Exploring the association between glucose-6-phosphate dehydrogenase deficiency and color blindness in Southeast Asia
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21 mar 2018
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Categoria dell'articolo: Brief communication
Pubblicato online: 21 mar 2018
Pagine: 365 - 370
DOI: https://doi.org/10.1515/abm-2018-0009
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© 2017 Ingfar Soontarawirat, Mallika Imwong, Charles J. Woodrow, Chalisa Louicharoen Cheepsunthorn, Nicholas P.J. Day, Richard Paul, Pratap Singhasivanon
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.
Figure 1
![Extent of homozygosity flanking the G6PD487A (Mahidol) allele over a 2.4-Mb region (based on Louicharoen et al. [7]). Positions of the 30 genotyped SNPs used to assess homozygosity are tagged by red arrows, and the positions of the Mahidol variant SNP and the SNP within the opsin locus are shown with orange arrows](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647066e583f1392090d68c63/j_abm-2018-0009_fig_001.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Credential=AKIA6AP2G7AKOUXAVR44%2F20250919%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Date=20250919T151244Z&X-Amz-Expires=3600&X-Amz-Signature=2b061fdf3c4cbd0bcabb641727bc4301dd3dada7d4be310caf4875b2dc80ad15&X-Amz-SignedHeaders=host&x-amz-checksum-mode=ENABLED&x-id=GetObject)
Distribution of 186 male participants in terms of color blindness and G6PD deficiency genotype
| G6PD deficient (n = 37) | G6PD normal (n = 149) | |
|---|---|---|
| Normal color vision | 36 (97.3%) | 139 (93.3%) |
| (34 Mahidol, 2 Viengchan) | ||
| Red-green color blind | 1 (2.7%) | 9 (6.0%) |
| (Mahidol) | ||
| Total color blindness | 0 (0%) | 1 (0.7%) |
Haplotypes for 60 male participants G6PD Mahidol487G
| rs1573656 (G<A) | N | ||
|---|---|---|---|
| Normal color vision | G | G | 20 |
| G | A | 22 | |
| A | G | 14 | |
| Red–green color blind | G | G | 3 |
| Total color blindness | G | A | 1 |