[1. A. Lacy and R. O’Kennedy, Studies on coumarins and coumarin-related compounds to determine their therapeutic role in the treatment of cancer, Cur. Pharm. Des. 10 (2004) 3797-3811; DOI: 10.2174/1381612043382693.10.2174/1381612043382693]Search in Google Scholar
[2. M. E. Marshall, M. Ryles, K. Butler and L. Weiss, Treatment of advanced renal cell carcinoma (RCC) with coumarin and cimetidine: longterm follow-up of patients treated on a phase I trial, J. Cancer Res. Clin. Oncol. 120 (1994) 535-538.]Search in Google Scholar
[3. U. S. Weber, B. Steff en and C. P. Siegers, Antitumour-activities of coumarin, 7-hydroxycoumarin and its glucuronide in several human tumour cell lines, Res. Commun. Mol. Pathol. Pharmacol. 99 (1998) 193-206.]Search in Google Scholar
[4. M. A. Velasco-Velazquez, J. Agramonte-Hevia, D. Barrera, A. Jimenez-Orozco, M. J. Garcia-Mondragon, N. Mendoza-Patino, A. Landa and J. Mandoki, 4-Hydroxycoumarin disorganizes the actin cytoskeleton in B16-F10 melanoma cells but not in B82 fibroblasts, decreasing their adhesion to extracellular matrix proteins and motility, Cancer Le_ . 198 (2003) 179-186; DOI: 10.1016/S0304-3835(03)00333-1.10.1016/S0304-3835(03)00333-1]Search in Google Scholar
[5. S. Stanchev, G. Momekov, F. Jensen and I. Manolov, Synthesis, computational study and cytotoxic activity of new 4-hydroxycoumarin derivatives, Eur. J. Med. Chem. 43 (2008) 694-706; DOI: 10.1016/j.ejmech.2007.05.005.10.1016/j.ejmech.2007.05.005]Search in Google Scholar
[6. J. L. Mohler, L. G. Gomella, E. D. Crawford, L. M. Glode, C. D. Zippe, W. R. Fair and M. E. Marshall, Phase II evaluation of coumarin (1,2-benzopyrone) in metastatic prostatic carcinoma, Prostate 20 (1992) 123-131.10.1002/pros.2990200208]Search in Google Scholar
[7. F. H. Dexeus, C. J. Logothetis, A. Sella, K. Fitz, R. Amato, J. M. Reuben and N. Dozier, Phase II study of coumarin and cimetidine in patients with metastatic renal-cell carcinoma, J. Clin. Oncol. 8 (1990) 325-329.10.1200/JCO.1990.8.2.325]Search in Google Scholar
[8. D. Cooke, Studies on the Mode of Action of Coumarins (Coumarin, 6-Hydroxycoumarin, 7-Hydroxycoumarin and Esculetin) at a Cellular Level, Ph. D. Thesis, Dublin City University, Dublin, 1999; h_ p:// doras.dcu.ie/18438/1/Deirdre_A_Cooke.pdf; last access date March 10, 2014.]Search in Google Scholar
[9. F. Jimenez-Orozco, J. S. Lopez-Gonzalez, A. Nieto-Rodriguez, M. A. Velasco-Velazquez, J. A. Molina- Guarneros, N. Mendoza-Patino, M. J. Garica-Mondragon, P. Elizalde-Galvan, F. Leon-Cedeno and J. J. Mandoki, Decrease of cyclin D1 in the human lung adenocarcinoma cell line A-427 by 7-hydroxycoumarin, Lung Cancer 34 (2001) 185-194.10.1016/S0169-5002(01)00263-X]Search in Google Scholar
[10. M. A. Musa, J. S. Cooperwood and M. O. F. Khan, A review of cumarin derivatives in pharmacotherapy of breast cancer, Cur. Med. Chem. 15 (2008) 2664-2679; DOI: 10.2174/092986708786242877.10.2174/092986708786242877377264418991629]Search in Google Scholar
