Evaluation of the Content of Free Amino Acids in Tobacco by a New Liquid Chromatography-Tandem Mass Spectrometry Technique

1. Weeks, W.W.: Relationship Between Leaf Chemistry and Organoleptic Properties of Tobacco Smoke; in: Tobacco, Production, Chemistry and Technology, edited by D.L. Davis and M.T. Nielsen, Blackwell Science, Oxford, UK, 1999.Search in Google Scholar

2. Collins, P.F., N.M. Sarji, and J.F. Williams: An Automated Procedure for the Determination of Total Amino Acids and its Application to the Analysis of Tobacco; Beitr. Tabakforsch.. 7 (1974) 228-234.Search in Google Scholar

3. Peng, L., M. Wu, and J. Xie: Changes in Levels of Amino Acids and Basic Components in Burley Tobacco Produced by Roasting; Beitr. Tabakforsch. Int. 20 (2003) 459-466.Search in Google Scholar

4. Préfontaine, D., A. Morin, C. Jumarie, and A. Porter: In Vitro Bioactivity of Combustion Products From 12 Tobacco Constituents; Food Chem. Toxicol. 44 (2006) 724-738.Search in Google Scholar

5. Mizusaki, S., H. Okamoto, A. Akiyama, and Y. Fukuhara: Relation Between Chemical Constituents of Tobacco and Mutagenic Activity of Cigarette Smoke Condensate; Mutat. Res. 48 (1977) 319-325.Search in Google Scholar

6. Moldoveanu, S.C.: Pyrolysis of Organic Molecules with Applications to Health and Environmental Issues; Elsevier, Amsterdam, The Netherlands, 2010.Search in Google Scholar

7. Moldoveanu, S.C. and A.R. Gerardi: Acrylamide Analysis in Tobacco, Alternative Tobacco Products, and Cigarette Smoke; J. Chromatogr. Sci. 49 (2011) 234-242.Search in Google Scholar

8. Amrein, T.M.: Systematic Studies on Process Optimization to Minimize Acrylamide Contents in Food; Diss. ETH Nr. 16311, Zurich, Switzerland, 2005.Search in Google Scholar

9. Carugno, N., M. Neri, and G. Lionetti: Quantitative Determination of Free and Protein-Bound Amino Acids of Tobacco; Beitr. Tabakforsch. 7 (1974) 222-227.Search in Google Scholar

10. Zhu, X.-L., Q.-S. Zhu, and Y. Gao: Fast Analysis of Free Amino Acids in Tobacco by HPLC with Fluorescence Detection and Automated Derivatization; J. Chin. Chem. Soc. 55 (2008) 1094-1100.Search in Google Scholar

11. Henderson, J.W., R.D. Ricker, B.A. Bidlingmeyer, and C. Woodward: Rapid, Accurate, Sensitive, and Reproducible HPLC Analysis of Amino Acids; Agilent Technologies, USA, Part No. 5980-1193E.Search in Google Scholar

12. Özcan, S. and H. Z. Senyuva: Improved and Simplified Liquid Chromatography / Atmospheric Pressure Chemical Ionization Mass Spectrometry Method for the Analysis of Underivatized Free Amino Acids in Various Foods; J. Chromatogr. A 1135 (2006) 179-185.Search in Google Scholar

13. Moldoveanu, S.C.: Analysis of Protein Amino Acids in Tobacco Using Microwave Digestion of Plant Material; Beitr. Tabakforsch. Int. 21 (2005) 451-465.Search in Google Scholar

14. Henderson Jr, J.W. and A. Brooks: Improved Amino Acid Methods Using Agilent ZORBAX Eclipse Plus C18 Columns for A Variety of Agilent LC Instrumentation and Separation Goals; Agilent Technologies, USA, Part No. 5990-4547EN.Search in Google Scholar

15. Woodward, C., J.W. Henderson, and T. Wielgos: Highspeed Amino Acid Analysis (AAA) on 1.8 μM Reversed-phase (RP) Columns; Agilent Technologies, USA, Part No. 5989-6297EN, 2007.Search in Google Scholar

16. Gritti, F.: Quantification of Individual Mass Transfer Phenomena in Liquid Chromatography for Further Improvement of Column Efficiency; LC/GC North America, 32 (2014) 928-940.Search in Google Scholar

17. Gritti, F. and G. Guiochon: Comparison Between the Intra-Particle Diffusivity in the Hydrophilic Interaction Chromatography and Reversed Phase Liquid Chromatography Modes. Impact on the Column Efficiency; J. Chromatogr. A 1297 (2013) 85-95.Search in Google Scholar

18. Moldoveanu, S. and V. David: Modern Sample Preparation for Chromatography; Elsevier, Amsterdam, The Netherlands, 2014.10.1016/B978-0-444-54319-6.00002-5Search in Google Scholar

19. Moldoveanu, S.C. and V. David: Essentials in Modern HPLC Separations, Elsevier, Amsterdam, The Netherlands, 2013.Search in Google Scholar

20. Leffingwell, J.C.: Leaf Chemistry; in: Tobacco: Production, Chemistry and Technology, edited by D.L. Davis and M.T. Nielsen, Blackwell Science, Oxford, UK, 1999, pp.265-312.Search in Google Scholar

21. Elliott, P.E., D.M. Lawson, and S.C. Moldoveanu: Tobacco Having Reduced Amounts of Amino Acids and Methods for Producing Such Lines; Patent application number: 20130068240, Publication date: 2013-03-21. Search in Google Scholar