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The emergence of lincosamide and macrolide resistance in Streptococcus pyogenes from Pakistan

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Background

Many reports from developing and developed countries have shown increased resistance against macrolides and other antibiotics among Streptococcus pyogenes or group A streptococci (GAS).

Objectives

To study the current resistance pattern of S. pyogenes in Pakistan to commonly prescribed antibiotics.

Materials and Methods

Altogether, 85 (53%) of S. pyogenes strains were isolated and collected from 160 various clinical specimens from patients in Pakistan.

Results

Among other strains, 51 (32%) group D streptococci, 15 (9%) group B streptococci, 7 (4%) group G streptococci, and 2 (1%) group C streptococci were also identified. Predominantly, S. pyogenes were isolated from throat swabs (55%), followed by pus (17%), tissues (12%), and blood or wound swabs (7%). The majority of the S. pyogenes isolates were collected during the rainy season (55%) followed by cool season (40%), while merely 5% strains were isolated during the hot season, indicating a correlation of GAS incidence with seasonal changes. The highest rate of resistance was observed against clindamycin (29%), followed by macrolides (20%), and ciprofloxacin (14%). However, all strains of GAS were sensitive to penicillin and co-amoxiclav.

Conclusions

The emergence of lincosamide and macrolide resistance among GAS is a major problem worldwide which is probably due to misuse of antibiotics, self-medication, or frequent use of these antibiotics.

eISSN:
1875-855X
Langue:
Anglais
Périodicité:
6 fois par an
Sujets de la revue:
Medicine, Assistive Professions, Nursing, Basic Medical Science, other, Clinical Medicine