<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Aim</h3>
<p>To analyse placental changes in infants’ gestational age &lt; 34 weeks and its correlation to short-term respiratory outcomes or death until hospital discharge.</p>
</sec>
<sec><h3>Material and methods</h3>
<p>Information regarding all in-house born preterm infants born before 34 weeks gestation and born from January 2009 until December 2014 were collected and included among others, placental pathology and relevant data on demographics and outcomes of infants.</p>
</sec>
<sec><h3>Results</h3>
<p>Placental abnormalities was found in 157/253 (65.05%) cases. Acute placental inflammation was found to be the most common in both groups of premature neonates, followed by maternal vascular underperfusion. Maternal vascular underperfusion was significantly more common in GA ≤ 27 weeks compared to infants GA 28–33 weeks (35.2% vs. 13.7%; p = 0.018). Similarly, chronic placental inflammation was more common in infants GA ≤ 27 weeks compared to infants GA 28–33 weeks (14.3% vs. 3.3%; p = 0.014). Infants with placental pathology had a lower median birth weight (1460g vs. 1754g; p = 0.001, and were of shorter median GA at birth (31 vs. 32; p = 0.001). Infants with any placental disease had higher rates of death until hospital discharge (10.2% vs. 3.1%; p = 0.039) and higher rates of any stage of bronchopulmonary dysplasia (41.4% vs. 26.0%; p = 0.013). There were no significant differences in mechanical ventilation rates, duration of mechanical ventilation and duration of supplemental oxygen therapy.</p>
</sec>
<sec><h3>Conclusion</h3>
<p>Identifiable placental abnormalities were found in most infants born &lt; 34 weeks gestation. Placental pathology is associated with increased rates of bronchopulmonary dysplasia and death until hospital discharge.</p>
</sec>
</abstract>

Aim
To analyse placental changes in infants’ gestational age < 34 weeks and its correlation to short-term respiratory outcomes or death until hospital discharge.

Material and methods
Information regarding all in-house born preterm infants born before 34 weeks gestation and born from January 2009 until December 2014 were collected and included among others, placental pathology and relevant data on demographics and outcomes of infants.

Results
Placental abnormalities was found in 157/253 (65.05%) cases. Acute placental inflammation was found to be the most common in both groups of premature neonates, followed by maternal vascular underperfusion. Maternal vascular underperfusion was significantly more common in GA ≤ 27 weeks compared to infants GA 28–33 weeks (35.2% vs. 13.7%; p = 0.018). Similarly, chronic placental inflammation was more common in infants GA ≤ 27 weeks compared to infants GA 28–33 weeks (14.3% vs. 3.3%; p = 0.014). Infants with placental pathology had a lower median birth weight (1460g vs. 1754g; p = 0.001, and were of shorter median GA at birth (31 vs. 32; p = 0.001). Infants with any placental disease had higher rates of death until hospital discharge (10.2% vs. 3.1%; p = 0.039) and higher rates of any stage of bronchopulmonary dysplasia (41.4% vs. 26.0%; p = 0.013). There were no significant differences in mechanical ventilation rates, duration of mechanical ventilation and duration of supplemental oxygen therapy.

Conclusion
Identifiable placental abnormalities were found in most infants born < 34 weeks gestation. Placental pathology is associated with increased rates of bronchopulmonary dysplasia and death until hospital discharge.

Placental Findings in Infants Gestational Age &lt; 34 Weeks and Impact on Short-Term Outcomes

Clinical Institute for Pathology and Forensic Medicine

Neonatal Intensive Care Unit, Department of Pediatrics

Journal of Mother and Child

This work is licensed under the Creative Commons Attribution 4.0 International License.

Placental Findings in Infants Gestational Age < 34 Weeks and Impact on Short-Term Outcomes

Aim
To analyse placental changes in infants’ gestational age < 34 weeks and its correlation to short-term respiratory outcomes or death until hospital...

Placental Findings in Infants Gestational Age < 34 Weeks and Impact on Short-Term Outcomes

Article Category: Original Research

Publié en ligne: 03 nov. 2023

Pages: 168 - 175

Reçu: 26 janv. 2023

Accepté: 29 sept. 2023

DOI: https://doi.org/10.34763/jmotherandchild.20222601.d-23-00017

Mots clés
placenta, death until discharge, premature neonates, bronchopulmonary dysplasia, oxygen therapy, neonatal

© 2023 Krešimir Šantić et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Placental Findings in Infants Gestational Age < 34 Weeks and Impact on Short-Term Outcomes

Article Category: Original Research

Publié en ligne: 03 nov. 2023

Pages: 168 - 175

Reçu: 26 janv. 2023

Accepté: 29 sept. 2023

DOI: https://doi.org/10.34763/jmotherandchild.20222601.d-23-00017

Mots clésplacenta, death until discharge, premature neonates, bronchopulmonary dysplasia, oxygen therapy, neonatal

© 2023 Krešimir Šantić et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Mots clés
placenta, death until discharge, premature neonates, bronchopulmonary dysplasia, oxygen therapy, neonatal