<abstract xmlns="http://www.w3.org/1999/xhtml">
<sec><h3>AIM:</h3>
<p>This study aimed to perform a systematic review (SR) of SR to elucidate prior findings regarding favorable outcomes between platelet-rich plasma (PRP) and hyaluronic acid (HA) injections for early knee osteoarthritis (KOA).</p>
</sec>
<sec><h3>MATERIALS AND METHODS: </h3>
<p>We conducted a thorough literature search adhering to the Preferred Reporting Items for SR and Meta-analyses only for SRs from PubMed, ScienceDirect, and Google Scholar from 2020 to 2023. The inclusion and exclusion criteria were determined using the population, intervention, comparison, outcome, and study design model. A measurement tool to assess SR-2 was used to grade the included SRs. Two researchers independently searched, extracted, and assessed the risk of bias in the included studies. Cohen’s kappa coefficient was used to calculate the inter-observer disparities in study eligibility and risk of bias. The corrected covered area (CCA) metric addressed the overlap issue with the original studies.</p>
</sec>
<sec><h3>RESULTS: </h3>
<p>One SR yielded high methodological quality whereas three SRs yielded moderate methodological quality. The overall CCA among the four SRs was 30.77%, and all SRs used the Western Ontario and McMaster Universities Osteoarthritis Index score as a patient-reported outcome (PRO) and revealed that the PRP group improved more than the HA group. One SR used the Tegner score as a PRO and found no distinction between the PRP and HA groups. The incidence of substantial pain was lower in the PRP group than in the HA group. One SR reported considerably lower local pain post-injection in the HA groups. Overall, three SRs showed that PRP yielded better outcomes than the HA, and one showed that PRP showed advantages over HA injections for knee pain at 6 and 12 months; however, the clinical outcomes were not different.</p>
</sec>
<sec><h3>CONCLUSION: </h3>
<p>Our findings supported the superiority of PRP over HA as a long-term alternative therapy for early-stage KOA.</p>
</sec>
</abstract>

AIM:
This study aimed to perform a systematic review (SR) of SR to elucidate prior findings regarding favorable outcomes between platelet-rich plasma (PRP) and hyaluronic acid (HA) injections for early knee osteoarthritis (KOA).

MATERIALS AND METHODS: 
We conducted a thorough literature search adhering to the Preferred Reporting Items for SR and Meta-analyses only for SRs from PubMed, ScienceDirect, and Google Scholar from 2020 to 2023. The inclusion and exclusion criteria were determined using the population, intervention, comparison, outcome, and study design model. A measurement tool to assess SR-2 was used to grade the included SRs. Two researchers independently searched, extracted, and assessed the risk of bias in the included studies. Cohen’s kappa coefficient was used to calculate the inter-observer disparities in study eligibility and risk of bias. The corrected covered area (CCA) metric addressed the overlap issue with the original studies.

RESULTS: 
One SR yielded high methodological quality whereas three SRs yielded moderate methodological quality. The overall CCA among the four SRs was 30.77%, and all SRs used the Western Ontario and McMaster Universities Osteoarthritis Index score as a patient-reported outcome (PRO) and revealed that the PRP group improved more than the HA group. One SR used the Tegner score as a PRO and found no distinction between the PRP and HA groups. The incidence of substantial pain was lower in the PRP group than in the HA group. One SR reported considerably lower local pain post-injection in the HA groups. Overall, three SRs showed that PRP yielded better outcomes than the HA, and one showed that PRP showed advantages over HA injections for knee pain at 6 and 12 months; however, the clinical outcomes were not different.

CONCLUSION: 
Our findings supported the superiority of PRP over HA as a long-term alternative therapy for early-stage KOA.

Platelet-rich Plasma Superiority over Hyaluronic Acid as a Conservative Treatment for Early Knee Osteoarthritis: A Systematic Review

Department of  Orthopaedics and Traumatology

Widya Mandala Catholic University, Faculty of Medicine

Department of Orthopaedics and Traumatology

Pelita Harapan University, Faculty of Medicine

Open Access Macedonian Journal of Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

AIM:
This study aimed to perform a systematic review (SR) of SR to elucidate prior findings regarding favorable outcomes between platelet-rich plasma (PRP) and...

Platelet-rich Plasma Superiority over Hyaluronic Acid as a Conservative Treatment for Early Knee Osteoarthritis: A Systematic Review

Publié en ligne: 16 mars 2024

Pages: 156 - 164

Reçu: 10 janv. 2024

Accepté: 30 janv. 2024

DOI: https://doi.org/10.3889/oamjms.2024.11860

Mots clés
Platelet-rich plasma, Hyaluronic acid, Knee osteoarthritis, Conservative treatment

© 2024 Gian Ivander et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Platelet-rich Plasma Superiority over Hyaluronic Acid as a Conservative Treatment for Early Knee Osteoarthritis: A Systematic Review

Publié en ligne: 16 mars 2024

Pages: 156 - 164

Reçu: 10 janv. 2024

Accepté: 30 janv. 2024

DOI: https://doi.org/10.3889/oamjms.2024.11860

Mots clésPlatelet-rich plasma, Hyaluronic acid, Knee osteoarthritis, Conservative treatment

© 2024 Gian Ivander et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Mots clés
Platelet-rich plasma, Hyaluronic acid, Knee osteoarthritis, Conservative treatment