Assessment Measures of an Ensemble Classifier Based on the Distributivity Equation to Predict the Presence of Severe Coronary Artery Disease

The aim of this study is to apply and evaluate the usefulness of the hybrid classifier to predict the presence of serious coronary artery disease based on clinical data and 24-hour Holter ECG monitoring. Our approach relies on an ensemble classifier applying the distributivity equation aggregating base classifiers accordingly. Such a method may be helpful for physicians in the management of patients with coronary artery disease, in particular in the face of limited access to invasive diagnostic tests, i.e., coronary angiography, or in the case of contraindications to its performance. The paper includes results of experiments performed on medical data obtained from the Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland. The data set contains clinical data, data from Holter ECG (24-hour ECG monitoring), and coronary angiography. A leave-one-out cross-validation technique is used for the performance evaluation of the classifiers on a data set using the WEKA (Waikato Environment for Knowledge Analysis) tool. We present the results of comparing our hybrid algorithm created from aggregation with the distributive equation of selected classification algorithms (multilayer perceptron network, support vector machine, k-nearest neighbors, naïve Bayes, and random forests) with themselves on raw data.