Risk factors for osteoporosis and the relationship between osteoporosis and hemoglobin level in adult patients with thalassemia in Rajavithi hospital

Parameter	Osteoporosis (Yes)	Osteoporosis (No)	Crude OR	95%CI	P
Age
≥35 years	11	87
<35 years	11	81	0.93	0.38–2.26	0.875
Sex
Female	14	118
Male	8	50	1.30	0.08–2.53	0.53
Thalassemia type
Intermedia	19	119
Minor	3	49	0.38	0.11–1.36	0.2
Blood transfusion
Dependent	9	42
Independent	13	126	0.48	0.19–1.21	0.11
Ferritin
≥1000 ng/ml	16	94
<1000 ng/ml	6	73	2.07	0.83–5.93	0.14
Iron Chelation
Yes	5	92
No	17	76	0.24	0.09–0.69	0.005*
Body mass index (kg/m²)
Low (<20)	17	88
Normal (≥20)	5	80	3.09	1.06–7.15	0.027*
Splenectomy
Yes	8	49
No	14	119	1.33	0.59–3.00	0.49
Physical activity
Low (<600 METs-minutes/week)	12	63
Normal (≥600)	10	105	1.84	0.84–4.04	0.12
Vitamin D level
Low (<20ng/ml)	9	58
Normal	13	110	1.27	0.57–2.82	0.56
Daily calcium intake
Low (<800 mg/d)	18	138
Sufficient	4	30	0.98	0.31–3.10	0.97

Parameter	Adjusted OR	95%CI	P
Age: ≥35 years old	0.90	0.31–2.59	0.84
Sex: female/male	0.97	0.34–2.79	0.96
Hemoglobin level: ≤10 mg/mL	0.71	0.16–3.21	0.65
Type of Thal.: int. vs. minor	1.78	0.40–7.94	0.45
Splenectomy: yes	0.52	0.17–1.61	0.26
Blood transfusion: dependent	1.54	0.52–4.59	0.44
Ferritin: ≥1000 ng/mL	0.72	0.22–4.21	0.60
Iron chelation: yes	0.32	0.08–1.14	0.076*
BMI: low (<20 kg/m²)	2.92	0.9–9.34	0.070*
Physical activity: low	2.33	0.84–6.43	0.10
Vitamin D level: low	1.26	0.46–3.36	0.66
Daily Ca intake: low	0.81	0.14–4.60	0.81

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Sujets de la revue:: Medicine, Assistive Professions, Nursing, Basic Medical Science, other, Clinical Medicine