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Accuracy of the mothers’ information answers aboutnonprescribed medications (N = 377) use during breastfeeding

The mothers’ information about nonprescribed medications during breastfeeding Frequency (%)
The accuracy of the mothers’ Accurate 212 (56.2%)
information about the side effects information
of nonprescribed medications Inaccurate 131 (34.7%)
information
The mothers 14 (3.7%)
did not have
any information
Not enough 20 (5.3%)
data available
The accuracy of the mothers’ Accurate 278 (73.7%)
information about routine breast- information
feeding while taking nonprescribed medications Inaccurate information 73 (19.4%)
Not enough 26 (6.9%)
data available
The accuracy of the mothers’ Accurate 261 (69.2%)
information about secretion of information
nonprescribed medications into breast milk Inaccurate information 31 (8.2%)
The mothers 41 (10.9%)
did not have any
information
Not enough 44 (11.7%)
data available

Nonprescribed medications classification based on the Anatomical Therapeutic Chemical classification system (N = 377)

Anatomical Therapeutic Chemical classification system Frequency (%)
Alimentary tract and metabolism 45 (11.9%)
Blood and blood-forming organs 14 (3.7%)
Cardiovascular system 2 (0.5%)
Genito-urinary system and sex hormones 34 (9.0%)
Anti-infectives for systemic use 53 (14.1%)
Musculoskeletal system 32 (8.5%)
Nervous system 173 (45.9%)
Anti-parasitic products, insecticides, and repellents 4 (1.1%)
Respiratory system 19 (5.0%)
Sensory organs 1 (0.30%)
Total 377 (100%)

Nonprescribed medications use data (N = 377)

Drug use data Categories Frequency (%)
Source of drug Family members and friends 73 (19.3%)
information for self-medication Internet and online social media 12 (3.2%)
Pharmacy staff 153 (40.6%)
Previous experiences 140 (37.1%)
Health centers 13 (3.4%)
Duration of the Less than one week 293 (77.7%)
nonprescribed medication use One week to one month 54 (14.3%)
More than one month 30 (8.0%)
Time of the drug The first six months after 225 (60.7%)
use during the delivery
18 months after delivery The second six months after delivery 194 (51.4%)
The third six months after 52 (13.7%)
delivery
Common indica- Digestive problems 9 (2.4%)
tions medication for self- Urinary problems 7 (1.9%)
Migraine and pain 141 (37.4%)
Problems with milk volume 23 (6.1%)
Respiratory problems 129 (34.2%)
Anaemia 15 (4.0%)
Tooth infection 14 (3.7%)
Abscesses and breast infec- 3 (0.8%)
tions
Uterine infection 6 (1.6%)
Other 30 (8.0%)

Reasons for using nonprescribed medications (N = 377)

Reasons Frequency (%)
COVID-19 outbreak 246 (65.3%)
Financial problems and cost saving 75 (19.9%)
Unseriousness of the disease from the mothers’ perspectives 114 (30.2%)
Consulting with close relatives who are physicians 14 (3.7%)
The mother or father is a physician or a therapist 16 (4.2%)
Absence of health insurance 4 (1.1%)
Consulting with health center staff and care providers 5 (1.3%)
Anti-parasitic products, insecticides, and repellents 4 (1.1%)
Poor health service provision due to living in a deprived area 1 (0.3%)
Easier access to a pharmacy than to a doctor 52 (13.8%)

Classification of nonprescribed medications (n = 377) during breastfeeding based on UptoDate Database, drug information leaflets, and Briggs

Classification Frequency (%)
Compatible 279 (74.0%)
No human data – probably compatible 61 (16.2%)
Breastfeeding is contraindicated by the manufacturer 18 (4.8%)
Limited human data – probably compatible 6 (1.6%)
Breastfeeding is allowed only upon the physician’s advice 1 (0.3%)
Breastfeeding is not recommended by the manufacturer 10 (2.7%)
Limited human data – potential toxicity 2 (0.5%)

Demographic characteristics of the participating mothers (n = 228), infants’ diets and daily breastfeeding patterns

Characteristics Frequency (%)
Routes of birth delivery
Caesarean section 119 (52.2%)
Vaginal delivery 109 (47.8%)
Mothers’ education
Illiterate 6 (2.6%)
Less than high school diploma 21 (9.2%)
High school diploma 89 (39.0%)
More than high school diploma 112 (49.2%)
Mothers’ jobs
Housewife 182 (79. 8%)
Employee 41 (18.0%)
University student 1 (0.4%)
Medical staff 4 (1.8%)
Fathers’ jobs
Unemployed 4 (1.8%)
Self-employed 155 (68.0%)
Employee 63 (27.6%)
University student 1 (0.4%)
Medical staff 5 (2.2%)
Income per month (dollar)
Less than 70 41 (18.0%)
70-170 134 (58.8%)
More than 170 53 (32.2%)
Infants’ diets
Exclusive breastfeeding 49 (21.5%)
Breastfeeding plus supplementary food 155 (68.0%)
Breastfeeding plus infant formula 8 (3.5%)
Breastfeeding plus infant formula plus 16 (7.0%)
supplementary food
Breastfeeding (times per day)
Less than 5 times 28 (12.3%)
5-10 times 119 (52.2%)
More than 10 times 81 (35.5%)

Questions and mothers’ answers about nonprescribed medications (N = 377) use during breastfeeding

Questions answers Frequency (%)
Did you read the drug information leaflet before using the non-prescribed Yes 118 (31.3%)
medication? No 259 (7/68%)
Did the drug have any effects on the Yes 74 (19.6%)
quality and quantity of your milk? No 292 (77.5%)
Did not notice 11 (2.9%)
Did you breastfeed as usual while Yes 363 (96.3%)
taking the nonprescribed medication? No 14 (3.7%)
Yes 286 (75.9%)
No 30 (8.0%)
Is the used drug secreted into breast milk? Do not know 61 (16.2%)
Is the drug use during lactation Yes 209 (55.4%)
permissible? No 28 (7.4%)
Do not know 140 (37.1%)
Does the used drug have adverse Yes 20 (5.3%)
effects on infants? No 343 (91.0%)
Do not know 14 (3.7%)