<abstract xmlns="http://www.w3.org/1999/xhtml"> Objectives: Quantitative values of cardiac iodine-123 metaiodobenzylguanidine (123I-MIBG) global and regional adrenergic innervation showed promising results in predicting clinical course of heart failure. Nevertheless data is lacking how global and regional cardiac 123I-MIBG imaging parameters correlate with patient’s clinical data and conventional heart failure markers. <bold>Patients and methods</bold>: Eighty-six patientswith class II-IVNewYorkHeartAssociation (NYHA) heart failure were investigated. Patients underwent early and late cardiac 123I-MIBG planar and single photon emission computed tomography (SPECT) scanning. Global and regional cardiac 123I-MIBG scores were calculated and compared to conventional heart failure markers (left ventricular ejection fraction (LVEF), B-type natriuretic peptide (BNP) and maximum rate of oxygen consumption (VO2 max)), followed by NYHA functional class clinical assessment at the time of investigation. <bold>Results</bold>: Weak statistically significant correlation was noted between LVEF and global and regional cardiac adrenergic denervation scores, between BNP and VO2 max and global cardiac adrenergic denervation scores. Global and regional cardiac adrenergic denervation scores significantly differed within LVEF ranges. Global cardiac adrenergic denervation scores significantly differed within BNP levels and NYHA functional class. <bold>Conclusions</bold>: Conventional cardiac heart failure markers had weak correlation with global and regional cardiac 123I-MIBG imaging parameters. Cardiac 123I-MIBG imaging markers differed significantly depending on LVEF and BNP levels, and NYHA functional class.</abstract>

Vilnius University, Faculty of Medicine, Vilnius, Lithuania

Centre of Radiology and Nuclear Medicine, Vilnius University Hospital Santariškių Klinikos, Vilnius, Lithuania

Centre of Cardiology and Angiology, Vilnius University Hospital Santariškių Klinikos, Vilnius, Lithuania

Correlation of cardiac 123I-MIBG imaging with conventional markers of the heart failure

<abstract xmlns="http://www.w3.org/1999/xhtml"> Aim. The aims of the study were to evaluate prevalence of silent cerebral infarctions (SCI) and determine their clinical and echocardiographic predictors in patients with atrial fibrillation (AF). <bold>Patients and methods. </bold>In prospective cross sectional study we examined 134 patients with non-valvular AF. Clinical examination, laboratory tests, transoesophageal, transthoracic echocardiography and multislice computed tomography of the brain were performed for all patients. According to current guidelines, SCI was defined as imaging (≥3 mm) or neuropathological evidence of central nervous system infarction, without a history of acute neurological dysfunction attributable to the lesion. <bold>Results. </bold>Silent cerebral infarctions were detected in 34.3% (n = 46) of patients, and infarctions ≥ 15 mm (mean diameter 31.3 mm) were detected in 11.2% (n = 15) of patients. Superficial SCIwere found in 12.7%and basal SCI in 21.6% of cases. In multivariate analysis low creatinine clearance &lt; 90 ml/min was independently associated with small basal SCI (p = 0.04). In univariate analysis age ≥ 65 years was significantly associated with basal SCI, p = 0.004, but not with SCI ≥ 15 mm or superficial SCI. The results of multivariate analysis showed that CHA2DS2VASc score was an independent predictor of superficial SCI; low left atrial appendage velocity (LAAV) &lt; 30 cm/s was independently associated both with SCI ≥ 15 mm (p = 0.03) and superficial SCI (p = 0.02). <bold>Conclusions. </bold>Large and superficial SCI were significantly and independently associated with low LAAV &lt; 30 cm/s and other echocardiographic embolic risk factors and in case of absence of significant large arteries atherosclerosis may be considered as those of cardiac origin. Small basal SCI were associated with age and low creatinine clearance &lt; 90 ml/min which was their independent predictor. CHA2DS2VASc score is useful for assessment of risk of cerebral infarctions even those without history of acute symptoms</abstract>

Cardiac Arrhythmias Department of the SI NSC “M.D. Strazhesko Institute of Cardiology” NAMS of Ukraine, Kyiv, Ukraine

Department of Radiology of the SI NSC “M.D. Strazhesko Institute of Cardiology” NAMS of Ukraine, Kyiv, Ukraine

Clinical and echocardiographic predictors of silent cerebral infarctions in patients with persistent atrial fibrillation

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Seminars in Cardiovascular Medicine

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Volume 20 (2014): Issue 2 (December 2014)

Correlation of cardiac 123I-MIBG imaging with conventional markers of the heart failure

Clinical and echocardiographic predictors of silent cerebral infarctions in patients with persistent atrial fibrillation

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