Magazine et Edition

AHEAD OF PRINT

Volume 69 (2022): Edition 2 (August 2022)

Volume 69 (2022): Edition 1 (January 2022)

Volume 69 (2022): Edition s1 (July 2022)

Volume 68 (2021): Edition 2 (December 2021)

Volume 68 (2021): Edition 1 (January 2021)

Volume 67 (2020): Edition 2 (May 2020)

Volume 67 (2020): Edition 1 (January 2020)

Volume 66 (2019): Edition 2 (November 2019)

Volume 66 (2019): Edition 1 (June 2019)

Volume 65 (2018): Edition 2 (November 2018)

Volume 65 (2018): Edition 1 (June 2018)

Volume 64 (2017): Edition 2 (November 2017)

Volume 64 (2017): Edition 1 (September 2017)

Volume 63 (2016): Edition s12 (December 2016)

Volume 63 (2016): Edition 2 (December 2016)

Volume 63 (2016): Edition 1 (September 2016)

Volume 62 (2015): Edition s10 (September 2015)

Volume 62 (2015): Edition s9 (June 2015)

Volume 62 (2015): Edition 2 (December 2015)

Volume 62 (2015): Edition 1 (June 2015)

Volume 61 (2014): Edition 2 (December 2014)

Volume 61 (2014): Edition 1 (August 2014)

Volume 60 (2013): Edition Supplementum-VIII (March 2013)
Rare disease day in Slovakia, Europlan national conference

Volume 60 (2013): Edition 2 (December 2013)

Volume 60 (2013): Edition 1 (June 2013)

Volume 59 (2012): Edition Supplement-VI (January 2012)
Clinical Pharmacy in the Slovak Republic, dedicated to the associated professor Lívia Magulová, PhD.

Volume 59 (2012): Edition Supplement-VII (February 2012)
Conference abstracts, Rare disease day, conference 29.2.2012, First Slovak conference about rare diseases

Volume 59 (2012): Edition 2 (November 2012)

Volume 59 (2012): Edition 1 (June 2012)

Volume 58 (2011): Edition 1 (January 2011)

Détails du magazine
Format
Magazine
eISSN
2453-6725
Première publication
25 Nov 2011
Période de publication
2 fois par an
Langues
Anglais

Chercher

Volume 69 (2022): Edition s1 (July 2022)

Détails du magazine
Format
Magazine
eISSN
2453-6725
Première publication
25 Nov 2011
Période de publication
2 fois par an
Langues
Anglais

Chercher

6 Articles
Accès libre

Presentations

Publié en ligne: 22 Jun 2022
Pages: 1 - 28

Résumé

Accès libre

Posters

Publié en ligne: 18 Jun 2022
Pages: 29 - 78

Résumé

Accès libre

Secondary prevention of patients with ischaemic stroke after recanalization treatment

Publié en ligne: 13 Jul 2022
Pages: 79 - 81

Résumé

Abstract

We performed a retrospective analysis of 100 patients with ischaemic stroke. All patients underwent intravenous thrombolysis in the acute care setting (avg. 2.8 hours, max 4.5 hours) and 10 of them also underwent mechanical thrombectomy. For 20% of the patients, the stroke was fatal. Door to needle time was 38.46 minutes. Although changes in antithrombotic treatment were introduced due to strokes, there was no significant difference in National Institute of Health Stroke Scale scores between the patients who were on antithrombotic treatment and those who were on no antithrombotic treatment.

Mots clés

  • ischaemic stroke
  • secondary prevention
  • antiplatelet therapy
  • anticoagulant therapy
  • intravenous thrombolysis
Accès libre

Endocrine changes in women with a medically indicated abortion: the study design

Publié en ligne: 25 Jun 2022
Pages: 82 - 83

Résumé

Abstract

A strongly psychosocially demanding situation in the life of a woman is the option of medically indicated abortion. Here we present the design of an ongoing study aiming to examine the stressfulness of life events related to medically indicated abortions by measuring cortisol concentrations in the participants’ hair and saliva. Pilot results show high salivary cortisol concentrations in the majority of the women one day before induced abortion. In half of the group, two months after the abortion, hair cortisol concentrations were higher in comparison to cumulative values from two months before. There were no changes in the second half.

Mots clés

  • medically indicated abortion
  • cortisol
  • stress
  • clinical trial
Accès libre

Immune-Mediated Adverse Effects of Checkpoint Inhibitors: A Clinical Experience

Publié en ligne: 18 Jun 2022
Pages: 84 - 86

Résumé

Abstract

Autoimmune adverse effects of immune checkpoint inhibitors (ICIs) are rare but may be life-threatening. We performed a retrospective analysis of the immune-related adverse effects (irAEs) of ICIs in the Masaryk Memorial Cancer Institute (MMCI) from 2011 to 2021. The ICIs were administered to 648 patients. Severe irAEs were pronounced in 83 patients (12.8 %). Further, we report a case of severe irAE after treatment with ipilimumab and nivolumab. Prednisone, mesalazine, octreotide, infliximab, vedolizumab, and mycophenolate mofetil were used to manage G4 colitis, with partial response. Early diagnosis and appropriate management of irAE are essential in the perspective of further oncological treatment.

