<abstract xmlns="http://www.w3.org/1999/xhtml"><p>This study aims to investigate trends in bloodstream infections and their antimicrobial susceptibility profiles over 12 years in our hospital. This retrospective study was carried out in the Bursa Uludag University Hospital, Turkey, during 2008–2019. Blood cultures from patients were performed using BACTEC System. Isolates were identified with Phoenix System until 2018 and “matrix-assisted laser desorption ionization time-of-flight mass spectrometry” (MALDI-TOF MS) in 2019. Antibiotic susceptibility testing was performed with Phoenix System. Patient data came from the BD EpiCenter™ data management system. <italic>Escherichia coli</italic> was found to be the most common Gram-negative (11.6%), and coagulase-negative staphylococci were the most common Gram-positive (10.1%) monomicrobial growth. Overall, there was a significant increase in rates of extended-spectrum β-lactamase positive <italic>E. coli</italic> (<italic>p</italic> = 0.014) and <italic>Klebsiella pneumonia</italic> (<italic>p</italic> &lt; 0.001), carbapenem-resistant <italic>E. coli</italic> (<italic>p</italic> &lt; 0.001), and <italic>K. pneumoniae</italic> (<italic>p</italic> &lt; 0.001) and colistin-resistant <italic>K. pneumoniae</italic> (<italic>p</italic> &lt; 0.001) and <italic>Acinetobacter baumannii</italic> (<italic>p</italic> &lt; 0.001) over 12 years. Carbapenem and colistin resistance has increased dramatically in recent years. We believe that regular monitoring of the distribution of pathogens and antibiotic susceptibility profiles, especially in intensive care units, can contribute to evidence for the increase in resistant microorganisms and help prevent their spread with antimicrobial stewardship and infection control policies.</p>
</abstract>

This study aims to investigate trends in bloodstream infections and their antimicrobial susceptibility profiles over 12 years in our hospital. This retrospective study was carried out in the Bursa Uludag University Hospital, Turkey, during 2008–2019. Blood cultures from patients were performed using BACTEC System. Isolates were identified with Phoenix System until 2018 and “matrix-assisted laser desorption ionization time-of-flight mass spectrometry” (MALDI-TOF MS) in 2019. Antibiotic susceptibility testing was performed with Phoenix System. Patient data came from the BD EpiCenter™ data management system. Escherichia coli was found to be the most common Gram-negative (11.6%), and coagulase-negative staphylococci were the most common Gram-positive (10.1%) monomicrobial growth. Overall, there was a significant increase in rates of extended-spectrum β-lactamase positive E. coli (p = 0.014) and Klebsiella pneumonia (p < 0.001), carbapenem-resistant E. coli (p < 0.001), and K. pneumoniae (p < 0.001) and colistin-resistant K. pneumoniae (p < 0.001) and Acinetobacter baumannii (p < 0.001) over 12 years. Carbapenem and colistin resistance has increased dramatically in recent years. We believe that regular monitoring of the distribution of pathogens and antibiotic susceptibility profiles, especially in intensive care units, can contribute to evidence for the increase in resistant microorganisms and help prevent their spread with antimicrobial stewardship and infection control policies.

Trends of Bloodstream Infections in a University Hospital During 12 Years

Polish Journal of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Trends of Bloodstream Infections in a University Hospital During 12 Years"}

This study aims to investigate trends in bloodstream infections and their antimicrobial susceptibility profiles over 12 years in our hospital. This...

Trends of Bloodstream Infections in a University Hospital During 12 Years

Article Category: Original Paper

Publié en ligne: 24 sept. 2022

Pages: 443 - 452

Reçu: 26 mai 2022

Accepté: 27 juil. 2022

DOI: https://doi.org/10.33073/pjm-2022-039

Mots clés
bloodstream infections, antimicrobial resistance, blood culture

© 2022 Nazmiye Ülkü Tüzemen et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Trends of Bloodstream Infections in a University Hospital During 12 Years

Article Category: Original Paper

Publié en ligne: 24 sept. 2022

Pages: 443 - 452

Reçu: 26 mai 2022

Accepté: 27 juil. 2022

DOI: https://doi.org/10.33073/pjm-2022-039

Mots clésbloodstream infections, antimicrobial resistance, blood culture

© 2022 Nazmiye Ülkü Tüzemen et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
bloodstream infections, antimicrobial resistance, blood culture