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<p>Fenpropathrin (FEN) was administered intraperitoneally in doses of 2.38 mg/kg, 5.9 5mg/kg, or 11.9 mg/kg b.w. to mice for 28 consecutive days. FEN did not significantly affect the activity of alanine transaminase (ALT) in the sera. Superoxide dismutase and glutathione peroxidase activities were significantly elevated in the liver after a 28-d exposure to moderate or highest doses of the pesticide. These results demonstrate that the 28-day exposure to FEN leads to an up-regulation of expression of antioxidant enzymes in response to an oxidative stress in mouse liver without causing a significant increase in ALT activity.</p>
</abstract>

Fenpropathrin (FEN) was administered intraperitoneally in doses of 2.38 mg/kg, 5.9 5mg/kg, or 11.9 mg/kg b.w. to mice for 28 consecutive days. FEN did not significantly affect the activity of alanine transaminase (ALT) in the sera. Superoxide dismutase and glutathione peroxidase activities were significantly elevated in the liver after a 28-d exposure to moderate or highest doses of the pesticide. These results demonstrate that the 28-day exposure to FEN leads to an up-regulation of expression of antioxidant enzymes in response to an oxidative stress in mouse liver without causing a significant increase in ALT activity.

Effect of 28-Day Exposure to Fenpropathrin on the Activities of Serum Alanine Transaminase and Liver Antioxidant Enzymes in Mice

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fenpropathrin (FEN) was administered intraperitoneally in doses of 2.38 mg/kg, 5.9 5mg/kg, or 11.9 mg/kg b.w. to mice for 28 consecutive days. FEN did not...

Effect of 28-Day Exposure to Fenpropathrin on the Activities of Serum Alanine Transaminase and Liver Antioxidant Enzymes in Mice

Pubblicato online: 01 apr 2015

Pagine: 165 - 169

Ricevuto: 30 ott 2014

Accettato: 03 mar 2015

DOI: https://doi.org/10.1515/bvip-2015-0025

© 2015 National Veterinary Research Institute in Pulawy

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.