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<p>The aim of the study was to determine total antioxidative capacity (TAC) and zinc concentration in serum of dogs suffering from perianal tumours just before the start of the antihormonal treatment (AHT) and one and six months later. The study was performed on 45 dogs divided into two groups: control group suffering from non-malignant tumours (N = 24) and a group with malignant neoplastic changes (N = 21). Serum TAC and zinc concentrations were measured using photometric and atomic absorption spectrophotometric methods. Six months after the start of the AHT, TAC was significantly lower by 10.6% in dogs with malignant tumours when compared to controls (P = 0.03). In the non-malignant group, serum zinc concentration was higher before the treatment than in the malignant group, while the opposite results were observed six months later (P &lt; 0.001). In the non-malignant group, gradually decreasing values of serum zinc concentration at each stage of the investigation were observed, while the opposite results were obtained in the malignant group (P &lt; 0.05). The obtained results indicate that malignant neoplastic process is associated with significantly reduced TAC. Determination of serum zinc concentration in dogs with non-malignant and malignant perianal tumours may have practical diagnostic and prognostic values and may serve towards increasing the effectiveness of AHT monitoring.</p>
</abstract>

The aim of the study was to determine total antioxidative capacity (TAC) and zinc concentration in serum of dogs suffering from perianal tumours just before the start of the antihormonal treatment (AHT) and one and six months later. The study was performed on 45 dogs divided into two groups: control group suffering from non-malignant tumours (N = 24) and a group with malignant neoplastic changes (N = 21). Serum TAC and zinc concentrations were measured using photometric and atomic absorption spectrophotometric methods. Six months after the start of the AHT, TAC was significantly lower by 10.6% in dogs with malignant tumours when compared to controls (P = 0.03). In the non-malignant group, serum zinc concentration was higher before the treatment than in the malignant group, while the opposite results were observed six months later (P < 0.001). In the non-malignant group, gradually decreasing values of serum zinc concentration at each stage of the investigation were observed, while the opposite results were obtained in the malignant group (P < 0.05). The obtained results indicate that malignant neoplastic process is associated with significantly reduced TAC. Determination of serum zinc concentration in dogs with non-malignant and malignant perianal tumours may have practical diagnostic and prognostic values and may serve towards increasing the effectiveness of AHT monitoring.

Total antioxidative capacity and zinc concentration in dogs suffering from perianal tumours

Department and Clinic of Animal Surgery, Faculty of Veterinary Medicine

Department of Andrology and Biotechnology of Reproduction, Faculty of Veterinary Medicine

Department of Animal Physiology, Faculty of Veterinary Medicine

Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The aim of the study was to determine total antioxidative capacity (TAC) and zinc concentration in serum of dogs suffering from perianal tumours just before...

Total antioxidative capacity and zinc concentration in dogs suffering from perianal tumours

Pubblicato online: 30 set 2015

Pagine: 417 - 423

Ricevuto: 14 giu 2015

Accettato: 04 set 2015

DOI: https://doi.org/10.1515/bvip-2015-0061

Parole chiave
dog, perianal gland tumours, zinc, oxidative stress, total antioxidative capacity

© 2015 National Veterinary Research Institute in Pulawy

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Total antioxidative capacity and zinc concentration in dogs suffering from perianal tumours

Pubblicato online: 30 set 2015

Pagine: 417 - 423

Ricevuto: 14 giu 2015

Accettato: 04 set 2015

DOI: https://doi.org/10.1515/bvip-2015-0061

Parole chiavedog, perianal gland tumours, zinc, oxidative stress, total antioxidative capacity

© 2015 National Veterinary Research Institute in Pulawy

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Parole chiave
dog, perianal gland tumours, zinc, oxidative stress, total antioxidative capacity