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Polish Journal of Microbiology
Édition 71 (2022): Edition 2 (June 2022)
Accès libre
Oral Microbiota, a Potential Determinant for the Treatment Efficacy of Gastric
Helicobacter pylori
Eradication in Humans
Huixia Chen
Huixia Chen
,
Hui Xie
Hui Xie
,
Dong Shao
Dong Shao
,
Liju Chen
Liju Chen
,
Siyu Chen
Siyu Chen
,
Lin Wang
Lin Wang
et
Xiao Han
Xiao Han
| 31 mai 2022
Polish Journal of Microbiology
Édition 71 (2022): Edition 2 (June 2022)
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Article Category:
Original Paper
Publié en ligne:
31 mai 2022
Pages:
227 - 239
Reçu:
05 janv. 2022
Accepté:
22 mars 2022
DOI:
https://doi.org/10.33073/pjm-2022-020
Mots clés
eradication
,
therapeutic effects
,
oral microbiota
,
sequencing
© 2022 Huixia Chen et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Fig. 1
Sample collection and qualification of 16S rRNA sequencing.A) A schematic diagram illustrating the sample collection process; B) rarefaction curve analysis; C) specaccum curve analyses; D) rank abundance analysis; n = 7 for the SE group, n = 9 for the FE group; FE – failure eradication, SE – successful eradication, HP – Helicobacter pylori.
Fig. 2
α and β Diversity analyses.A) Observed species, Chao1 richness, ACE index, Shannon index, Simpson index, and J index were calculated for α diversity of the oral microbiota.
Fig. 2
α and β Diversity analyses.B) PCoA analysis for β diversity of the oral microbiota; SE – patients with successful eradication therapy, FE – patients with failed eradication therapy.
Fig. 3
Component analysis of community structure.A) Relative abundances of the ten most abundant bacterial phyla in the FE and SE groups; B) relative abundances of the indicated individuals’ ten most abundant bacterial phyla; C) t-test analysis comparing oral microbiota composition between the FE and SE groups.
Fig. 3
Component analysis of community structure.D) cladogram generated from LEfSe analysis.
Fig. 3
Component analysis of community structure.E) LDA scores of significantly altered taxa presented in panel D; n = 7 for the SE group, n = 9 for the FE group; SE – patients with successful eradication therapy, FE – patients with failed eradication therapy.
Fig. 4
Correlation analysis of microbial environmental factors.A) RDA analysis comparing OTUs between the FE and SE groups.
Fig. 4
Correlation analysis of microbial environmental factors.E) KEGG analysis diagram; n = 7 for the SE group, n = 9 for the FE group; SE – patients with successful eradication therapy, FE – patients with failed eradication therapy.
Fig. 4
Correlation analysis of microbial environmental factors.B) heat map analysis based on RDA analysis showing the abundance of 14 OTUs influenced by Helicobacter pylori infection.
Fig. 4
Correlation analysis of microbial environmental factors.C) correlations of the abundances of 14 OTUs with DOB values, ages, sex, and treatment status in patients from either FE or SE groups;*p < 0.05, **p < 0.01; PICRUSt2 function prediction of changed OTUs; D) PCA analysis.
Fig. 5
Venn analysis revealing differently affected and overlapping OTUs between the FE and SE groups; n = 7 for the SE group, n = 9 for the FE group; SE – patients with successful eradication therapy, FE – patients with failed eradication therapy.
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