<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>The aging process is a variable, stochastic and pleiotropic phenomenon which is regulated by different environmental and genetic factors. The age-associated changes, which occur at the molecular and cellular levels and disturb biological homeostasis, may directly or indirectly contribute to aging, causing apoptosis or cellular senescence and consequently leading to the death of the organism. In this context, it is particularly interesting to observe changes in somatic cell chromatin. In the present paper, we summarized the knowledge on the biological aspects of aging with special consideration of age-related changes in chromatin like DNA damage, shortening telomeres or age-related changes in methylation of DNA.</p></abstract>

The aging process is a variable, stochastic and pleiotropic phenomenon which is regulated by different environmental and genetic factors. The age-associated changes, which occur at the molecular and cellular levels and disturb biological homeostasis, may directly or indirectly contribute to aging, causing apoptosis or cellular senescence and consequently leading to the death of the organism. In this context, it is particularly interesting to observe changes in somatic cell chromatin. In the present paper, we summarized the knowledge on the biological aspects of aging with special consideration of age-related changes in chromatin like DNA damage, shortening telomeres or age-related changes in methylation of DNA.

Aging Process in Chromatin of Animals

Department of Genetics, University of Rzeszow, Rejtana 16C, 35-959 Rzeszów, Poland

Centre of Applied Biotechnology and Basic Sciences, University of Rzeszow, Sokołowska 26, 36-100 Kolbuszowa, Poland

Laboratory of Genomics, National Research Institute of Animal Production, 32-083 Balice n. Kraków, Poland

Department of Biochemistry and Cell Biology, University of Rzeszow, Rejtana 16C, 35-959 Rzeszów, Poland

Annals of Animal Science

{"article-title":"Aging Process in Chromatin of Animals"}

The aging process is a variable, stochastic and pleiotropic phenomenon which is regulated by different environmental and genetic factors. The age-associated...

Aging Process in Chromatin of Animals

Publié en ligne: 24 juil. 2012

Pages: 301 - 309

DOI: https://doi.org/10.2478/v10220-012-0025-3

Mots clés
aging, heterochromatin, telomeres, DNA damage, rDNA

This content is open access.

Aging Process in Chromatin of Animals

Publié en ligne: 24 juil. 2012

Pages: 301 - 309

DOI: https://doi.org/10.2478/v10220-012-0025-3

Mots clésaging, heterochromatin, telomeres, DNA damage, rDNA

This content is open access.

Mots clés
aging, heterochromatin, telomeres, DNA damage, rDNA