<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec>
<h3>Background</h3>
<p>A large number of spinal deformities with severe pain are treated with complex and traumatic spinal surgeries. The objectives of our study were to test the hypotheses that bilateral erector spinae plane block (BESPB) as a component of combined anaesthesia for spinal surgeries decreases the quantity of opioid analgesic used and reduces hyperalgesia in comparison with general anaesthesia. We additionally proposed the use of serum testosterone, cortisol, C-reactive protein (CRP), and glucose levels as laboratory markers for hyperalgesia.</p>
</sec>
<sec>
<h3>Methods</h3>
<p>Fifty-two patients who underwent posterior transpedicular fixation of the spine were randomly assigned to either general anaesthesia – control group (CG) – or combined anaesthesia with BESPB – study group (SG). The main outcomes sought were quantity of opioid analgesic perioperatively; hyperalgesia measured with mechanical pain thresholds; and testosterone, cortisol, CRP, and glucose serum levels before and after surgery.</p>
</sec>
<sec>
<h3>Results</h3>
<p>The quantity of fentanyl and morphine was lower in SG in comparison with CG. There was no difference in mechanical pain thresholds in the SG cohort as opposed to CG, where mechanical pain thresholds were lower on the fifth day after surgery. No difference was found before and after surgery in testosterone, cortisol, CRP, and glucose levels in SG. In the CG, the level of testosterone was significantly lower than baseline; the levels of cortisol, CRP, and glucose were significantly higher than baseline on the fifth day after surgery.</p>
</sec>
<sec>
<h3>Conclusion</h3>
<p>Bilateral erector spinae plane block as a component of combined anaesthesia for spinal surgeries reduces the quantity of opioid analgesic used and hyperalgesia. Also, we can propose to use the serum testosterone, cortisol, CRP, and glucose levels as the laboratory markers of hyperalgesia.</p>
</sec>
</abstract>

The Impact of Anaesthesia on Hyperalgesia, Testosterone, Cortisol, C-Reactive Protein, and Glucose Levels After Spine Surgery: Prospective Randomised Controlled Trial

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Volume 30 (2023): Issue 1 (April 2023)

Volume 29 (2022): Issue 1 (July 2022)

Volume 28 (2021): Issue 2 (December 2021)

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Volume 27 (2020): Issue 2 (December 2020)

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Romanian Journal of Anaesthesia and Intensive Care

 The Romanian Journal of Anaesthesia and Intensive Care (Jurnalul Român de Anestezie Terapie Intensivă) is a biannual, in English, with abstracts in English and Romanian, ranked CNCS B+ and indexed Embase, PubMed and Scopus. This journal publishes papers reporting original clinical and experimental researches, reviews, case reports, editorials, guidelines, letters to Editor, book reviews as well as other materials considered adequate by the Editorial committee. In 2002, the Journal changed its name to “Jurnalul Român de Anestezie Terapie Intensivă” (ISSN 2344-2336) to better reflect its primary purpose. It continued to be published in Romanian, with abstracts in both Romanian and English, while 1-2 articles/issue were published in English only. We encouraged all Romanian authors to submit manuscripts written in English, and gradually the number of articles in English increased. The homepage has been written in English (www.jurnalul-anestezie.ro), and is accessible freely on-line; it was established in 2007 with the aim of widening its readership and promoting the Journal abroad. It contained: the Journal title, the title and abstracts of all published articles and the full text of articles in English. In 2008, the Journal benefited from the addition of an international editorial board of 8 members, which was subsequently enlarged to the current 22 members. The number of articles published in English increased, facilitating the inclusion of international experts tasked with reviewing the submitted manuscripts. The peer review enhanced the quality of the publications, stimulated additional original research, and eventually led to the indexing of the Journal in the Elsevier Bibliographic Database (EMBASE and SCOPUS) in 2009, and in the Romanian Ministry of Education CNCSIS B+ database. In 2014, in order to both increase the Journal’s readership internationally, and to attract a broader base of submissions, the Board decided to publish the Journal entirely in English, under the new name, “The Romanian Journal of Anaesthesia and Intensive Care” (ISSN 2392-7518). A native English-speaker editor has been recruited to assist non-native English-speaking authors with style and grammar, and a statistical editor was also added to the editorial process. In 2017 the Journal was accepted to be indexed in the PubMed Central database of the National Library of Medicine USA. The Romanian Journal of Anaesthesia and Intensive Care (Rom J Anaesth Int Care) is intended for anaesthesia and intensive care clinicians, and for specialists in emergency medical care, pain research and pain management. The principal aim is to stimulate and promote scientific discovery by publishing research papers and manuscripts accompanied by editorials written by experts in the field. The editorials seek to place the research findings in the appropriate clinical context, highlighting how the information is directly applicable to patient care and how it benefits the clinician and the patient. The Journal also seeks to inform and update anaesthesiologists about clinical and regulatory developments by publishing reviews and educational materials such as Clinical Guidelines of the European Society of Anaesthesiology and those of our Romanian National Society.  Archiving  Sciendo archives the contents of this journal in Portico - digital long-term preservation service of scholarly books, journals and collections.  Plagiarism Policy  The editorial board is participating in a growing community of Similarity Check System's users in order to ensure that the content published is original and trustworthy. Similarity Check is a medium that allows for comprehensive manuscripts screening, aimed to eliminate plagiarism and provide a high standard and quality peer-review process. 

Romanian Journal of Anaesthesia and Intensive Care

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The Impact of Anaesthesia on Hyperalgesia, Testosterone, Cortisol, C-Reactive Protein, and Glucose Levels After Spine Surgery: Prospective Randomised Controlled Trial

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