<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Introduction</h3>
<p>Perinatal asphyxia, a leading cause of neonatal mortality and neurological sequelae, necessitates early detection of pathophysiological neurologic changes during hypoxic-ischaemic encephalopathy (HIE). This study aimed to review published data on rScO2 monitoring during hypothermia treatment in neonates with perinatal asphyxia to predict short- and long-term neurological injury.</p>
</sec>
<sec><h3>Methods</h3>
<p>A systematic review was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Study identification was performed through a search between November and December 2021 in the electronic databases PubMed, Embase, Lilacs, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials (CENTRAL). The main outcome was short-term (Changes in brain magnetic resonating imaging) and long-term (In neurodevelopment) neurological injury. The study protocol was registered in PROSPERO (International Prospective Register of Systematic Reviews) with CRD42023395438.</p>
</sec>
<sec><h3>Results</h3>
<p>380 articles were collected from databases in the initial search. Finally, 15 articles were selected for extraction and analysis of the information. An increase in rScO2 measured by NIRS (Near-infrared spectroscopy) at different moments of treatment predicts neurological injury. However, there exists a wide variability in the methods and outcomes of the studies.</p>
</sec>
<sec><h3>Conclusion</h3>
<p>High rScO2 values were found to predict negative outcomes, with substantial discord among studies. NIRS is proposed as a real-time bedside tool for predicting brain injury in neonates with moderate to severe HIE.</p>
</sec>
</abstract>

Introduction
Perinatal asphyxia, a leading cause of neonatal mortality and neurological sequelae, necessitates early detection of pathophysiological neurologic changes during hypoxic-ischaemic encephalopathy (HIE). This study aimed to review published data on rScO2 monitoring during hypothermia treatment in neonates with perinatal asphyxia to predict short- and long-term neurological injury.

Methods
A systematic review was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Study identification was performed through a search between November and December 2021 in the electronic databases PubMed, Embase, Lilacs, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials (CENTRAL). The main outcome was short-term (Changes in brain magnetic resonating imaging) and long-term (In neurodevelopment) neurological injury. The study protocol was registered in PROSPERO (International Prospective Register of Systematic Reviews) with CRD42023395438.

Results
380 articles were collected from databases in the initial search. Finally, 15 articles were selected for extraction and analysis of the information. An increase in rScO2 measured by NIRS (Near-infrared spectroscopy) at different moments of treatment predicts neurological injury. However, there exists a wide variability in the methods and outcomes of the studies.

Conclusion
High rScO2 values were found to predict negative outcomes, with substantial discord among studies. NIRS is proposed as a real-time bedside tool for predicting brain injury in neonates with moderate to severe HIE.

Cerebral rScO2 Measured by Near-Infrared Spectroscopy (NIRS) During Therapeutic Hypothermia in Neonates with Hypoxic-Ischemic Encephalopathy: A Systematic Review

Deparment of Pediatrics, School of Medicine

Universidad de La Sabana. Campus Puente del Común

Pediatric Neonatologist. Head Neonatal Unit

Fundación Cardioinfantil - Instituto de Cardiología

Department of Bioscience. School of Medicine

Journal of Mother and Child

This work is licensed under the Creative Commons Attribution 4.0 International License.

Introduction
Perinatal asphyxia, a leading cause of neonatal mortality and neurological sequelae, necessitates early detection of pathophysiological neurologic...

Cerebral rScO2 Measured by Near-Infrared Spectroscopy (NIRS) During Therapeutic Hypothermia in Neonates with Hypoxic-Ischemic Encephalopathy: A Systematic Review

Article Category: Review

Publié en ligne: 19 avr. 2024

Pages: 33 - 44

Reçu: 05 févr. 2024

Accepté: 06 mars 2024

DOI: https://doi.org/10.34763/jmotherandchild.20242801.d-24-00010

Mots clés
Newborn, Hypoxic-ischemic encephalopathy, Asphyxia, Hypothermia Therapeutic, Spectroscopy Near-Infrared

© 2024 Sergio Agudelo-Pérez et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Cerebral rScO2 Measured by Near-Infrared Spectroscopy (NIRS) During Therapeutic Hypothermia in Neonates with Hypoxic-Ischemic Encephalopathy: A Systematic Review

Article Category: Review

Publié en ligne: 19 avr. 2024

Pages: 33 - 44

Reçu: 05 févr. 2024

Accepté: 06 mars 2024

DOI: https://doi.org/10.34763/jmotherandchild.20242801.d-24-00010

Mots clésNewborn, Hypoxic-ischemic encephalopathy, Asphyxia, Hypothermia Therapeutic, Spectroscopy Near-Infrared

© 2024 Sergio Agudelo-Pérez et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Mots clés
Newborn, Hypoxic-ischemic encephalopathy, Asphyxia, Hypothermia Therapeutic, Spectroscopy Near-Infrared