<abstract xmlns="http://www.w3.org/1999/xhtml"><p>This study investigates the anti-diabetic effects of rutin from tartary buckwheat sprout in type 2 diabetes mouse model. The rutin content in tartary buckwheat sprout (TBS) is five times higher than that found in common buckwheat sprout (CBS) as evident from high-performance liquid chromatography analysis. Administration of either rutin or TBS ethanolic extract to diabetes mice decreased the serum glucose level significantly. Rutin down-regulated the expression levels of protein-tyrosine phosphatase 1B; it is negative regulator of insulin pathway, both transcriptionally and translationally in myocyte C2C12 in a dose-dependent manner. In conclusion, rutin can play a critical role in down-regulation of serum glucose level in type 2 diabetes.</p></abstract>

This study investigates the anti-diabetic effects of rutin from tartary buckwheat sprout in type 2 diabetes mouse model. The rutin content in tartary buckwheat sprout (TBS) is five times higher than that found in common buckwheat sprout (CBS) as evident from high-performance liquid chromatography analysis. Administration of either rutin or TBS ethanolic extract to diabetes mice decreased the serum glucose level significantly. Rutin down-regulated the expression levels of protein-tyrosine phosphatase 1B; it is negative regulator of insulin pathway, both transcriptionally and translationally in myocyte C2C12 in a dose-dependent manner. In conclusion, rutin can play a critical role in down-regulation of serum glucose level in type 2 diabetes.

Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes

Biological Disaster Analysis Group, Korea Basic Science Institute, Daejeon 34133, Republic of Korea

Drug & Disease Target Group, Korea Basic Science Institute, Daejeon 34133, Republic of Korea

Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon 34134, Republic of Korea

National Agricultural Research Center for Hokkaido Region, Memuro, Hokkaido 0820081, Japan

Department of Agricultural Chemistry, Chungbuk National University, Cheongju 28644, Republic of Korea

Department of Crop Science, Chungbuk National University, Cheongju 28644, Republic of Korea

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

This study investigates the anti-diabetic effects of rutin from tartary buckwheat sprout in type 2 diabetes mouse model. The rutin content in tartary buckwheat...

Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes

Pubblicato online: 28 mag 2016

Pagine: 297 - 302

Accettato: 11 gen 2016

DOI: https://doi.org/10.1515/acph-2016-0021

Parole chiave
tartary buckwheat sprout, rutin, type 2 diabetes, insulin signaling

© 2016 Dong-Gi Lee et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes

Pubblicato online: 28 mag 2016

Pagine: 297 - 302

Accettato: 11 gen 2016

DOI: https://doi.org/10.1515/acph-2016-0021

Parole chiavetartary buckwheat sprout, rutin, type 2 diabetes, insulin signaling

© 2016 Dong-Gi Lee et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Parole chiave
tartary buckwheat sprout, rutin, type 2 diabetes, insulin signaling