Accuracy of noninvasive scoring systems to assess advanced liver fibrosis in Thai patients with nonalcoholic fatty liver disease
, , , , et | 31 mars 2017
À propos de cet article
Article Category: Brief Communication (Original)
Publié en ligne: 31 mars 2017
Pages: s49 - s55
DOI: https://doi.org/10.5372/1905-7415.1000.521
Mots clés
© 2016 Sombat Treeprasertsuk, Panida Piyachaturawat, Tanassanee Soontornmanokul, Naruemon Wisedopas-Klaikaew, Piyawat Komolmit, Pisit Tangkijavanich
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Figure 1
Baseline characteristics of 139 Thai patients with nonalcoholic fatty liver disease
| Variable | Total (n=139) | No/mild fibrosis Advanced fibrosis (F0-F2)(n=139) | Advanced fibrosis (F3-F4)(n=9) | P |
|---|---|---|---|---|
| Age (years) | 40.9 (13.3) | 40.3 (13.0) | 48.8 (15.5) | 0.07 Student |
| Male sex (%) | 65 (47%) | 61 (47%) | 4 (44%) | 1.00t |
| BMI (kg/m2) median | 36.1 (14.7) | 40.6 (14.8) | 29.4 (8.6) | 0.01 Student |
| BMI >28 (kg/m2) | 102 (73%) | 97 (75%) | 5 (56%) | 0.23t |
| Diabetes mellitus (DM) | 53 (38%) | 47 (36%) | 6 (67%) | 0.08t |
| IFG/DM | 75 (54%) | 67 (52%) | 8 (89%) | 0.04t |
| AST (IU/L) median | 38.0 (39.4) | 38.0 (34.6) | 39 (81.2) | 0.24 Mann-Whitney |
| ALT (IU/L) median | 56.0 (47.2) | 56.0 (47.7) | 59.0 (40.7) | 0.29* |
| Albumin (g/L) | 4.4 (0.4) | 4.4 (0.4) | 4.4 (0.3) | 0.84 Student |
| Platelet (×109/L) | 267 (64.2) | 270 (64.3) | 222 (43.7) | 0.02 Mann-Whitney |
| Total cholesterol (mg/dL) | 198 (46.6) | 197 (45.5) | 214 (60.8) | 0.44 Mann-Whitney |
| Triglyceride (mg/dL) | 146 (60.8) | 145 (60.9) | 164 (59.6) | 0.31 Mann-Whitney |
| HDL (mg/dL) | 45.6 (12.1) | 45.5 (12.4) | 46.8 (8.1) | 0.53 Mann-Whitney |
| LDL (mg/dL) | 125 (42.1) | 125 (41.1) | 135 (56.2) | 0.61 Mann-Whitney |
| FPG (mg/dL) | 112 (33.2) | 109 (30.9) | 142 (49.2) | 0.01 Mann-Whitney |
| HbA1C (%) | 7.38 (8.7) | 7.36 (9.0) | 7.59 (1.7) | 0.08 Student |
| AST/ALT ratio | 0.78 (0.37) | 0.78 (0.38) | 0.85 (0.38) | 0.59 Student |
| BARD score | 0.48 Student | |||
| 0 | 10 (7%) | 10 (8%) | 0 (0) | |
| 1 | 45 (32%) | 43 (33%) | 2 (22%) | |
| 2 | 41 (30%) | 37 (29%) | 4 (44%) | |
| 3 | 26 (19%) | 24 (19%) | 2 (22%) | |
| 4 | 17 (12%) | 16 (12%) | 1 (11%) | |
| FIB-4 score | 0.98 (0.79) | 0.91 (0.61) | 1.9 (1.9) | 0.17 Student |
| NAFLD Fibrosis Score | -1.37 (1.70) | -1.418 (1.748) | -0.772 (0.668) | 0.03 Student |
Comparison of the diagnostic ability of the 4 noninvasive scoring systems for advanced fibrosis between 2 studies
| Shah et al. [ | Present study | |
|---|---|---|
| Baseline characteristics | ||
| Impaired fasting glucose or DM | 19.4% | 54% |
| Body mass index (mean; kg/m2) | 34 (6.3) | 36 (14.7) |
| %F3-F4 | 54% | 6% |
| AST/ALT | 0.74 | 0.57 |
| BARD score | 0.70 | 0.58 |
| FIB-4 score | 0.80 | 0.74 |
| NAFLD Fibrosis Score | 0.77 | 0.66 |
Comparison of the 4 noninvasive scoring systems for the diagnosis of advanced fibrosis in 139 Thai patients with nonalcoholic fatty liver disease
| Non-invasive scoring system | Cutoff ≥ | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy | Patients avoiding liver biopsy | False negative result |
|---|---|---|---|---|---|---|---|---|
| AST/ALT | 0.8 | 44.4 | 64.6 | 8.0 | 94.4 | 63 | 89 (64%) | 5 (4%) |
| BARD score | 2.0 | 77.8 | 40.0 | 8.2 | 96.3 | 42 | 54 (39%) | 2 (1%) |
| FIB-4 score | 1.3 | 55.6 | 83.5 | 19.2 | 96.4 | 79 | 110 (81%) | 4 (3%) |
| NAFLD | –1.455 | 88.9 | 48.0 | 11.0 | 98.4 | 48 | 61 (46%) | 1 (1%) |
| Fibrosis Score |