<abstract xmlns="http://www.w3.org/1999/xhtml"><p> In a retrospective study, the safety profile and efficacy of immunosuppressive medication was evaluated in 35 patients with cardiac transplant in Targu Mures during 1999-2011 (11 treated with cyclosporine, 24 with tacrolimus, both drugs were associated with mycophenolate mofetil). Therapeutic benefit was measured by survival curve and lack of rejection while safety was evaluated by measuring plasma immunosuppressive drugs levels and evaluation of specific adverse events (nephrotoxicity, diabetes, and hypertension). The most frequent side effect was nephrotoxicity (significant reduction in glomerular filtration rate estimated by MDRD formula), but no significant differences were found between the 2 medications.</p></abstract>

In a retrospective study, the safety profile and efficacy of immunosuppressive medication was evaluated in 35 patients with cardiac transplant in Targu Mures during 1999-2011 (11 treated with cyclosporine, 24 with tacrolimus, both drugs were associated with mycophenolate mofetil). Therapeutic benefit was measured by survival curve and lack of rejection while safety was evaluated by measuring plasma immunosuppressive drugs levels and evaluation of specific adverse events (nephrotoxicity, diabetes, and hypertension). The most frequent side effect was nephrotoxicity (significant reduction in glomerular filtration rate estimated by MDRD formula), but no significant differences were found between the 2 medications.

Immunosuppressant medication in cardiac transplant patients - between therapeutic benefit and iatrogenic pathology

Pharmacology and Clinical Pharmacy Department

Institute of Cardiovascular Diseases and Transplantation Târgu Mureş

Drug analysis Department, University of Medicine and Pharmacy Târgu Mureş

ARS Medica Tomitana

In a retrospective study, the safety profile and efficacy of immunosuppressive medication was evaluated in 35 patients with cardiac transplant in Targu Mures...

Immunosuppressant medication in cardiac transplant patients - between therapeutic benefit and iatrogenic pathology

Publié en ligne: 13 mars 2013

Pages: 101 - 111

DOI: https://doi.org/10.2478/v10307-012-0021-y

Mots clés
cyclosporine, tacrolimus, side effects, heart transplant

This content is open access.

Immunosuppressant medication in cardiac transplant patients - between therapeutic benefit and iatrogenic pathology

Publié en ligne: 13 mars 2013

Pages: 101 - 111

DOI: https://doi.org/10.2478/v10307-012-0021-y

Mots cléscyclosporine, tacrolimus, side effects, heart transplant

This content is open access.

Mots clés
cyclosporine, tacrolimus, side effects, heart transplant