The retrospective molecular analysis of large or giant congenital melanocytic nevi in a group of Polish children Article Category: Original paper Publié en ligne: 11 oct. 2021 Pages: 19 - 24 Reçu: 07 mars 2021 Accepté: 22 avr. 2021 © 2021 Katarzyna Wertheim-Tysarowska et al. published by Sciendo This work is licensed under the Creative Commons Attribution 4.0 International License.
Figure 1 Examples of CMN: head localisation of the nevi (1, 2), anterior and posteriori view of neonate with bathing trunk localisation of the nevus before first operation (3, 4), neonate with back localisation of main nevus (5). Photographed by Marcin R. Szulżycki. Characteristics of patients and results of molecular investigation
Patient No
Year of birth/sex
Localization of nevus
Melanoma arising in the nevus
Neurocutaneous melanosis (NCM)
Age during first operation
Number of operations
Treatment completed
CMN size
Satellite nevi
BRAF variants detected
NRAS variants detected
1
2011/m
B
6/12
5
+
>20 cm
+
none
p.Gln61Lys
2
2012/m
H
+
7/12
4
> 0,5% PAS
0
none
none
3
2012/m
H
1/12
2
+
0,5 % PAS
0
none
p.Gln61Lys
4
2009/f
BT
4y
6
> 20 cm
++
none
none
5
1989/f
N
15y
4
+
> 20 cm
0
none
none
6
2003/f
B
1/12
5
+
> 20 cm
+
none
none
7
2007/f
BT
+
1/12
14
> 20 cm
0
none
none
8
2011/m
B
3/12
2
+
> 20 cm
0
none
p.Gln61Lys
9
2009/f
B
4/12
8
+
> 20 cm
+
none
none
10
2007/f
H
2y
8
> 0,5% PAS
+
none
p.Gln61Lys
11
2011/f
B
3/12
5
+
> 20 cm
+
none
p.Gly12Asp
12
2006/m
BT
+
4/12
21
> 20 cm
nd
none
none
13
2009/m
B
+
2y
5
> 20 cm
++
none
p.Gln61Lys
14
2002/m
BT
2y
10
+
not assessed
0
none
p.Gln61Arg
15
2012/m
HN
3/12
2
> 0,5% PAS
0
none
none
16
2010/f
B
+
6/12
4
+
> 20 cm
+
none
none
17
2006/f
BT
+
+
6/12
13
+
> 20 cm
nd
none
none
18
2008/m
H
+
+
1/12
3
+
> 0,5% PAS
-
none
none