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Mean values of main left ventricular diastolic function parameters in the entire study population at baseline, by age group

2 – 5 years 6 – 9 years 10 – 13 years 14 – 18 years Total
E-wave (m/s) 1.02 (±0.10) 0.99 (±0.13) 0.88 (±0.11) 0.87 (±0.10) 0.92 (±0.13)
A-wave (m/s) 0.63 (±0.04) 0.62 (±0.13) 0.59 (±0.11) 0.57 (±0.09) 0.60 (±0.11)
E/A 1.59 (±0.17) 1.66 (±0.35) 1.54 (±0.31) 1.56 (±0.28) 1.58 (±0.31)
DT (ms) 105.6 (±23.78) 136.9 (±23.92) 134.63 (±24.76) 148.55 (±27.22) 137.21(±27.28)
IVRT 51.40 (±7.03) 63.23 (±14.78) 65.20 (±13.66) 71.05 (±9.03) 65.26 (±13.47)
Vp 73.68 (±10.81) 65.67 (±14.49) 66.77 (±17.53) 60.13 (±14.42) 65.11 (±15.79)
E/Vp 1.42 (±0.28) 1.61 (±0.47) 1.41 (±0.39) 1.52 (±0.33) 1.50 (±0.40)
e’ lateral septal 13.68 (±1.80) 12.67 (±2.23) 13.43 (±1.37) 12.98 (±2.74) 13.10 (±2.07)
E/e’ septal 7.35 (±0.55) 8.26 (±3.1) 6.56 (±0.66) 7 (±1.51) 7.24 (±2.03)
e’ lateral lateral 18.32 (±2.85) 17.73 (±3.61) 19.19 (±2.68) 19.17 (4.12) 18.68 (±3.5)
E/e’ lateral 5.59 (±0.96) 5.88 (±1.65) 4.66 (±0.84) 4.72 (±0.88) 5.11 (±1.28)

Comparison of mean stroke volume and cardiac output, normalized to body surface area

Excess weight M (SD) Controls M (SD) Statistical analysis
Stroke volume normalized to body surface area 28.97 (5.83) 34.49 (7.77) t(66)= −3.3P=0.00195% C.I. [−8.8, −2.21]
Cardiac index 2.49 (0.57) 2.9 (0.91) t(39.6)= −2.1P=0.04195% C.I. [−0.81, −0.01]

Baseline participant characteristics

Category Excess weight Control P value
Fasting plasma glucoseMean (mg/dl) ±SD 93.02 ± 8.75 90.61 ± 8.11 NS
Lipid profile
Modifieda total cholesterol (%) 64.9 26.9 <0.01
Modifieda triglycerides (%) 50 20 <0.05
HTN prevalence (ABPM)b (%) 14.3 4 NS
Metabolic syndromec (%) 21.1 0 <0.05

Comparison of mean stroke volume and cardiac output, normalized to body surface area to its age-specific allometric power for individuals under 18 years of age5

Excess weight M (SD) Controls M (SD) Statistical analysis
Stroke volume normalized to body surface area0.82 31.12 (6.44) 36.83 (8.73) t(66)= −3.1P=0.00395% C.I. [−9.38, −2.03]
Cardiac output normalized to body surface area0.53 3 (0.72) 3.4 (1.06) t(66)= −1.87P=0.06595% C.I. [−0.84, −0.02]

Left ventricular ejection fraction in the excess weight and normal weight groups. Percentages are derived from total valid measurements in all participants, regardless of weight status

Teichholz Simpson's biplane
EW NW EW NW
LVEF <50%, n (%) 0 (0%) 0 (0%) 1 (1.51%) 0 (0%)
LVEF 50–54.9%, n (%) 2 (2.81%) 0 (0%) 6 (9.09%) 0 (0%)
LVEF 55–59.9%, n (%) 1 (1.4%) 0 (0%) 13 (19.69%) 4 (6.06%)
LVEF 60–69.9%, n (%) 15 (21.12%) 9 (12.67%) 18 (27.27%) 19 (28.78%)
LVEF ≥70%, n (%) 25 (35.21%) 19 (26.76%) 2 (3.03%) 3 (4.54%)