<abstract xmlns="http://www.w3.org/1999/xhtml"> Background: Ischemia/reperfusion (I/R) injury is a potentially devastating condition, associated with a systemic inflammatory response. It occurs during shock, transplant procedures, or vascular surgery. Objective: We evaluated the protective effects of Fenofibrate (FEN) over intestinal I/R injury. Materials and methods: Intestinal I/R was induced in male Wistar rats by clamping the superior mesenteric artery for 60 minutes, followed by 60 minutes of reperfusion. Rats either received saline or FEN (100 mg/k, via gavage) daily, for three days before inducing I/R. Sham operated rats were used as normal controls. At the end of the procedure, tissue and blood samples were obtained. Serum concentrations of AST, ALT, LDH, tumor necrosis factor-alpha (TNF-alpha), malonaldehyde (MDA), and total antioxidant capacity (TAC) were determined. A histopathological analysis was also performed. Results: After I/R, there was evident tissue injury, as well as serum elevations of AST, ALT, and LDH concentrations. These alterations were reduced by FEN treatment. TNF-alpha concentrations were increased in saline treated animals when compared with FEN treated group (2.26±1 ng/ml vs. 0.23±0.41 ng/ml, respectively, p &lt;0.05). A similar pattern was observed in MDA levels (7.42±1.72 μM/ml vs. 1.72±0.61 μM/ml, respectively, p &lt;0.05). TAC was reduced in saline treated animals (2.05±0.36 Trolox-Equivalents), but preserved in the FEN treated group (3.08±0.36 Trolox-Equivalents, p &lt;0.05). Conclusion: FEN reduced intestinal I/R injury, probably due to anti-inflammatory and antioxidant properties. Its usefulness as a treatment for I/R should be studied. </abstract>

Background: Ischemia/reperfusion (I/R) injury is a potentially devastating condition, associated with a systemic inflammatory response. It occurs during shock, transplant procedures, or vascular surgery. Objective: We evaluated the protective effects of Fenofibrate (FEN) over intestinal I/R injury. Materials and methods: Intestinal I/R was induced in male Wistar rats by clamping the superior mesenteric artery for 60 minutes, followed by 60 minutes of reperfusion. Rats either received saline or FEN (100 mg/k, via gavage) daily, for three days before inducing I/R. Sham operated rats were used as normal controls. At the end of the procedure, tissue and blood samples were obtained. Serum concentrations of AST, ALT, LDH, tumor necrosis factor-alpha (TNF-alpha), malonaldehyde (MDA), and total antioxidant capacity (TAC) were determined. A histopathological analysis was also performed. Results: After I/R, there was evident tissue injury, as well as serum elevations of AST, ALT, and LDH concentrations. These alterations were reduced by FEN treatment. TNF-alpha concentrations were increased in saline treated animals when compared with FEN treated group (2.26±1 ng/ml vs. 0.23±0.41 ng/ml, respectively, p <0.05). A similar pattern was observed in MDA levels (7.42±1.72 μM/ml vs. 1.72±0.61 μM/ml, respectively, p <0.05). TAC was reduced in saline treated animals (2.05±0.36 Trolox-Equivalents), but preserved in the FEN treated group (3.08±0.36 Trolox-Equivalents, p <0.05). Conclusion: FEN reduced intestinal I/R injury, probably due to anti-inflammatory and antioxidant properties. Its usefulness as a treatment for I/R should be studied.

Fenofibrate protects the intestine against ischemia/ reperfusion injury

Departamento de Fisiologia, Universidad Autonoma de Nuevo Leon, School of Medicine, Monterrey, Nuevo Leon, Nuevo Leon 64460,

Departamento de Fisiologia, Universidad Autonoma de Nuevo Leon, School of Medicine, Monterrey, Nuevo Leon 64460,

Unidad de Higado, Departamento de Medicina Interna, Universidad Autonoma de Nuevo Leon, School of Medicine, Monterrey, Nuevo Leon 64460,

Servicio de Anatomia Patologica y Citopatologia, Hospital Universitario “Jose Eleuterio Gonzalez”, Monterrey, Nuevo Leon 64460,

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Fenofibrate protects the intestine against ischemia/ reperfusion injury"}

Background: Ischemia/reperfusion (I/R) injury is a potentially devastating condition, associated with a systemic inflammatory response. It occurs during shock,...

Fenofibrate protects the intestine against ischemia/ reperfusion injury

Article Category: Brief communication (Original)

Publié en ligne: 04 févr. 2017

Pages: 279 - 283

DOI: https://doi.org/10.5372/1905-7415.0602.054

Mots clés
Fenofibrate, injury, intestine, ischemia/ reperfusion, rat

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Fenofibrate protects the intestine against ischemia/ reperfusion injury

Article Category: Brief communication (Original)

Publié en ligne: 04 févr. 2017

Pages: 279 - 283

DOI: https://doi.org/10.5372/1905-7415.0602.054

Mots clésFenofibrate, injury, intestine, ischemia/ reperfusion, rat

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mots clés
Fenofibrate, injury, intestine, ischemia/ reperfusion, rat