Single nucleotide polymorphism (SNP) G–152A (rs11568020) in the promoter of the angiotensinogen gene (
To determine the frequency of SNP G–152A in Indonesian patients with hypertension and the function of this SNP.
We determined the frequency of the SNP in 100 patients by direct sequencing, and the influence of SNP G–152A on predicted binding of HIF-1 to the HRE using a docking approach in silico.
The
SNP G–152A reduces the favorability of binding of HIF-1 to the HRE. The occurrence of this SNP in the