[11. H. A. Assi, K. E. Khoury, H. Dbouk, L. E. Khalil, T. H. Mouhieddine and N. S. El Saghir, Epidemiology and prognosis of breast cancer in young women, J. Thorac. Dis. 5 (2013) S2-S8; DOI: 10.3978/j. issn.2072-1439.2013.05.24.]Search in Google Scholar
[12. Y-H. Hsiao, M-C. Chou, C. Flower, J. T. Mason and Y-G. Man, Breast cancer heterogeneity: mechanisms, proofs, and implications, J. Cancer 1 (2010) 6-13; DOI: 10.7150/jca.1.6.10.7150/jca.1.6293135420842218]Search in Google Scholar
[13. Y. G. Man and H. E. Nieburgs, A subset of cell clusters with malignant features in morphologically normal and hyperplastic breast tissues, Cancer Detect. Prev. 30 (2006) 239-247; DOI: 10.1016/j. cdp.2006.04.006.]Search in Google Scholar
[14. P. Clezardin, Therapeutic targets for bone metastases in breast cancer, Breast Cancer Res. 13 (2011) 207-215; DOI: 10.1186/bcr2835.10.1186/bcr2835321918121586099]Search in Google Scholar
[15. M. C. Ravnan, S. L. Ravnan and M. P. Walberg, Metastatic breast cancer: a review of current and novel pharmacotherapy, Formulary 46 (2011) 130-146.]Search in Google Scholar
[16. F. Cardoso, E. Senkus-Kone_ a, L. Fallowfi eld, A. Costa and M. Castigilone, Locally recurrent or metastatic breast cancer: ESMO Clinical practice guidelines for diagnosis, treatment and followup, Ann. Oncol. 21 (2010) v15-v19; DOI: 10.1093/annonc/mdq160.10.1093/annonc/mdq16020555067]Search in Google Scholar
[17. O. Pagani, E. Senkus, W. Wood, M. Colleoni, T. Cufer, S. Kyriakides, A. Costa, E. P. Winer and F. Cardoso, International guidelines for management of metastatic breast cancer: can metastatic breast cancer be cured? J. Natl. Cancer Inst. 102 (2010) 456-463; DOI: 10.1093/jnci/djq029.18.]Search in Google Scholar
[18. A. Jashari, F. Imeri, L. Ballazhi, A. Shabani, B. Mikhova, G. Drager, E. Popovski and A. Huwiler, Synthesis and cellular characterization of novel isoxazolo- and thiazolohydrazinyldiene-chroman-2,4-diones on cancer and non-cancer cell growth and death, Bioorg. Med. Chem. 22 (2014) 2655-2661; DOI: 10.1016/j.bmc.2014.03.026.19.K.]Search in Google Scholar
[19. K. Tabakovic, I. Tabakovic, M. Trkovnik and N. Trinajstic, Chemistry of coumarins. Nucleophilic substitutions of 4-chloro-3-nitrocoumarin with hard and so_ nucleophiles, Liebigs Ann. Chem. 11 (1983) 1901-1909; DOI: 10.1002/jlac.198319831105.10.1002/jlac.198319831105]Search in Google Scholar
[20. M. M. Ramla, M. A. Omar, A. M. M. El-Khamry and H. L. El-Diwan, Synthesis and antitumour activity of 1-substituted-2-methyl-5-nitrobenzimidazoles, Bioorg. Med. Chem. 14 (2006) 7324-7332; DOI: 10.1016/j.bmc.2006.06.033.10.1016/j.bmc.2006.06.033]Search in Google Scholar
[21. E. Gulsory and N. U. Guzeldemirci, Synthesis and primary cytotoxicity evaluation of new imidazo[ 2,1-b]thiazole derivatives, Eur. J. Med. Chem. 42 (2007) 320-326; DOI: 10.1016/j.ejmech. 2006.10.012.]Search in Google Scholar
