Anti-Inflammatory And Immunomodulating Activity of the 1(10) Β-Epoxy-5,7α,6β(Н)-Guai-3(4),11(13)-Dien-6,12-Olide

1 Shi L. Isolation, purification, and immunomodulatory activity in vitro of three polysaccharides from roots of Cudrania tricuspidata. Acta Biochim Biophys Sin (Shanghai). 2011;43(5):418-24. https://doi.org/10.1093/abbs/gmr024 PMid:21467071 Search in Google Scholar

2 Sülsen VP, Martino VS. Sesquiterpene Lactones: Advances in their Chemistry and Biological Aspects. Germany: Springer; 2018. p. 371. Search in Google Scholar

3 Merfort I. Perspectives on sesquiterpene lactones in inflammation and cancer. Curr Drug Targets. 2011;12(11):1560-73. https://doi.org/10.2174/138945011798109437 PMid:21561425 Search in Google Scholar

4 Peterková L, Rimpelová S, Kmoníčková E, Ruml T. Sesquiterpene lactones: From weed to remedy (Seskviterpenové laktony: Od plevelu k léčivu. J Chem Listy. 2019;113(3):149-55. Search in Google Scholar

5 Harmatha J, Buděšinsky M, Vokač K, Kmoničkova E, Zidek Z. Targeted modification of trilobolide and search for related sesquiterpenes with immunobiological properties. Planta Med. 2011;77:PM3. https://doi.org/10.1055/s-0031-1282761 Search in Google Scholar

6 Harmathaa J, Buděšinsky M, Jurašekb M, Zimmermannb T, Drašarb P, Zidekc Z, et al. Structural modification of trilobolide for upgrading its immunobiological properties and reducing its cytotoxic action. Fitoterapia. 2019;134:88-95. https://doi.org/10.1016/j.fitote.2019.02.002 PMid:30731148 Search in Google Scholar

7 Harmatha J, Buděšínský M, Vokáč K, Kostecká P, Kmoníčková E, Zídek Z. Trilobolide and related sesquiterpene lactones from Laser trilobum possessing immunobiological properties. Fitoterapia. 2013;89:157-66. https://doi.org/10.1016/j.fitote.2013.05.025 PMid:23747321 Search in Google Scholar

8 Harmatha J, Vokáč K, Buděšínský M, Zídek Z, Kmoníčková E. Immunobiological properties of sesquiterpene lactones obtained by chemically transformed structural modifications of trilobolide. Fitoterapia. 2015;107:90-9. https://doi.org/10.1016/j.fitote.2015.10.002 PMid:26474674 Search in Google Scholar

9 Kmonickova E, Rimpelova S, Jurasek M, Dzubak P, Sedlak D, Zidek Z, et al. Pharmacological Activities Of Sesquiterpene Lactone Trilobolide And Its Conjugates As a Promising Compounds For Anticancer And Immunomodulatory Therapies. Article in Proceedings for Annual Meeting of the Japanese Pharmacological Society; 2018. https://doi.org/10.1254/jpssuppl.WCP2018.0_OR34-3 Search in Google Scholar

10 Mironov AN. Guidelines for Conducting Preclinical Studies of Drugs. Part one/M Grif and K. Moskow: 2012. p. 944. Search in Google Scholar

11 Guidelines for the Experimental (Preclinical) Study of New Pharmacological Substances. Under the General Editorship of Corresponding Member of the Russian Academy of Medical Sciences, Professor R.U. Khabriev. 2^nd ed. Moscow: Medicine; 2005. p. 637. Search in Google Scholar

12 Lyb G, Schmidt TJ, Pahl HL, Merfort I. Anti-inflammatory activity of Arnica tincture (DAB 1998) using the transcription factor NF-KB as molecular target. Pharm Pharmacol Lett. 1999;9(1):5-8. Search in Google Scholar

13 Mozaffari F, Lindemalm C, Choudhury A, Granstam-Bjorneklett H, Helander I, Lekander M, et al. NK-cell and T-cell functions in patients with breast cancer: Effects of surgery and adjuvant chemo-and radiotherapy. Br J Cancer. 2007;97:105-11. https://doi.org/10.1038/sj.bjc.6603840 PMid:17551492 Search in Google Scholar

14 Orange SJ, Balias KZ. Natural killer cells in human health and disease. Clin Immunol. 2006;118(1):1-10. https://doi.org/10.1016/j.clim.2005.10.011 PMid:16337194 Search in Google Scholar

15 Jia QQ, Wang JC, Long J, Zhao Y, Chen SJ, Zhai JD, et al. Sesquiterpene lactones and their derivatives inhibit high glucose-induced NF-kB activation and MCP-1 and TGF-β1 expression in rat mesangial cells. Molecules. 2013;18(10):13061-77. https://doi.org/10.3390/molecules181013061 PMid:24152676 Search in Google Scholar

16 Mammesier E, Aude S, Olive D. Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity. J Clin Investig. 2011;121(9):3609-22. https://doi.org/10.1172/JCI45816 PMid:21841316 Search in Google Scholar

17 Issacs JT. New strageties for the medical treatment of prostate cancer. BJU Internat. 2010;96(Suppl 2):35-40. https://doi.org/10.1111/j.1464-410X.2005.05945.x PMid:16359437 Search in Google Scholar

18 Curry EA 3^rd, Murry DJ, Yoder C, Fife K, Armstrong V, Nakshatri H, et al. Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer. Invest New Drugs. 2004;22(3):299-305. https://doi.org/10.1023/B: DRUG.0000026256.38560.be PMid:15122077 Search in Google Scholar

19 Picmann AK. Biological activities of sesquiterpene lactones. Biochem Systemat Ecol. 1986;14(3):255-81. https://doi.org/10.1016/0305-1978(86)90101-8 Search in Google Scholar

20 Koch E, Klaas CA, Rungeler P, Castro V, Mora G, Vichnewski W, et al. Inhibition of inflammatory cytokine production and lymphocyte proliferation by structurally different sesquiterpene lactones correlates with their effect on activation of NF-kappaB. Biochem Pharmacol. 2001;62(6):795-801. https://doi.org/10.1016/s0006-2952(01)00714-6 PMid:11551526 Search in Google Scholar

21 Dirsch VM, Stuppner H, Ellmerer-Muller EP, Vollmar AM. Structural requirements of sesquiterpene lactones to inhibit LPS-induced nitric oxide synthesis in RAW 264.7 macrophages. Bioorg Med Chem. 2000;8(12):2747-53. https://doi.org/10.1016/s0968-0896(00)00202-9 PMid:11131166 Search in Google Scholar