<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Peutz-Jegher’s syndrome is a hereditary disorder characterized by melanocytic macules on the lips and buccal mucosa and multiple gastrointestinal hamartomatous polyps. It is caused by a mutation localized on chromosome 19p13.3. Skin and mucosal pigmentation may be present at birth and usually occur in early childhood, but occasionally may develop later. It is associated with an increased risk of malignancy for gastrointestinal carcinoma and also for breast, ovarian, testiscular, pancreatic and gallbladder cancer. We report a 12-year-old girl who presented with disseminated petty yellowish macules on the bridge of her nose, numerous brown to bluish black macules on her lips and buccal mucosa. Mucocutaneous pigmentation has been present from the age of five, with a negative family history. In our patient, esophageal endoscopy was normal, while the endoscopy of stomach and duodenum revealed multiple diminutive polyps. After clinical evaluation, there were no indications for therapy. Further follow up was suggested. Continuous surveillance is very important for patients with Peutz-Jegher’s syndrome in order to reduce risks of cancer and prevent other morbidity and mortality.</p></abstract>

Peutz-Jegher’s syndrome is a hereditary disorder characterized by melanocytic macules on the lips and buccal mucosa and multiple gastrointestinal hamartomatous polyps. It is caused by a mutation localized on chromosome 19p13.3. Skin and mucosal pigmentation may be present at birth and usually occur in early childhood, but occasionally may develop later. It is associated with an increased risk of malignancy for gastrointestinal carcinoma and also for breast, ovarian, testiscular, pancreatic and gallbladder cancer. We report a 12-year-old girl who presented with disseminated petty yellowish macules on the bridge of her nose, numerous brown to bluish black macules on her lips and buccal mucosa. Mucocutaneous pigmentation has been present from the age of five, with a negative family history. In our patient, esophageal endoscopy was normal, while the endoscopy of stomach and duodenum revealed multiple diminutive polyps. After clinical evaluation, there were no indications for therapy. Further follow up was suggested. Continuous surveillance is very important for patients with Peutz-Jegher’s syndrome in order to reduce risks of cancer and prevent other morbidity and mortality.

Peutz-Jegher’s Syndrome – A Case Report / Peutz-Jegher’s sindrom - prikaz slučaja

Pediatric Dermatology Unit, Clinic of Dermatovenereology, Clinical Center of Serbia, Belgrade, Serbia

Faculty of Medicine, University of Belgrade, Serbia

University Children’s Hospital, Belgrade, Serbia

Serbian Journal of Dermatology and Venereology

Peutz-Jegher’s syndrome is a hereditary disorder characterized by melanocytic macules on the lips and buccal mucosa and multiple gastrointestinal hamartomatous...

Peutz-Jegher’s Syndrome – A Case Report / Peutz-Jegher’s sindrom - prikaz slučaja

Publié en ligne: 12 févr. 2013

Pages: 77 - 80

DOI: https://doi.org/10.2478/v10249-012-0006-7

Mots clés
Peutz-Jegher’s Syndrome, Intestinal Polyposis, Child, Hyperpigmentation, Endoscopy, Gastrointestinal, Follow-Up Studies

This content is open access.

Peutz-Jegher’s Syndrome – A Case Report / Peutz-Jegher’s sindrom - prikaz slučaja

Publié en ligne: 12 févr. 2013

Pages: 77 - 80

DOI: https://doi.org/10.2478/v10249-012-0006-7

Mots clésPeutz-Jegher’s Syndrome, Intestinal Polyposis, Child, Hyperpigmentation, Endoscopy, Gastrointestinal, Follow-Up Studies

This content is open access.

Mots clés
Peutz-Jegher’s Syndrome, Intestinal Polyposis, Child, Hyperpigmentation, Endoscopy, Gastrointestinal, Follow-Up Studies