<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_1905-7415.0902.378_s_004_s_001_w2aab3b7b2b1b6b1aab1c16b1Aa"><h3>Background</h3><p>Asthma is a chronic inflammatory disease of airways. Gastroesophageal reflux disease (GERD) is known to be associated with worsening asthma. We hypothesized that treatment of GERD in asthmatics will improve asthma control and quality of life. We reviewed our experience of treatment of GERD in asthmatics in Thailand.</p></sec><sec id="j_1905-7415.0902.378_s_004_s_002_w2aab3b7b2b1b6b1aab1c16b2Aa"><h3>Objectives</h3><p>To study the effects of omeprazole for treatment of GERD in patients with poorly controlled asthma on pulmonary function tests and asthma control test (ACT) scores.</p></sec><sec id="j_1905-7415.0902.378_s_004_s_003_w2aab3b7b2b1b6b1aab1c16b3Aa"><h3>Methods</h3><p>This study was conducted at King Chulalongkorn Memorial Hospital between August 2009 and December 2010. Patients with partly controlled and uncontrolled asthma who were found to have GERD by 24 hour esophageal pH monitoring were administered omeprazole 40 mg per day for 8 weeks. Pulmonary function tests and ACT scores before and after treatment were compared at 4-weeks and 8-weeks follow up.</p></sec><sec id="j_1905-7415.0902.378_s_004_s_004_w2aab3b7b2b1b6b1aab1c16b4Aa"><h3>Results</h3><p>Twenty four patients were included in this study. None of them had asthmatic attacks during the study. After 4 and 8 weeks of omeprazole treatment, the mean FEV1 (2.20 ± 0.64 L, 2.36 ± 0.58 L, respectively) and the mean ACT score (20.82 ± 3.30, 23.00 ± 1.69, respectively) were significantly higher than the pretreatment values (mean FEV1 1.99 ± 0.56 L and ACT score 16.36 ± 3.97) (<italic>P</italic> &lt; 0.05).</p></sec><sec id="j_1905-7415.0902.378_s_004_s_005_w2aab3b7b2b1b6b1aab1c16b5Aa"><h3>Conclusion</h3><p>High-dose omeprazole may improve pulmonary function and the level of asthma control in Thai patients with partly controlled or uncontrolled asthma and coexisting GERD.</p></sec></abstract>

BackgroundAsthma is a chronic inflammatory disease of airways. Gastroesophageal reflux disease (GERD) is known to be associated with worsening asthma. We hypothesized that treatment of GERD in asthmatics will improve asthma control and quality of life. We reviewed our experience of treatment of GERD in asthmatics in Thailand.ObjectivesTo study the effects of omeprazole for treatment of GERD in patients with poorly controlled asthma on pulmonary function tests and asthma control test (ACT) scores.MethodsThis study was conducted at King Chulalongkorn Memorial Hospital between August 2009 and December 2010. Patients with partly controlled and uncontrolled asthma who were found to have GERD by 24 hour esophageal pH monitoring were administered omeprazole 40 mg per day for 8 weeks. Pulmonary function tests and ACT scores before and after treatment were compared at 4-weeks and 8-weeks follow up.ResultsTwenty four patients were included in this study. None of them had asthmatic attacks during the study. After 4 and 8 weeks of omeprazole treatment, the mean FEV1 (2.20 ± 0.64 L, 2.36 ± 0.58 L, respectively) and the mean ACT score (20.82 ± 3.30, 23.00 ± 1.69, respectively) were significantly higher than the pretreatment values (mean FEV1 1.99 ± 0.56 L and ACT score 16.36 ± 3.97) (P < 0.05).ConclusionHigh-dose omeprazole may improve pulmonary function and the level of asthma control in Thai patients with partly controlled or uncontrolled asthma and coexisting GERD.

Observational study of omeprazole for gastroesophageal reflux on pulmonary function in adult asthmatics

Department of Medicine, Faculty of Medicine

King Chulalongkorn Memorial Hospital, Thai Red Cross Society

Division of Gastroenterology, Department of Medicine, Faculty of Medicine

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

BackgroundAsthma is a chronic inflammatory disease of airways. Gastroesophageal reflux disease (GERD) is known to be associated with worsening asthma. We...

Observational study of omeprazole for gastroesophageal reflux on pulmonary function in adult asthmatics

Article Category: Original article

Publié en ligne: 31 janv. 2017

Pages: 139 - 145

DOI: https://doi.org/10.5372/1905-7415.0902.379

Mots clés
Asthma, GERD, pulmonary function test, omeprazole, symptom assessment

© 2017 Nattapong Jaimchariyatam, Phurin Haprasert, Sutep Gonchanvit, Somkiat Wongtim

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Observational study of omeprazole for gastroesophageal reflux on pulmonary function in adult asthmatics

Article Category: Original article

Publié en ligne: 31 janv. 2017

Pages: 139 - 145

DOI: https://doi.org/10.5372/1905-7415.0902.379

Mots clésAsthma, GERD, pulmonary function test, omeprazole, symptom assessment

© 2017 Nattapong Jaimchariyatam, Phurin Haprasert, Sutep Gonchanvit, Somkiat Wongtim

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
Asthma, GERD, pulmonary function test, omeprazole, symptom assessment