<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_1905-7415.0906.447_s_001_w2aab3b7b3b1b6b1aab1c16b1Aa"><h3>Background</h3><p>Whether patients with coronary heart disease (CHD) and resistance to aspirin found by in vitro tests are at a greater risk of major adverse cardiovascular events (MACEs) is controversial.</p></sec><sec id="j_1905-7415.0906.447_s_002_w2aab3b7b3b1b6b1aab1c16b2Aa"><h3>Objective</h3><p>To identify any association between resistance to aspirin found by in vitro tests and MACEs in patients with unstable angina pectoris (UAP).</p></sec><sec id="j_1905-7415.0906.447_s_003_w2aab3b7b3b1b6b1aab1c16b3Aa"><h3>Methods</h3><p>Previously we demonstrated that 38 of 104 patients admitted to hospital with UAP showed resistance to aspirin using whole blood aggregometry (WBA). In the present study, the same cohort was observed during a 6-month follow-up. The primary end points were MACEs, including cardiovascular death, nonfatal myocardial infarction, revascularization, stroke/transient ischemic attack, or worsening UAP that required the patient to be readmitted to hospital.</p></sec><sec id="j_1905-7415.0906.447_s_004_w2aab3b7b3b1b6b1aab1c16b4Aa"><h3>Results</h3><p>During the course of 6 months, only 1 patient in the aspirin-sensitive group was lost in follow-up, and MACEs occurred in 24 patients. Patients with resistance to aspirin found by WBA did not apparently have a higher risk of MACEs compared with patients who were aspirin-sensitive (29% vs 20%, P > 0.05). Cox regression analysis showed that resistance to aspirin found by WBA appeared to have no significant correlation with 6-month clinical outcome (HR 1.56, 95% CI 0.70-3.48, P > 0.05).</p></sec><sec id="j_1905-7415.0906.447_s_005_w2aab3b7b3b1b6b1aab1c16b5Aa"><h3>Conclusion</h3><p>Aspirin resistance, as defined by WBA, was not associated with an increased risk of MACEs in patients with UAP in a 6-month follow-up. Clarification of the clinical significance of aspirin responsiveness detected by platelet function tests requires further investigation in larger longitudinal studies.</p></sec></abstract>

BackgroundWhether patients with coronary heart disease (CHD) and resistance to aspirin found by in vitro tests are at a greater risk of major adverse cardiovascular events (MACEs) is controversial.ObjectiveTo identify any association between resistance to aspirin found by in vitro tests and MACEs in patients with unstable angina pectoris (UAP).MethodsPreviously we demonstrated that 38 of 104 patients admitted to hospital with UAP showed resistance to aspirin using whole blood aggregometry (WBA). In the present study, the same cohort was observed during a 6-month follow-up. The primary end points were MACEs, including cardiovascular death, nonfatal myocardial infarction, revascularization, stroke/transient ischemic attack, or worsening UAP that required the patient to be readmitted to hospital.ResultsDuring the course of 6 months, only 1 patient in the aspirin-sensitive group was lost in follow-up, and MACEs occurred in 24 patients. Patients with resistance to aspirin found by WBA did not apparently have a higher risk of MACEs compared with patients who were aspirin-sensitive (29% vs 20%, P > 0.05). Cox regression analysis showed that resistance to aspirin found by WBA appeared to have no significant correlation with 6-month clinical outcome (HR 1.56, 95% CI 0.70-3.48, P > 0.05).ConclusionAspirin resistance, as defined by WBA, was not associated with an increased risk of MACEs in patients with UAP in a 6-month follow-up. Clarification of the clinical significance of aspirin responsiveness detected by platelet function tests requires further investigation in larger longitudinal studies.

Aspirin responsiveness and 6-month clinical outcome observed in a cohort study of patients with unstable angina pectoris

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

BackgroundWhether patients with coronary heart disease (CHD) and resistance to aspirin found by in vitro tests are at a greater risk of major adverse...

Aspirin responsiveness and 6-month clinical outcome observed in a cohort study of patients with unstable angina pectoris

Article Category: Original article

Publié en ligne: 31 janv. 2017

Pages: 751 - 759

DOI: https://doi.org/10.5372/1905-7415.0906.447

Mots clés
Aggregometry, antiplatelet, aspirin responsiveness, major adverse cardiovascular events, unstable angina pectoris

© 2015 Jiabei Li, Yanqi Zhang, Juan Wang, Dehui Qian, Hui Guo, Mingbao Song, Xiaojing Wu, Jun Jin, Junfu Huang, Lan Huang

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Aspirin responsiveness and 6-month clinical outcome observed in a cohort study of patients with unstable angina pectoris

Article Category: Original article

Publié en ligne: 31 janv. 2017

Pages: 751 - 759

DOI: https://doi.org/10.5372/1905-7415.0906.447

Mots clésAggregometry, antiplatelet, aspirin responsiveness, major adverse cardiovascular events, unstable angina pectoris

© 2015 Jiabei Li, Yanqi Zhang, Juan Wang, Dehui Qian, Hui Guo, Mingbao Song, Xiaojing Wu, Jun Jin, Junfu Huang, Lan Huang

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
Aggregometry, antiplatelet, aspirin responsiveness, major adverse cardiovascular events, unstable angina pectoris