Strains | FICI |
---|---|
MRSA14 | 0.63 |
MRSA15 | 0.75 |
MRSA16 | 0.38 |
MRSA20 | 0.31 |
MRSA21 | 0.31 |
MRSA22 | 2.25 |
MRSA25 | 0.53 |
MRSA29 | 2.13 |
MRSA30 | 0.26 |
MRSA64 | 0.14 |
MRSA65 | 0.26 |
MRSA75 | 1.00 |
MRSA76 | 1.13 |
MRSA92 | 0.26 |
MRSA94 | 0.51 |
MRSA97 | 0.52 |
MRSA98 | 0.26 |
MRSA125 | 0.50 |
MRSA126 | 1.50 |
MRSA134 | 1.50 |
MRSA135 | 0.27 |
MRSA142 | 1.01 |
MRSA162 | 0.63 |
ATCC 29213 | 0.50 |
MSSA10 | 0.56 |
MSSA13 | 0.31 |
MSSA14 | 2.00 |
MSSA31 | 1.13 |
MSSA36 | 2.02 |
MSSA41 | 1.50 |
MSSA42 | 0.27 |
MSSA44 | 1.06 |
MSSA50 | 1.03 |
MSSA51 | 1.00 |
MSSA54 | 1.50 |
MSSA56 | 1.00 |
MSSA62 | 1.50 |
MSSA65 | 1.03 |
MSSA66 | 0.53 |
MSSA67 | 0.31 |
MSSA68 | 0.53 |
MSSA70 | 0.52 |
MSSA72 | 0.28 |
MSSA73 | 1.03 |
MSSA78 | 1.06 |
MSSA79 | 0.56 |
MSSA80 | 0.56 |
MRSA | (methicillin-resistant |
TZ | (thioridazine); |
MCZ | (miconazole); |
CXN | (cloxacillin); |
MIC | (the minimum inhibitory concentration); |
TNF-α | (tumor necrosis factor-α); |
IL-1β | (interleukin 1β); |
IL-6 | (interleukin 6); |
IĸB | (K-B inhibitor); |
NF-KB | (nuclear factor K-B); |
CTCC | (the China Type Culture Collection); |
ATCC | (American Type Culture Collection); |
FIC | (the fractional inhibitory concentration). |
Strain | FICI |
---|---|
MRSA14 | 0.38 |
MRSA15 | 0.63 |
MRSA16 | 0.75 |
MRSA20 | 0.25 |
MRSA21 | 0.50 |
MRSA22 | 0.63 |
MRSA25 | 0.31 |
MRSA29 | 0.19 |
MRSA30 | 1.06 |
MRSA64 | 0.25 |
MRSA65 | 0.25 |
MRSA75 | 1.13 |
MRSA76 | 1.13 |
MRSA92 | 0.31 |
MRSA94 | 0.19 |
MRSA97 | 0.25 |
MRSA98 | 0.19 |
MRSA125 | 0.27 |
MRSA126 | 0.50 |
MRSA134 | 0.16 |
MRSA135 | 0.16 |
MRSA142 | 0.63 |
MRSA162 | 0.38 |
ATCC 29213 | 0.28 |
MSSA10 | 0.31 |
MSSA13 | 0.56 |
MSSA14 | 0.63 |
MSSA31 | 0.63 |
MSSA36 | 0.38 |
MSSA41 | 0.63 |
MSSA42 | 0.56 |
MSSA44 | 0.38 |
MSSA50 | 0.38 |
MSSA51 | 0.14 |
MSSA54 | 0.38 |
MSSA56 | 0.63 |
MSSA62 | 0.63 |
MSSA65 | 0.63 |
MSSA66 | 1.13 |
MSSA67 | 1.13 |
MSSA68 | 1.13 |
MSSA70 | 1.13 |
MSSA72 | 1.06 |
MSSA73 | 0.63 |
MSSA78 | 1.25 |
MSSA79 | 1.25 |
MSSA80 | 0.25 |
Antimicrobial agents | MIC (μg/ml) | ||
---|---|---|---|
Range | 50% | 90% | |
Cloxacillin | 4–512 | 16 | 512 |
Thioridazine | 16–64 | 32 | 64 |
Miconazole | 1–8 | 4 | 8 |
Antimicrobial agents | MIC (μg/ml) | |||
---|---|---|---|---|
Range | 50% | 90% | ||
Cloxacillin | Thioridazine | 0.125–512 | 16 | 512 |
Miconazole | 0.25–512 | 4 | 512 | |
Thioridazine + Miconazole | 0.000972–16 | 0.5 | 8 |
Strain | CXN | TZ | MCZ | CXN | TZ | MCZ | FICI |
---|---|---|---|---|---|---|---|
