<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_abm-2018-0018_s_003_w2aab3b7b5b1b6b1aab1c16b1Aa"><h3>Background</h3><p>Anemia is a common problem among patients with malaria infection, which induces hemolysis during treatment. A few patients present with autoimmune hemolytic anemia (AIHA) and autoantibodies, such as autoanti-E and autoanti-I, during malaria infection.</p></sec><sec id="j_abm-2018-0018_s_004_w2aab3b7b5b1b6b1aab1c16b2Aa"><h3>Objective</h3><p>To report the clinical response of a patient with <italic>Plasmodium falciparum</italic> malaria infection with a hemolytic condition.</p></sec><sec id="j_abm-2018-0018_s_005_w2aab3b7b5b1b6b1aab1c16b3Aa"><h3>Methods</h3><p>We reviewed medical records of a patient with <italic>P. falciparum</italic> malaria and related literature.</p></sec><sec id="j_abm-2018-0018_s_006_w2aab3b7b5b1b6b1aab1c16b4Aa"><h3>Results</h3><p>Our patient presented with <italic>P. falciparum</italic> malaria infection and received artesunate and ceftriaxone to cover potential tropical infectious diseases. After malaria parasite was eradicated, her hemoglobin declined, and AIHA and autoantibodies were found, explaining the cause of anemia. Corticosteroid was given at a standard dosage, and her hemoglobin became normal within 1 week.</p></sec><sec id="j_abm-2018-0018_s_007_w2aab3b7b5b1b6b1aab1c16b5Aa"><h3>Conclusion</h3><p>Patients with falciparum malaria and both AIHA and autoantibody complications are rare. Our patient responded to malaria eradication and corticosteroid treatment. Most cases reported seem to respond to corticosteroid with a variety of recovery times. However, corticosteroids might increase the severity of infection; more clinical data to support a standard regimen to treat properly rare hematologic complications (AIHA and autoantibodies) in malaria patients are warranted.</p></sec></abstract>

BackgroundAnemia is a common problem among patients with malaria infection, which induces hemolysis during treatment. A few patients present with autoimmune hemolytic anemia (AIHA) and autoantibodies, such as autoanti-E and autoanti-I, during malaria infection.ObjectiveTo report the clinical response of a patient with Plasmodium falciparum malaria infection with a hemolytic condition.MethodsWe reviewed medical records of a patient with P. falciparum malaria and related literature.ResultsOur patient presented with P. falciparum malaria infection and received artesunate and ceftriaxone to cover potential tropical infectious diseases. After malaria parasite was eradicated, her hemoglobin declined, and AIHA and autoantibodies were found, explaining the cause of anemia. Corticosteroid was given at a standard dosage, and her hemoglobin became normal within 1 week.ConclusionPatients with falciparum malaria and both AIHA and autoantibody complications are rare. Our patient responded to malaria eradication and corticosteroid treatment. Most cases reported seem to respond to corticosteroid with a variety of recovery times. However, corticosteroids might increase the severity of infection; more clinical data to support a standard regimen to treat properly rare hematologic complications (AIHA and autoantibodies) in malaria patients are warranted.

Autoimmune hemolytic anemia and autoantibodies in a patient with <italic>Plasmodium falciparum</italic> infection: report of a rare case and review of the literature

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Autoimmune hemolytic anemia and autoantibodies in a patient with  infection: report of a rare case and review of the literature

BackgroundAnemia is a common problem among patients with malaria infection, which induces hemolysis during treatment. A few patients present with autoimmune...

Autoimmune hemolytic anemia and autoantibodies in a patient with Plasmodium falciparum infection: report of a rare case and review of the literature

Article Category: Clinical report

Pubblicato online: 10 ott 2018

Pagine: 427 - 432

DOI: https://doi.org/10.1515/abm-2018-0018

Parole chiave
autoimmune hemolytic anemia, autoanti-E, autoanti-I, malaria, steroid

© 2017 Supat Chamnanchanunt et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Autoimmune hemolytic anemia and autoantibodies in a patient with Plasmodium falciparum infection: report of a rare case and review of the literature

Article Category: Clinical report

Pubblicato online: 10 ott 2018

Pagine: 427 - 432

DOI: https://doi.org/10.1515/abm-2018-0018

Parole chiaveautoimmune hemolytic anemia, autoanti-E, autoanti-I, malaria, steroid

© 2017 Supat Chamnanchanunt et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Parole chiave
autoimmune hemolytic anemia, autoanti-E, autoanti-I, malaria, steroid