[22. M. J. Choi, E. S. No, D. A. Thorat, J. W. Jang, H. Yang, J. Lee, H. Choo, S. J. Kim, C. S. Lee, S. Y. Ko, J. Lee, G. Nam and A. N. Pae, Synthesis and biological evaluation of aryloxazole derivatives as antimitotic and vascular-disrupting agents for cancer therapy, J. Med. Chem. 56 (2013) 9008-9018; DOI: 10.1021/jm400840p.10.1021/jm400840p]Search in Google Scholar
[23. P. Poma, M. Notarbartolo, M. Labbozze_ a, A. Maurici, V. Carina, Alaimo, M. Rizzi, D. Simoni and N. D’Alessandro, The antitumour activities of curcumin and of its isoxazole analogue are not affected by multiple gene expression changes in an MDR model of the MCF-7 breast cancer cell line: analysis of the possible molecular basis, Int. J. Mol. Med. 20 (2007) 329-335; DOI: 10.3892/ ij mm.20.3.329.]Search in Google Scholar
[24. M. S. Al-Said, M. S. Bashandy, S. I. Al-qasoumi and M. M. Ghorab, Anti-breast cancer activity of some novel 1,2-dihydropyridine, thiophene and thiazole derivatives, Eur. J. Med. Chem. 46 (2011) 137-141; DOI: 10.1016/j.ejmech.2010.10.024. 10.1016/j.ejmech.2010.10.024]Search in Google Scholar
[25. M. I. Soares, A. F. Brito, M. Laranjo, A. M. Abrantes, M. F. Botelho, J. A. Paixao, A. M. Beja, M. R. Silva, E. Pinho and T. M. Melo, Chiral 6-hydroxymethyl-1H,3H-pyrrolo[1,2-c]thiazoles: novel antitumour DNA monoalkylating agents, Eur. J. Med. Chem. 45 (2010) 4676-4681; DOI: 10.1016/j.ejmech. 2010.07.029.]Search in Google Scholar
[26. P. Chene, C. Garcia-Echeverria, M. R. Jensen, C. Quadt, T. Radimerski and J. Schoepfer, Isoxasole compound for the treatment of cancer, Patent WO 2009047323 A2, 16 April 2009.]Search in Google Scholar
[27. Y. Kang, P. M. Siegel, W. Shu, M. Drobnjak, S. M. Kakonen, C. Cordon-Cardo, T. A. Guise and J. Massague, A multigenic program mediating breast cancer metastasis to bone, Cancer Cell 3 (2003) 537-549; DOI: 10.1016/S1535-6108(03)00132-6.10.1016/S1535-6108(03)00132-6]Search in Google Scholar
[28. A. J. Minn, G. P. Gupta, P. M. Siegel, P. D. Bos, W. P. Shu, D. D. Giri, A. Viale, A. B. Olshen, W. L. Gerald and J. Massague, Genes that mediate breast cancer metastasis to lung, Nature 436 (2005) 518-524; DOI: 10.1038/nature03799.29.]Search in Google Scholar
[29. A. Jashari, E. Hey-Hawkins, B. Mikhova, G. Draeger and E. Popovski, An improved synthesis of 4-chlorocoumarin-3-sulfonyl chloride and its reactions with diff erent bidentae nucleophiles to give pyrido[1’,2’:2,3]- and thiazino[3’,2’:2,3]-1,2,4-thiadiazino[6,5-c]Benzopyran-6-one 7,7-dioxides, Molecules 12 (2007) 2017-2028; DOI: 10.3390/12082017.10.3390/12082017614911117960102]Search in Google Scholar
[30. A. Jashari, E. Popovski, B. Mikhova, R. P. Nikolova and B. L. Shivachev, 3-[2-(5-tert-butyl-1,2-oxazol-3-yl)hydrazinylidene] chroman-2,4-dione, Acta Crystalogr. E 69 (2013) o258; DOI: 10.1107/ S1600536813000858. ]Search in Google Scholar