MICs (Single) | MICs (Synergy) | ||||||
MRSA14 | 512 | 32 | 2 | 4 | 4 | 0.25 | 0.26 |
MRSA15 | 512 | 32 | 2 | 2 | 4 | 0.25 | 0.25 |
MRSA16 | 512 | 16 | 4 | 1 | 4 | 0.25 | 0.31 |
MRSA20 | 256 | 32 | 2 | 0.25 | 4 | 0.25 | 0.25 |
MRSA21 | 128 | 16 | 4 | 0.5 | 4 | 0.25 | 0.32 |
MRSA22 | 64 | 32 | 4 | 0.25 | 4 | 0.50 | 0.25 |
MRSA25 | 512 | 16 | 2 | 0.5 | 4 | 0.50 | 0.50 |
MRSA29 | 256 | 64 | 4 | 4 | 4 | 0.50 | 0.20 |
MRSA30 | 512 | 64 | 4 | 0.5 | 4 | 0.50 | 0.19 |
MRSA64 | 512 | 32 | 8 | 8 | 4 | 0.50 | 0.20 |
MRSA65 | 512 | 32 | 4 | 0.5 | 4 | 0.50 | 0.25 |
MRSA75 | 512 | 32 | 2 | 0.5 | 4 | 0.50 | 0.38 |
MRSA76 | 512 | 32 | 4 | 8 | 4 | 0.50 | 0.27 |
MRSA92 | 512 | 16 | 4 | 0.0078 | 4 | 0.50 | 0.38 |
MRSA94 | 512 | 32 | 2 | 0.0078 | 4 | 0.50 | 0.38 |
MRSA97 | 256 | 32 | 2 | 0.0156 | 4 | 0.50 | 0.38 |
MRSA98 | 512 | 32 | 4 | 0.0078 | 4 | 0.50 | 0.25 |
MRSA125 | 256 | 16 | 2 | 0.5 | 4 | 0.50 | 0.50 |
MRSA126 | 256 | 16 | 1 | 1 | 4 | 0.50 | 0.75 |
MRSA134 | 512 | 32 | 1 | 0.0078 | 4 | 0.50 | 0.63 |
MRSA135 | 256 | 32 | 4 | 0.25 | 4 | 0.50 | 0.25 |
MRSA142 | 512 | 32 | 1 | 2 | 4 | 0.50 | 0.63 |
MRSA162 | 512 | 32 | 4 | 16 | 4 | 0.50 | 0.28 |
ATCC 29213 | 4 | 16 | 4 | 0.0156 | 4 | 0.50 | 0.38 |
Strain | CXN | TZ | MCZ | CXN | TZ | MCZ | FICI |
---|---|---|---|---|---|---|---|
MICs (Single) | MICs (Synergy) | ||||||
MSSA10 | 16 | 64 | 4 | 4 | 4 | 0.25 | 0.38 |
MSSA13 | 8 | 64 | 8 | 8 | 4 | 0.25 | 1.09 |
MSSA14 | 8 | 32 | 2 | 8 | 4 | 0.25 | 1.25 |
MSSA31 | 16 | 32 | 2 | 4 | 4 | 0.25 | 0.50 |
MSSA36 | 16 | 32 | 1 | 0.015625 | 4 | 0.25 | 0.38 |
MSSA41 | 8 | 32 | 1 | 4 | 4 | 0.25 | 0.88 |
MSSA42 | 16 | 64 | 8 | 0.125 | 4 | 0.25 | 0.10 |
MSSA44 | 16 | 32 | 1 | 0.5 | 4 | 0.25 | 0.41 |
MSSA50 | 16 | 32 | 1 | 0.125 | 4 | 0.25 | 0.38 |
MSSA51 | 16 | 32 | 2 | 0.001975 | 4 | 0.25 | 0.25 |
MSSA54 | 16 | 16 | 2 | 0.0625 | 4 | 0.25 | 0.38 |
MSSA56 | 16 | 32 | 2 | 0.03125 | 4 | 0.25 | 0.25 |
MSSA62 | 16 | 32 | 2 | 0.0009715 | 4 | 0.25 | 0.25 |
MSSA65 | 16 | 32 | 2 | 0.125 | 4 | 0.25 | 0.26 |
MSSA66 | 16 | 32 | 4 | 4 | 4 | 0.25 | 0.44 |
MSSA67 | 16 | 32 | 4 | 8 | 4 | 0.25 | 0.69 |
MSSA68 | 16 | 32 | 4 | 16 | 4 | 0.25 | 1.19 |
MSSA70 | 16 | 32 | 4 | 0.015625 | 4 | 0.25 | 0.19 |
MSSA72 | 16 | 64 | 8 | 0.5 | 4 | 0.25 | 0.13 |
MSSA73 | 16 | 32 | 2 | 0.0625 | 4 | 0.25 | 0.25 |
MSSA78 | 8 | 16 | 2 | 0.03125 | 4 | 0.25 | 0.38 |
MSSA79 | 8 | 16 | 4 | 0.03125 | 4 | 0.25 | 0.32 |
MSSA80 | 16 | 32 | 4 | 0.0078125 | 4 | 0.25 | 0.19 |
ATCC 29213 | 4 | 16 | 4 | 0.0156 | 4 | 0.50 | 0.38 |