<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>BACKGROUND</h3>
<p>Acquired hemophilia A (AHA) is a rare, severe bleeding disorder caused by the development of autoantibodies against FVIII that may be idiopathic or secondary to medical conditions. Postpartum AHA can occur as early as 1–4 months after delivery or as late as 1-year postpartum.</p>
</sec>
<sec><h3>CASE REPORT</h3>
<p>A 20-year-old female presented with vaginal bleeding 20 days after delivery, then ecchymotic patches developed 2 months later, followed by hematuria 2 months after that. Laboratory investigation revealed isolated, prolonged partial thromboplastin time that was not corrected by mixing 50:50 with fresh normal plasma. FVIII activity was markedly deficient, with a high titer of immediate-acting FVIII inhibitor antibodies.</p>
</sec>
<sec><h3>CONCLUSION</h3>
<p>The case was diagnosed as postpartum AHA with a good response to the combined steroids and cyclophosphamide treatment.</p>
</sec>
</abstract>

BACKGROUND
Acquired hemophilia A (AHA) is a rare, severe bleeding disorder caused by the development of autoantibodies against FVIII that may be idiopathic or secondary to medical conditions. Postpartum AHA can occur as early as 1–4 months after delivery or as late as 1-year postpartum.

CASE REPORT
A 20-year-old female presented with vaginal bleeding 20 days after delivery, then ecchymotic patches developed 2 months later, followed by hematuria 2 months after that. Laboratory investigation revealed isolated, prolonged partial thromboplastin time that was not corrected by mixing 50:50 with fresh normal plasma. FVIII activity was markedly deficient, with a high titer of immediate-acting FVIII inhibitor antibodies.

CONCLUSION
The case was diagnosed as postpartum AHA with a good response to the combined steroids and cyclophosphamide treatment.

Acquired Postpartum Hemophilia A Presentation of Severe Hematuria: A Case Report

Department of Clinical and Chemical Pathology, Faculty of Medicine

Department of Internal Medicine and Clinical Hematology, Faculty of Medicine

South East European Journal of Immunology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Acquired Postpartum Hemophilia A Presentation of Severe Hematuria: A Case Report"}

BACKGROUND
Acquired hemophilia A (AHA) is a rare, severe bleeding disorder caused by the development of autoantibodies against FVIII that may be idiopathic or...

Acquired Postpartum Hemophilia A Presentation of Severe Hematuria: A Case Report

Publié en ligne: 03 janv. 2024

Pages: 80 - 82

Reçu: 21 mai 2023

Accepté: 26 juil. 2023

DOI: https://doi.org/10.3889/seejim.2023.6041

Mots clés
Acquired hemophilia A, Postpartum, Haematuria

© 2023 Wafaa M. Abdelghany, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Acquired Postpartum Hemophilia A Presentation of Severe Hematuria: A Case Report

Publié en ligne: 03 janv. 2024

Pages: 80 - 82

Reçu: 21 mai 2023

Accepté: 26 juil. 2023

DOI: https://doi.org/10.3889/seejim.2023.6041

Mots clésAcquired hemophilia A, Postpartum, Haematuria

© 2023 Wafaa M. Abdelghany, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
Acquired hemophilia A, Postpartum, Haematuria