Mots clés

  • Immune checkpoint inhibitors
  • immunotherapy
  • adverse effect
  • autoimmunity
Accès libre

Optimisation of flow cytometric detection of intracellular SLAMF receptor-associated adaptor proteins SAP and EAT-2

Publié en ligne: 18 Jun 2022
Pages: 87 - 89

Résumé

Abstract

SAP and EAT-2 are intracellular adaptor proteins that link SLAMF receptors to downstream intracellular signalling pathways. Their expression and functions vary among different types of hematopoietic cells. The roles of SAP and EAT-2 in haematological malignancies are poorly understood. Here, we attempted to optimise a method for the detection of intracellular SAP and EAT-2 by flow cytometry. We found that using PerFix EXPOSE kit for cell fixation and permeabilization ensures optimal results in terms of staining intensity and signal-to-noise ratio.

Mots clés

  • SLAMF receptors
  • SAP
  • EAT-2
  • lymphocytes
  • flow cytometry
6 Articles
Accès libre

Presentations

Publié en ligne: 22 Jun 2022
Pages: 1 - 28

Résumé

Accès libre

Posters

Publié en ligne: 18 Jun 2022
Pages: 29 - 78

Résumé

Accès libre

Secondary prevention of patients with ischaemic stroke after recanalization treatment

Publié en ligne: 13 Jul 2022
Pages: 79 - 81

Résumé

Abstract

We performed a retrospective analysis of 100 patients with ischaemic stroke. All patients underwent intravenous thrombolysis in the acute care setting (avg. 2.8 hours, max 4.5 hours) and 10 of them also underwent mechanical thrombectomy. For 20% of the patients, the stroke was fatal. Door to needle time was 38.46 minutes. Although changes in antithrombotic treatment were introduced due to strokes, there was no significant difference in National Institute of Health Stroke Scale scores between the patients who were on antithrombotic treatment and those who were on no antithrombotic treatment.

Mots clés

  • ischaemic stroke
  • secondary prevention
  • antiplatelet therapy
  • anticoagulant therapy
  • intravenous thrombolysis
Accès libre

Endocrine changes in women with a medically indicated abortion: the study design

Publié en ligne: 25 Jun 2022
Pages: 82 - 83

Résumé

Abstract

A strongly psychosocially demanding situation in the life of a woman is the option of medically indicated abortion. Here we present the design of an ongoing study aiming to examine the stressfulness of life events related to medically indicated abortions by measuring cortisol concentrations in the participants’ hair and saliva. Pilot results show high salivary cortisol concentrations in the majority of the women one day before induced abortion. In half of the group, two months after the abortion, hair cortisol concentrations were higher in comparison to cumulative values from two months before. There were no changes in the second half.

Mots clés

  • medically indicated abortion
  • cortisol
  • stress
  • clinical trial
Accès libre

Immune-Mediated Adverse Effects of Checkpoint Inhibitors: A Clinical Experience

Publié en ligne: 18 Jun 2022
Pages: 84 - 86

Résumé

Abstract

Autoimmune adverse effects of immune checkpoint inhibitors (ICIs) are rare but may be life-threatening. We performed a retrospective analysis of the immune-related adverse effects (irAEs) of ICIs in the Masaryk Memorial Cancer Institute (MMCI) from 2011 to 2021. The ICIs were administered to 648 patients. Severe irAEs were pronounced in 83 patients (12.8 %). Further, we report a case of severe irAE after treatment with ipilimumab and nivolumab. Prednisone, mesalazine, octreotide, infliximab, vedolizumab, and mycophenolate mofetil were used to manage G4 colitis, with partial response. Early diagnosis and appropriate management of irAE are essential in the perspective of further oncological treatment.

Mots clés

  • Immune checkpoint inhibitors
  • immunotherapy
  • adverse effect
  • autoimmunity
Accès libre

Optimisation of flow cytometric detection of intracellular SLAMF receptor-associated adaptor proteins SAP and EAT-2

Publié en ligne: 18 Jun 2022
Pages: 87 - 89

Résumé

Abstract

SAP and EAT-2 are intracellular adaptor proteins that link SLAMF receptors to downstream intracellular signalling pathways. Their expression and functions vary among different types of hematopoietic cells. The roles of SAP and EAT-2 in haematological malignancies are poorly understood. Here, we attempted to optimise a method for the detection of intracellular SAP and EAT-2 by flow cytometry. We found that using PerFix EXPOSE kit for cell fixation and permeabilization ensures optimal results in terms of staining intensity and signal-to-noise ratio.

Mots clés

  • SLAMF receptors
  • SAP
  • EAT-2
  • lymphocytes
  • flow cytometry

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