Comparative Study of Linezolid and Vancomycin Regimens in One-Stage Surgery for Treating Limb Traumatic Osteomyelitis Caused by Methicillin-Resistant Staphylococcus aureus
, , , , , et | 20 sept. 2023
À propos de cet article
Article Category: Original Paper
Publié en ligne: 20 sept. 2023
Pages: 239 - 246
Reçu: 31 mars 2023
Accepté: 20 mai 2023
DOI: https://doi.org/10.33073/pjm-2023-024
Mots clés
© 2023 Rongchang Zhou et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Comparisons of inflammatory markers and renal function after the surgical operation.
| Group | Day after the surgery | WBC (×109) | ESR (mm/h) | CRP (mg/l) | BUN (mmol/l) | SCr (μmol/l) |
|---|---|---|---|---|---|---|
| Study group (n = 32) | 1 | 12.4 ± 2.3 | 92.3 ± 8.4 | 68.3 ± 6.8 | 4.7 ± 2.5 | 86.5 ± 13.7 |
| 7 | 8.9 ± 1.9 | 40.9 ± 5.4 | 29.5 ± 3.6 | 4.7 ± 2.5 | 84.3 ± 12.5 | |
| 16 | 5.8 ± 1.5 |
27.7 ± 4.7 |
14.3 ± 2.9 |
4.5 ± 2.4 |
79.4 ± 11.5 |
|
| Control group (n = 32) | 1 | 12.7 ± 2.4 | 97.4 ± 8.9 | 65.9 ± 6.4 | 4.9 ± 2.6 | 83.1 ± 13.2 |
| 7 | 9.1 ± 1.9 | 43.5 ± 5.5 | 32.2 ± 3.7 | 5.4 ± 2.8 | 91.8 ± 15.4 | |
| 16 | 8.8 ± 1.8 | 38.7 ± 5.0 | 24.9 ± 3.0 | 7.7 ± 3.7 | 122.8 ± 21.1 |
Comparisons of baseline characteristics between two group.
| Study group (n = 32) | Control group (n = 32) | ||
|---|---|---|---|
| Gender, n | |||
| Male | 21 | 18 | 0.644 |
| Age, M ± SD, year | 47.9 ± 6.4 | 48.8 ± 6.8 | 0.590 |
| Number of previous surgery, M ± SD | 2.2 ± 1.1 | 2.5 ± 1.2 | 0.476 |
| Disease duration, M ± SD, month | 15.5 ± 4.3 | 16.2 ± 4.7 | 0.532 |
| Site of infection, n | 0.315 | ||
| Tibia | 17 | 15 | |
| Femur | 5 | 4 | |
| Calcaneus | 10 | 13 | |
| Cause of injury, n | 0.276 | ||
| Fall | 14 | 17 | |
| Car accident | 6 | 4 | |
| Fall from height | 12 | 11 | |
| Type of fracture, n | 0.427 | ||
| Closed | 28 | 26 | |
| Open | 6 | 6 | |
| Internal fixation, n | 16 | 13 | 0.352 |
| Classification by Cierny-Mader criteria, n | 0.287 | ||
| Type I | 17 | 15 | |
| Type II | 3 | 5 | |
| Type III | 10 | 8 | |
| Type IV | 2 | 4 | |
Comparisons of adverse events between two groups.
| Group | Adverse events n (%) | Adjustment of antibiotic regimen n (%) |
|---|---|---|
| Study group (n = 32) | 2 (6.25) |
0 (0) |
| Control group (n = 32) | 5 (15.63) | 3 (9.38) |
Comparisons of clinical variables between two groups (mean ± standard deviation, day).
| Group | Duration of antibiotics | Duration of drainage tube | Length of hospital stay |
|---|---|---|---|
| Study group (n = 32) | 15.1 ± 2.5 | 24.5 ± 5.4 |
27.4 ± 4.4 |
| Control group (n = 32) | 14.9 ± 2.3 | 36.8 ± 7.3 | 36.3 ± 6.1 |