<abstract xmlns="http://www.w3.org/1999/xhtml">

<p> Macrophages and cytokines are important in the control of inflammation and regulation of the immune response. However, they can also contribute to immunopathology in the host after viral infection and the regulatory network can be subverted by infectious agents, including viruses, some of which produce cytokine analogues or have mechanisms that inhibit cytokine function. African swine fever virus (ASFV) encodes a number of proteins which modulate cytokine and chemokine induction, host transcription factor activation, stress responses, and apoptosis. The aim of this review is to elucidate the mechanisms of immune responses to ASFV in different subpopulations of porcine macrophages. A transcriptional immune response in different resident tissue macrophages following ASFV infection was presented in many publications. ASFV-susceptible porcine macrophages can be of several origins, such as peripheral blood, lungs, bone marrow, etc. blood monocytes, blood macrophages, and lung macrophages have demonstrated a modulation of phenotype. Monocyte-derived macrophages could express surface markers not found on their monocyte precursors. Moreover, they can undergo further differentiation after infection and during inflammation. When viruses infect such cells, immunological activity can be seriously impaired or modified.</p>
</abstract>

Macrophages and cytokines are important in the control of inflammation and regulation of the immune response. However, they can also contribute to immunopathology in the host after viral infection and the regulatory network can be subverted by infectious agents, including viruses, some of which produce cytokine analogues or have mechanisms that inhibit cytokine function. African swine fever virus (ASFV) encodes a number of proteins which modulate cytokine and chemokine induction, host transcription factor activation, stress responses, and apoptosis. The aim of this review is to elucidate the mechanisms of immune responses to ASFV in different subpopulations of porcine macrophages. A transcriptional immune response in different resident tissue macrophages following ASFV infection was presented in many publications. ASFV-susceptible porcine macrophages can be of several origins, such as peripheral blood, lungs, bone marrow, etc. blood monocytes, blood macrophages, and lung macrophages have demonstrated a modulation of phenotype. Monocyte-derived macrophages could express surface markers not found on their monocyte precursors. Moreover, they can undergo further differentiation after infection and during inflammation. When viruses infect such cells, immunological activity can be seriously impaired or modified.

Transcriptional immunoresponse of tissue-specific macrophages in swine after infection with African swine fever virus

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Macrophages and cytokines are important in the control of inflammation and regulation of the immune response. However, they can also contribute to...

Transcriptional immunoresponse of tissue-specific macrophages in swine after infection with African swine fever virus

Pubblicato online: 30 dic 2015

Pagine: 441 - 446

Ricevuto: 04 ago 2015

Accettato: 04 dic 2015

DOI: https://doi.org/10.1515/bvip-2015-0064

Parole chiave
African swine fever virus, immunology, macrophages, monocytes

© National Veterinary Research Institute in Pulawy

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Transcriptional immunoresponse of tissue-specific macrophages in swine after infection with African swine fever virus

Pubblicato online: 30 dic 2015

Pagine: 441 - 446

Ricevuto: 04 ago 2015

Accettato: 04 dic 2015

DOI: https://doi.org/10.1515/bvip-2015-0064

Parole chiaveAfrican swine fever virus, immunology, macrophages, monocytes

© National Veterinary Research Institute in Pulawy

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Parole chiave
African swine fever virus, immunology, macrophages, monocytes