Q, Ya o L, Mao Y, Ming Y, Ouyang G. Antiproliferation and apoptosis induced by curcumin in human ovarian cancer cells. Cell Biol Int 30, 221-226, 2006.10.1016/j.cellbi.2005.10.02416376585Open DOISearch in Google Scholar

Shukla PK, Khann a VK, Khan MY, Srimal RC. Protective eff ect of curcumin against lead neurotoxicity in rat. Hum Exp Toxicol 22, 653-658, 2003.10.1191/0960327103ht411oa14992327Open DOISearch in Google Scholar

Siddik ZH. Cispl atin: mode of cytotoxic action and molecular basis of resistance. Oncogene 22, 7265-7279, 2003.10.1038/sj.onc.120693314576837Open DOISearch in Google Scholar

Srivastava G, Me hta JL. Currying the heart: curcumin and cardioprotection. J J Cardiovasc Pharmacol Th er 14, 22-27, 2009.10.1177/107424840832960819153099Search in Google Scholar

Swamy MV, Citine ni B, Patlolla JMR, Mohammed A, Zhang Y, Rao CV. Prevention and treatment of pancreatic cancer by curcumin in combination with omega-3 fatty acids. Nutr Cancer 60, 81-89, 2008.10.1080/0163558080241670319003584Search in Google Scholar

Thakur S, Bawara B, Dubey A, Nandini D, Chauhan NS, Saraf DK. Eff ect of Carum carvi and Curcuma longa on hormonal and reproductive parameter of female rats. Int J Phytomed 1, 31-38, 2009.10.5138/ijpm.2009.0975.0185.05791Search in Google Scholar

Van Laere SJ, Va n der Auwera I, Van den Eynden GG, Elst HJ, Weyler J, Harris AL, van Dam P, Van Marck EA, Vermeulen PB, Dirix LY. Nuclear factor-KB signature of infl ammatory breast cancer by cDNA microarray validated by quantitative real-time reverse transcription-PCR, immunohistochemistry, and nuclear factor-KB DNA-binding. Clin Cancer Res 12, 3249-3256, 2006.10.1158/1078-0432.CCR-05-280016740744Open DOISearch in Google Scholar

Verkman A. More than just water channels: unexpected cellular roles of aquaporins. J Cell Sci 118, 3225-3232, 2005. 10.1242/jcs.0251916079275Open DOISearch in Google Scholar

Wahl H, Tan L, G riffi th K, Choi M, Liu JR. Curcumin enhances Apo2L/TRAIL-induced apoptosis in chemoresistant ovarian cancer cells. Gynecol Oncol 105, 104-112, 2007.10.1016/j.ygyno.2006.10.05017174384Open DOISearch in Google Scholar

Watson JL, Green shields A, Hill R, Hilchie A, Lee PW, Giacomantonio CA, Hoskin DW. Curcumin‐induced apoptosis in ovarian carcinoma cells is p53‐independent and involves p38 mitogen‐activated protein kinase activation and downregulation of Bcl‐2 and survivin expression and Akt signaling. Mol Carcinog 49, 13-24, 2010.10.1002/mc.20571Search in Google Scholar

Wilken R, Veena MS, W ang MB, Srivatsan ES. Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol Cancer 10, 12, 2011.10.1186/1476-4598-10-12Search in Google Scholar

Yamamoto Y, Gaynor RB . Th erapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer. J Clin Invest 107, 135-142, 2001.10.1172/JCI11914Search in Google Scholar

Yang Yl, Ji C, Cheng L, He L, Lu CC, Wang R, Bi ZG. Sphingosine kinase‐1 inhibition sensitizes curcumin‐induced growth inhibition and apoptosis in ovarian cancer cells. Cancer Sci 103, 1538-1545, 2012.10.1111/j.1349-7006.2012.02335.xSearch in Google Scholar

Yu J, Zhang L. Th e transcr iptional targets of p53 in apoptosis control. Biochem Biophys Res Commun 331, 851-858, 2005.10.1016/j.bbrc.2005.03.189Search in Google Scholar

Yu YY, Li Q, Zhu ZG. NF-ka ppaB as a molecular target in adjuvant therapy of gastrointestinal carcinomas. Eur J Surg Oncol 31, 386-392, 2005.10.1016/j.ejso.2004.10.010Open DOISearch in Google Scholar

Yu T, Li J, Qiu Y, Sun H. 1-Phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) facilitates curcumin-induced melanoma cell apoptosis by enhancing ceramide accumulation, JNK activation, and inhibiting PI3K/AKT activation. Mol Cell Biochem 361, 47-54, 2012.10.1007/s11010-011-1086-9Search in Google Scholar

Zhou C, Zhao XM, Li XF, Wan g C, Zhang XT, Liu XZ, Ding XF, Xiang SL, Zhang J. Curcumin inhibits AP-2γ- induced apoptosis in the human malignant testicular germ cells in vitro. Acta Pharmacol Sin 34, 1192-1200, 2013.10.1038/aps.2013.38Open DOISearch in Google Scholar

Zunino F, Perego P, Pilotti S , Pratesi G, Supino R, Arcamone F. Role of apoptotic response in cellular resistance to cytotoxic agents. Pharmacol Th er 76, 177-185, 1997.10.1016/S0163-7258(97)00086-7Search in Google Scholar